{"id":1263,"date":"2018-04-25T13:49:10","date_gmt":"2018-04-25T13:49:10","guid":{"rendered":"https:\/\/blogs.imperial.ac.uk\/ighi\/?p=1263"},"modified":"2019-03-28T16:26:21","modified_gmt":"2019-03-28T16:26:21","slug":"malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks","status":"publish","type":"post","link":"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/","title":{"rendered":"Malaria research: Scientist industry urged to not underestimate CRISPR\u2019s risks"},"content":{"rendered":"<p><strong><em>By IGHI guest blogger\u00a0<span class=\"s1\">Chanice Henry,\u00a0<\/span><span class=\"s1\">Editor,\u00a0<\/span><span class=\"s1\"><a href=\"https:\/\/www.pharma-iq.com\/\">Pharma IQ<\/a> &amp; Pharma Logistics IQ<\/span><\/em><\/strong><\/p>\n<p><strong>Similar to new <\/strong><a href=\"https:\/\/www.theverge.com\/2018\/4\/18\/17248402\/rampage-crispr-gene-editing-technology-hollywood-science-representation\"><strong>Hollywood feature Rampage<\/strong><\/a><strong>, a recent study has urged the life sciences industry not to underestimate the dangers that could hide within CRISPR Cas9. <\/strong><\/p>\n<p>Although the film has been criticised for wildly exaggerating the capabilities of the gene editing technique, it can be recognised for its effort to draw focus from the excitable buzz around CRISPR Cas9 towards the importance of considering the ethics and dangers associated with the tool.<\/p>\n<p>A <a href=\"http:\/\/gh.bmj.com\/content\/2\/3\/e000396\">recent commentary<\/a> piece also emphasised the importance of methodically debating the potential outcomes of CRISPR within the task of tackling Malaria.<\/p>\n<p>Malaria is spread by the bite of female mosquitos holding the Plasmodium parasite. Plasmodium falciparum causes life threatening malaria.<\/p>\n<p><strong>Advances made so far <\/strong><\/p>\n<p><img decoding=\"async\" class=\"wp-image-1264 alignleft\" src=\"https:\/\/blogs.imperial.ac.uk\/ighi\/files\/2018\/04\/mosquito-19487_1920-300x225.jpg\" alt=\"\" \/>In the five years to 2015, 17 countries managed to eradicate malaria \u2013including the likes of Senegal and Bolivia. In this period, mortality fell by 50% and incidences fell by 15% \u2013 preventing over 6 million deaths.<\/p>\n<p>The World Health Organisation (<a href=\"http:\/\/www.who.int\/malaria\/media\/malaria-vaccine-implementation-qa\/en\/\">WHO) recently launched \u201cthe world\u2019s first malaria vaccine<\/a> that has been shown to provide partial protection against malaria in young children.\u201d\u00a0 After establishing efficacy in Phase 3 clinical trials a vaccine implementation programme is due to commence within this year\u2019s immunization projects in Ghana, Kenya and Malawi.<\/p>\n<p><strong>A long way to go <\/strong><\/p>\n<p>Government spend on malaria prevention has seen a dramatic increase over the past decade. Although, experts note that around $6.5 billion of funding by 2020 will be key to hitting the WHO\u2019s 2030 goal to wipe out malaria in 35 countries and shrink incidents and deaths by 90%.<\/p>\n<p><a href=\"https:\/\/www.axios.com\/back-on-the-rise-malaria-rates-call-for-global-spending-surge-73fc1577-19ba-4630-9ca0-8ba5dea96002.html\">Statistics<\/a> claim that malaria still kills one child every two minutes.<\/p>\n<p>Sub-Saharan Africa, as noted by Tanvi Nagpal, housed around 80% of the <a href=\"https:\/\/www.axios.com\/back-on-the-rise-malaria-rates-call-for-global-spending-surge-73fc1577-19ba-4630-9ca0-8ba5dea96002.html\">world\u2019s malaria cases<\/a> in 2016. \u201cTheir high infection rates are compounded by insufficient domestic budgets and struggling health systems.\u201d<a href=\"https:\/\/medicalxpress.com\/news\/2018-04-high-malaria-transmission-blood-transfusions.html\">Reports recently emerged<\/a> stating of one in four blood banks in certain areas of Sub-Saharan Africa host supplies infected with malaria causing parasites.<\/p>\n<p><a href=\"https:\/\/www.pharma-iq.com\/pre-clinical-discovery-and-development\/articles\/gene-editing-and-predictive-diagnostics\"><strong>CRISPR Cas9 <\/strong><\/a><strong>\u00a0<\/strong><\/p>\n<p>Researchers are now turning to CRISPR Cas9 to stop the disease at the source of transmission \u2013 the mosquito<strong>. <\/strong><\/p>\n<p><strong>What is CRISPR?<\/strong><\/p>\n<p>The genome-editing system based on CRISPR-Cas9 is becoming a valuable tool for different applications in biomedical research, drug discovery and human gene therapy by gene repair and gene disruption, gene disruption of viral sequences and programmable RNA targeting. \u00a0The tool permanently manipulates gene expression by using programmable DNA nuclease and can remove faulty genes from a DNA sequence.<!--more--><\/p>\n<p>Human Genetics Scientist, Joyce El Hokayem notes that in comparison to other gene editing techniques like TALENS and zinc finger nucleases or gene transfer approaches, not only is <a href=\"https:\/\/www.pharma-iq.com\/pre-clinical-discovery-and-development\/white-papers\/academic-insight-on-the-cutting-edge-of-crispr\">CRISPR Cas9<\/a> cheaper but\u00a0also much simpler to design because the process only requires making a short RNA sequence.<\/p>\n<p>These are just some of the benefits exciting the industry. It provides discovery labs with a path to quicker generations of diseases for target identification and autologous cell therapies. Mosquitoes could, theoretically, be engineered to not transmit diseases like malaria and dengue fever. Scientists could even dampen the mosquitoes\u2019 female fertility gene.<\/p>\n<p><strong>Ethical considerations &amp; Dangers <\/strong><\/p>\n<p>However, the application of CRISPR may take decades to perfect to prevent detrimental and unpredicted consequences to individuals, ecosystems and society as a whole.<\/p>\n<p>In their commentary piece Maria Patr\u00e3o Neves of the University of the Azores and Christiane Druml &#8211; a UNESCO Chair on Bioethics of the Medical University of Vienna, asks could any harmful effects be caused to <a href=\"http:\/\/gh.bmj.com\/content\/2\/3\/e000396\">humans bitten by an edited mosquito<\/a>? Also, do humans have an inherent right to edit other biological species?<\/p>\n<p>There are a few obvious areas for improvement with CRISPR\u2013 precision and efficiency being two key aspects.<\/p>\n<p>In regards to the efficiency needed for a therapeutic context, Dr Andrew Bassett Postdoctoral Fellow\u00a0Genome Engineering Oxford said that development is needed. \u201cJust, for example, the off target effects. If you\u2019re targeting in a dish with a few million cells, it\u2019s not so dramatic. But if you\u2019re targeting in the whole of the human body\u2026you need to have an incredibly low off target rate in order for that to be relevant.\u201d<\/p>\n<p>Recently specialists have been deploying innovative\u00a0<a href=\"http:\/\/www.pharma-iq.com\/business-development\/articles\/top-10-disruptive-technologies-in-pharma\/\">technologies<\/a>, such as predictive software to guide RNAs, that allow scientists to overcome these drawbacks.<\/p>\n<p>In any case, the study\u2019s authors maintained the genome techniques should only be applied in a therapeutic context when side effects are adequately known with the support of working groups and guidelines.<\/p>\n<p>\u201cThe decision to use <a href=\"http:\/\/www.pharma-iq.com\/pre-clinical-discovery-and-development\/articles\/cutting-edge-crispr-cas9-applications\">CRISPR\/Cas9<\/a> to fight malaria, or genome editing in general, does not belong solely to science, but also\u00a0requires public engagement, especially from the African communities living in malaria-endemic areas. These communities suffer from chronic poverty and\u00a0are particularly vulnerable to foreign economic interests, and having\u00a0low levels of education, they lack the\u00a0capacity for informed debate and free decision-making.\u201d<\/p>\n<p>Despite these challenges, considering the permanent moderations CRISPR Cas9 can make to life itself the communities being impacted first should be given an influential say in this debate.<\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=bycBuaC1C8s\">https:\/\/www.youtube.com\/watch?v=bycBuaC1C8s<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>By IGHI guest blogger\u00a0Chanice Henry,\u00a0Editor,\u00a0Pharma IQ &amp; Pharma Logistics IQ Similar to new Hollywood feature Rampage, a recent study has urged the life sciences industry not to underestimate the dangers that could hide within CRISPR Cas9. Although the film has been criticised for wildly exaggerating the capabilities of the gene editing technique, it can be [&hellip;]<\/p>\n","protected":false},"author":283,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14884,301308],"tags":[],"class_list":["post-1263","post","type-post","status-publish","format-standard","hentry","category-africa","category-diseases"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Malaria research: Scientist industry urged to not underestimate CRISPR\u2019s risks - Institute of Global Health Innovation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Malaria research: Scientist industry urged to not underestimate CRISPR\u2019s risks - Institute of Global Health Innovation\" \/>\n<meta property=\"og:description\" content=\"By IGHI guest blogger\u00a0Chanice Henry,\u00a0Editor,\u00a0Pharma IQ &amp; Pharma Logistics IQ Similar to new Hollywood feature Rampage, a recent study has urged the life sciences industry not to underestimate the dangers that could hide within CRISPR Cas9. Although the film has been criticised for wildly exaggerating the capabilities of the gene editing technique, it can be [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute of Global Health Innovation\" \/>\n<meta property=\"article:published_time\" content=\"2018-04-25T13:49:10+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-03-28T16:26:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.imperial.ac.uk\/ighi\/files\/2018\/04\/mosquito-19487_1920-300x225.jpg\" \/>\n<meta name=\"author\" content=\"Jo Seed\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Imperial_IGHI\" \/>\n<meta name=\"twitter:site\" content=\"@Imperial_IGHI\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jo Seed\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/\"},\"author\":{\"name\":\"Jo Seed\",\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/#\/schema\/person\/96e525d803a4519a89a8689ce380dcf4\"},\"headline\":\"Malaria research: Scientist industry urged to not underestimate CRISPR\u2019s risks\",\"datePublished\":\"2018-04-25T13:49:10+00:00\",\"dateModified\":\"2019-03-28T16:26:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/\"},\"wordCount\":848,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/#organization\"},\"image\":{\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/files\/2018\/04\/mosquito-19487_1920-300x225.jpg\",\"articleSection\":[\"African research\",\"Disease\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/\",\"url\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/\",\"name\":\"Malaria research: Scientist industry urged to not underestimate CRISPR\u2019s risks - Institute of Global Health Innovation\",\"isPartOf\":{\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/files\/2018\/04\/mosquito-19487_1920-300x225.jpg\",\"datePublished\":\"2018-04-25T13:49:10+00:00\",\"dateModified\":\"2019-03-28T16:26:21+00:00\",\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/#primaryimage\",\"url\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/files\/2018\/04\/mosquito-19487_1920-300x225.jpg\",\"contentUrl\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/files\/2018\/04\/mosquito-19487_1920-300x225.jpg\"},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/#website\",\"url\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/\",\"name\":\"Institute of Global Health Innovation\",\"description\":\"News and views on global health from staff and students within IGHI and the wider Imperial College London community.\",\"publisher\":{\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/#organization\",\"name\":\"Institute of Global Health Innovation\",\"url\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/files\/2020\/11\/Imperial_IGHI_Text-Lock-up_Blue-3.png\",\"contentUrl\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/files\/2020\/11\/Imperial_IGHI_Text-Lock-up_Blue-3.png\",\"width\":724,\"height\":426,\"caption\":\"Institute of Global Health Innovation\"},\"image\":{\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/x.com\/Imperial_IGHI\",\"https:\/\/www.instagram.com\/imperialighi\/\",\"https:\/\/www.linkedin.com\/company\/institute-of-global-health-innovation\/\",\"https:\/\/www.youtube.com\/channel\/UC3xahUn8bULYTPEbJS4L4_w\",\"https:\/\/en.wikipedia.org\/wiki\/Institute_of_Global_Health_Innovation\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/#\/schema\/person\/96e525d803a4519a89a8689ce380dcf4\",\"name\":\"Jo Seed\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/secure.gravatar.com\/avatar\/121b74bae4cc0bc5092e665f2fa3da2bd0fe47f9c8a0dc5be946102e01ec58bd?s=96&d=mm&r=g\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/121b74bae4cc0bc5092e665f2fa3da2bd0fe47f9c8a0dc5be946102e01ec58bd?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/121b74bae4cc0bc5092e665f2fa3da2bd0fe47f9c8a0dc5be946102e01ec58bd?s=96&d=mm&r=g\",\"caption\":\"Jo Seed\"},\"url\":\"https:\/\/blogs.imperial.ac.uk\/ighi\/author\/jseed\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Malaria research: Scientist industry urged to not underestimate CRISPR\u2019s risks - Institute of Global Health Innovation","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/","og_locale":"en_GB","og_type":"article","og_title":"Malaria research: Scientist industry urged to not underestimate CRISPR\u2019s risks - Institute of Global Health Innovation","og_description":"By IGHI guest blogger\u00a0Chanice Henry,\u00a0Editor,\u00a0Pharma IQ &amp; Pharma Logistics IQ Similar to new Hollywood feature Rampage, a recent study has urged the life sciences industry not to underestimate the dangers that could hide within CRISPR Cas9. Although the film has been criticised for wildly exaggerating the capabilities of the gene editing technique, it can be [&hellip;]","og_url":"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/","og_site_name":"Institute of Global Health Innovation","article_published_time":"2018-04-25T13:49:10+00:00","article_modified_time":"2019-03-28T16:26:21+00:00","og_image":[{"url":"https:\/\/blogs.imperial.ac.uk\/ighi\/files\/2018\/04\/mosquito-19487_1920-300x225.jpg","type":"","width":"","height":""}],"author":"Jo Seed","twitter_card":"summary_large_image","twitter_creator":"@Imperial_IGHI","twitter_site":"@Imperial_IGHI","twitter_misc":{"Written by":"Jo Seed","Estimated reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/#article","isPartOf":{"@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/"},"author":{"name":"Jo Seed","@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/#\/schema\/person\/96e525d803a4519a89a8689ce380dcf4"},"headline":"Malaria research: Scientist industry urged to not underestimate CRISPR\u2019s risks","datePublished":"2018-04-25T13:49:10+00:00","dateModified":"2019-03-28T16:26:21+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/"},"wordCount":848,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/#organization"},"image":{"@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/#primaryimage"},"thumbnailUrl":"https:\/\/blogs.imperial.ac.uk\/ighi\/files\/2018\/04\/mosquito-19487_1920-300x225.jpg","articleSection":["African research","Disease"],"inLanguage":"en-GB","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/","url":"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/","name":"Malaria research: Scientist industry urged to not underestimate CRISPR\u2019s risks - Institute of Global Health Innovation","isPartOf":{"@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/#website"},"primaryImageOfPage":{"@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/#primaryimage"},"image":{"@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/#primaryimage"},"thumbnailUrl":"https:\/\/blogs.imperial.ac.uk\/ighi\/files\/2018\/04\/mosquito-19487_1920-300x225.jpg","datePublished":"2018-04-25T13:49:10+00:00","dateModified":"2019-03-28T16:26:21+00:00","inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/2018\/04\/25\/malaria-research-scientist-industry-urged-to-not-underestimate-crisprs-risks\/#primaryimage","url":"https:\/\/blogs.imperial.ac.uk\/ighi\/files\/2018\/04\/mosquito-19487_1920-300x225.jpg","contentUrl":"https:\/\/blogs.imperial.ac.uk\/ighi\/files\/2018\/04\/mosquito-19487_1920-300x225.jpg"},{"@type":"WebSite","@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/#website","url":"https:\/\/blogs.imperial.ac.uk\/ighi\/","name":"Institute of Global Health Innovation","description":"News and views on global health from staff and students within IGHI and the wider Imperial College London community.","publisher":{"@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.imperial.ac.uk\/ighi\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/#organization","name":"Institute of Global Health Innovation","url":"https:\/\/blogs.imperial.ac.uk\/ighi\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.imperial.ac.uk\/ighi\/files\/2020\/11\/Imperial_IGHI_Text-Lock-up_Blue-3.png","contentUrl":"https:\/\/blogs.imperial.ac.uk\/ighi\/files\/2020\/11\/Imperial_IGHI_Text-Lock-up_Blue-3.png","width":724,"height":426,"caption":"Institute of Global Health Innovation"},"image":{"@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/Imperial_IGHI","https:\/\/www.instagram.com\/imperialighi\/","https:\/\/www.linkedin.com\/company\/institute-of-global-health-innovation\/","https:\/\/www.youtube.com\/channel\/UC3xahUn8bULYTPEbJS4L4_w","https:\/\/en.wikipedia.org\/wiki\/Institute_of_Global_Health_Innovation"]},{"@type":"Person","@id":"https:\/\/blogs.imperial.ac.uk\/ighi\/#\/schema\/person\/96e525d803a4519a89a8689ce380dcf4","name":"Jo Seed","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/121b74bae4cc0bc5092e665f2fa3da2bd0fe47f9c8a0dc5be946102e01ec58bd?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/121b74bae4cc0bc5092e665f2fa3da2bd0fe47f9c8a0dc5be946102e01ec58bd?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/121b74bae4cc0bc5092e665f2fa3da2bd0fe47f9c8a0dc5be946102e01ec58bd?s=96&d=mm&r=g","caption":"Jo Seed"},"url":"https:\/\/blogs.imperial.ac.uk\/ighi\/author\/jseed\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.imperial.ac.uk\/ighi\/wp-json\/wp\/v2\/posts\/1263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.imperial.ac.uk\/ighi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.imperial.ac.uk\/ighi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.imperial.ac.uk\/ighi\/wp-json\/wp\/v2\/users\/283"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.imperial.ac.uk\/ighi\/wp-json\/wp\/v2\/comments?post=1263"}],"version-history":[{"count":4,"href":"https:\/\/blogs.imperial.ac.uk\/ighi\/wp-json\/wp\/v2\/posts\/1263\/revisions"}],"predecessor-version":[{"id":1268,"href":"https:\/\/blogs.imperial.ac.uk\/ighi\/wp-json\/wp\/v2\/posts\/1263\/revisions\/1268"}],"wp:attachment":[{"href":"https:\/\/blogs.imperial.ac.uk\/ighi\/wp-json\/wp\/v2\/media?parent=1263"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.imperial.ac.uk\/ighi\/wp-json\/wp\/v2\/categories?post=1263"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.imperial.ac.uk\/ighi\/wp-json\/wp\/v2\/tags?post=1263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}