Search Results for: heart disease

Clement Price Thomas and a once-in-a-lifetime operation

Westminster Medical School – one of the schools that formed Imperial College School of Medicine – has been home to many pioneers. But few can claim a connection to royalty.

Sir Clement Price Thomas, student and surgeon at Westminster and one of the fathers of thoracic surgery, rose to fame after an operation on King George VI. Read on to learn just how challenging this procedure would have been.


The reign of George VI was a turbulent time for the monarchy. At the end of a brutal world war and the dissolution of the largest empire the world has ever seen, the King’s health took a turn for the worse.

Because of the King’s chest problems, Sir John Weir, the Royal Family’s doctor, called in a lung disease expert, Geoffrey Marshall, and chest expert, Sir Robert Arthur Young. After X-rays and a bronchoscopy revealed a malignant tumour in his left lung, the King’s physicians set to work organising a secret operation. They all agreed that Clement Price Thomas was the best surgeon for the job.

Setting up the makeshift theatre

The operation was planned for 22 September 1951 at Buckingham Palace. But the Buhl room clearly wasn’t designed for major surgery, despite the equipment brought in for the occasion. With the stakes so high, Price Thomas demanded that the palace install emergency lighting in the room. The palace agreed – and even moved the changing of the guard to St James’s Palace to make sure the surgical team were not disturbed by the noise outside.

On Sunday 23 September 1951, the room was ready and Price Thomas, his two surgical registrars and his scrub team set to work. (more…)

COVID-19 vaccine diaries: part two, safety first

Justine is a participant in Imperial’s COVID-19 vaccine clinical trial – here she discusses how the trial is progressing. 


“Am I immune?” “Could I be immune?”

These are questions that have been unavoidably circling in my head ever since I received an experimental coronavirus vaccine as part of a clinical trial led by Imperial College London. 

Every time I exercise, take public transport, do my weekly food shop, socialise with those close to me, I’ve been trying to quash this invisible shield that part of my brain believes might be there, shrugging off any potential encounters with the SARS-CoV-2 virus. 

I didn’t enter this trial so that I’d get a free pass to behave irresponsibly in the midst of a pandemic, which is frighteningly rearing its ugly head again in my home country. I always knew that immunity was never a certainty, having never been tested in human beings before. I was more confident that it wasn’t a dangerous thing for me to do, and certain that it was a good thing to do. 

And by participating, I have certainly helped to prove both of these latter points. I’ve had two shots of the vaccine, which works by instructing my cells to make fragments of the coronavirus, thereby prompting my immune system to react and, hopefully, keep a protective memory of the threat. I’ve had no side effects at all; not even a sore arm. The devil on my shoulder sort of wished for even a little redness where the needle went in, that I could wear proudly as a mark of my contribution to research.  (more…)

What is environmental inequality and why should we care?

Charlotte Roscoe highlights the problem of environmental inequality and explores how potential solutions such as urban green spaces may help to close the gap.


Whether it’s standing on picket lines with Mind the Pay Gap signs, whether it’s the rallying cry of Black Lives Matter, or surging child poverty across the UK: one thing inequality probably doesn’t mean to you, is city planning. Yet over 80% of the UK population live in urban areas, and the built environment is unequally impacting our health and wellbeing.

Not all urban neighbourhoods were built equal

Urban neighbourhoods designed in the past few decades of vehicle priority tend to be the most damaging to health. Car parks and roads have swallowed up our public spaces, and despite government strategies to reduce vehicle emissions via charging schemes, vehicles continue to dominate our streets.

Perhaps you’ve read headlines such as: “Traffic noise revealed as new urban killer”, or, “Each car in London costs NHS and society £8,000 due to air pollution”. These shocking news stories feature robust scientific evidence from the MRC Centre for Environment and Health, that both traffic noise and air pollution are linked to ill health, and even death.

Newsflash – traffic is bad for us! (more…)

Under pressure: how raising awareness of a silent killer can save lives on a global scale

blood pressure screening

Professor Neil Poulter puts blood pressure screening in the spotlight – an effective way of reducing the burden of high blood pressure in the UK and globally.


Blood pressure screening can save lives, which may come as a surprise considering it is such a simple measurement. Blood Pressure UK was set up as a charity aimed at lowering the nation’s blood pressure (UK), with the purpose of preventing or at least reducing disability and death associated with raised blood pressure (BP).  Among their activities, they have been running a ‘Know Your Numbers’ week every year since 2007, and their thirteenth consecutive campaign week is currently underway. ‘Pressure stations’ have been set up around the UK providing free BP screening, encouraging adults across the country to know their blood pressure numbers. (more…)

Is mycoprotein an ideal food for managing blood sugar levels in Type 2 Diabetes?

For Diabetes Awareness Week, Anna Cherta-Murillo explains how mycoprotein, a food made of fungus, may hold the promise for managing blood sugar levels in Type 2 Diabetes.


If I were to ask you the first thing that comes to mind when you think of fungi, you would probably say mouldy walls, gone-off food, or athlete’s foot. The Fungi kingdom is often not viewed in a positive light. However, we owe a lot to fungi; they produce life-saving antibiotics, have allowed organ transplantations in humans and can recycle many types of waste. In the area of nutrition, some fungi also have the potential to affect human health in a beneficial way, although little research has been devoted to it compared to other foods. In the Nutrition Section of the Department of Medicine at Imperial, we are putting fungi into the limelight and studying the impact of a particular type of fungus on blood sugar levels and appetite in South Asian and European people with Type 2 Diabetes (T2D).

The problem

1 out of 20 people worldwide has T2D, with South Asians being more prone to the disease compared to Europeans (Figure 1). People with T2D have higher blood sugar levels than normal, which over time can increase the chances of developing long-term complications such as blindness, kidney disease and heart failure. It is therefore important to manage blood sugar levels in people with T2D in order to keep blood sugar in the normal range. The first-line strategy to achieve this is by improving dietary intake. Healthy, balanced diets are generally characterised as being high in dietary fibre and protein, which decrease both blood sugar levels and appetite. If blood sugar levels are reduced toward normal levels, the chances of having T2D-related complications are reduced. Likewise, if appetite is decreased, intake of energy-rich foods will likely also decrease, helping to reduce body weight, which is a key risk factor for T2D. However, an ongoing problem with healthy diets is that they are not suitable for all cultures and most of the research around them has been conducted in people of European origin, therefore not being applicable to South Asians. Furthermore, people often find it difficult to stick to these diets. (more…)

Life as a postdoc: why I personally couldn’t imagine doing anything else

Dr Elaine Fuertes provides an insight into the perks of being a postdoc, from international travel to independently developing research with potentially important public health impacts.


“Only a tiny proportion of you will become university professors” – a statistic every postdoctoral researcher has heard, and the vast majority of us choose to ignore. Indeed, despite the increasing awareness and acknowledgement that the large majority of postdocs will end up pursuing one of the many other available career paths open to this highly trained and ambitious workforce, as recently discussed during the 2019 National Heart and Lung Institute Postdoc Day, many of us cling on to what we know to be a highly implausible outcome – landing a tenured position.

I’ve often been asked – why do I do it? Why continue down this career path, one that many of my friends and family see as living in a perpetual state of “student life”. It is indeed a question I have often reflected upon, especially as I am not presently, nor have I ever been, a “die-hard must become a Professor” type of person. So why persevere? What drives me? Why do I continue to be fully inspired and motivated by a career path that entails so much uncertainty? (more…)

A teaspoon of salt away from high blood pressure

This Salt Awareness Week, Dr Queenie Chan puts the salt intake guidelines to the test and looks at the reality of curbing salt intake for better heart health. 


Salt and sodium are often used interchangeably, but they’re not exactly the same thing. Sodium is a mineral that occurs naturally in foods or is added during manufacturing or both. Table salt is a combination of sodium and chloride, which was one of the most valuable modes of currency in ancient times. It has been used to preserve food for thousands of years and it is most commonly associated as a form of food seasoning. Salt also plays a role in food processing, providing texture and enhancing colour. (more…)

I don’t care about YOU: why sharing your electronic healthcare records with researchers shouldn’t be scary

medical records

As healthcare becomes high-tech with electronic healthcare records widely used, Eleanor Axson provides an insight into the power of medical record data for researchers. 


When I was little, going to my GP meant seeing a manila file being pulled out from a mass of identical looking files and watching her write down my measurements and test results. The file grew as I did, each year adding to my entire medical history. All in one manila folder.

Things have changed. There is no longer a manila folder growing steadily right alongside me; rather, I watch my GP click and type all my medical history into a computer. Electronic healthcare records (EHR) have irreversibly changed our doctor-going experience and they are certainly here to stay. Your electronic healthcare record contains all the information your old paper one did. Demographics, vital statistics, diagnoses, medications, medical tests, etc. (more…)

Can we trust the tobacco industry?

Image credit: Stanford Medical School

Originally published on Dr Nick Hopkinson’s blog and reproduced here with permission, this post looks at the Tobacco Industry’s dark history of appropriation and subversion of science.


It ain’t no new thing” sang Gil Scott Heron in 1972, condemning the appropriation of black culture by white recording artists. A recent research paper published in Tobacco Control throws light on Tobacco Industry appropriation and subversion of science. Their goal, to prevent or delay measures which reduce their ability to market products that are among the leading causes of death worldwide (1). (more…)