{"id":4815,"date":"2024-08-15T12:05:24","date_gmt":"2024-08-15T11:05:24","guid":{"rendered":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/?p=4815"},"modified":"2024-08-16T11:08:33","modified_gmt":"2024-08-16T10:08:33","slug":"celebrating-regius-professor-david-holden","status":"publish","type":"post","link":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/2024\/08\/15\/celebrating-regius-professor-david-holden\/","title":{"rendered":"Celebrating Regius Professor David Holden\u2019s profound impact on microbiology at Imperial and beyond"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" width=\"1181\" height=\"660\" class=\"aligncenter size-full wp-image-4816\" src=\"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/files\/2024\/08\/David-Holden-1.png\" alt=\"\" \/><\/p>\n<p><strong>In this piece Professor Ramesh Wigneshweraraj pays tribute to Professor David Holden, who retired as Regius Professor of Infectious Disease this summer.\u00a0\u00a0<\/strong><\/p>\n<hr \/>\n<h3><b><span data-contrast=\"none\">Foreword from Professor Deborah Ashby, Dean of the Faculty of Medicine<\/span><\/b><span data-ccp-props=\"{&quot;335551550&quot;:1,&quot;335551620&quot;:1}\">\u00a0<\/span><\/h3>\n<p><span data-contrast=\"none\">I am very grateful to Ramesh for penning this wonderful tribute to Professor David Holden, who retired in May having contributed so much to his field and our university.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:1,&quot;335551620&quot;:1}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">His Regius Professorship in infectious disease was <\/span><a href=\"https:\/\/www.imperial.ac.uk\/news\/172820\/cmbi-director-appointed-regius-chair-imperial\/\"><span data-contrast=\"none\">announced on 6 June<\/span><span data-contrast=\"none\"> 2016<\/span><\/a><span data-contrast=\"none\">, when the honour was granted by Queen Elizabeth II as part of her 90th birthday celebrations. It was Imperial\u2019s second, and at the time was one of only 26 Regius Professorships to have been granted since the reign of Queen Victoria. It recognised the world-leading infection research at Imperial that David has been the epitome of.<\/span><\/p>\n<p><span data-contrast=\"none\">I congratulate David on all that he has achieved and wish him all the very best in his retirement.<\/span><\/p>\n<p><!--more--><\/p>\n<hr \/>\n<p><span data-contrast=\"none\">As I compose this valedictory message to honour Regius Professor David Holden\u2019s retirement, I am reminded of a quote by the eminent philosopher, Karl Popper, a favourite of David&#8217;s: &#8220;<\/span><i><span data-contrast=\"none\">If you can\u2019t say it simply and clearly, keep quiet, and keep working on it till you can<\/span><\/i><span data-contrast=\"none\">.&#8221; This quote perfectly captures David\u2019s scientific ethos, and the profound impact he has had on the microbiology community at Imperial and beyond.<\/span><\/p>\n<p><span data-contrast=\"auto\">David is a graduate of Durham University (BSc) and University College London (PhD). He held postdoctoral positions in Canada, the USA, and the National Institute for Medical Research (NIMR), London. In 1990 he was appointed as a Lecturer at the Royal Postgraduate Medical School (which was assimilated into Imperial in 1997), becoming a full Professor in 1995. <\/span><span data-contrast=\"auto\">In 2016, he\u202fwas appointed as the first Regius Professor of Infectious Disease in the UK. <\/span><span data-contrast=\"auto\">It is at the NIMR, as <\/span><span data-contrast=\"auto\">a postdoctoral researcher, David was the first to show that colloidal gold is a sensitive and easy way to detect proteins on membranes. Today, this discovery is the basis of many commercially available colloidal gold protein stains. However, <\/span><span data-contrast=\"auto\">David is best known for inventing a methodology called \u2018signature-tagged mutagenesis\u2019 (STM; also called barcoding) for identification of mutant bacterial cells with altered growth in mixed populations. <\/span><span data-contrast=\"auto\">STM involves the construction of mutants labelled with unique identifying DNA sequence tags (barcodes), so that the fates of large numbers of different mutants can be determined simultaneously. The STM technique provided the conceptual basis for all subsequent mutant screens in microbiology. The STM approach and its derivatives (e.g., the broadly used TnSeq technique) have proved extremely popular in genetic research over the past several decades. They have been used in studies of virtually all bacterial pathogens that are amenable to genetic analysis, many fungi, parasites and in mammalian cells, where it is frequently combined with CRISPR-mediated mutagenesis. Collectively, these studies have identified many thousands of important and interesting virulence factors for follow up research. In sum, David\u2019s original discovery revolutionised the field by proposing a simple but extremely powerful technique to identify thousands of genes, in many different species, relevant to virulence and pathogenesis. Accordingly, several patents on the STM technology have been granted. It was licensed to six pharmaceutical companies and was the foundation for the formation in 1997 of the Imperial spin-off Microscience, which today is a successful UK biotech company. <\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">David first applied STM to <\/span><i><span data-contrast=\"auto\">Salmonella <\/span><\/i><span data-contrast=\"auto\">in a mouse model of typhoid fever. This led to his discovery of a set of genes, called the SPI-2 pathogenicity island, which is required for the systemic growth of <\/span><span data-contrast=\"auto\">this pathogen<\/span><span data-contrast=\"auto\"> and encodes a secretion system that delivers virulence proteins into host cells. <\/span><span data-contrast=\"auto\">He elucidated the biochemical functions of several of these virulence proteins and described how they subvert both innate and adaptive immunity. Therefore, David\u2019s work also provided important insights into the biology of eukaryotic cells. David\u2019s discovery and analysis of the SPI-2 pathogenicity island <\/span><span data-contrast=\"auto\">stimulated many other research groups to study its function, which continues to advance our understanding of <\/span><i><span data-contrast=\"auto\">Salmonella<\/span><\/i><span data-contrast=\"auto\"> pathogenesis. <\/span><span data-contrast=\"auto\">David\u2019s work also provided important insights into how bacteria grow inside host cells, and he developed unique new methods to study the properties of individual bacterial cells within a community. This revealed that internalization of <\/span><i><span data-contrast=\"auto\">Salmonella<\/span><\/i><span data-contrast=\"auto\"> by macrophages induces the formation of antibiotic-tolerant persister cells, which could seed relapsing infections and contribute to the development of antibiotic resistance.<\/span><\/p>\n<figure id=\"attachment_4818\" aria-describedby=\"caption-attachment-4818\" style=\"width: 1181px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" width=\"1181\" height=\"660\" class=\"wp-image-4818 size-full\" src=\"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/files\/2024\/08\/Holden-Lab-1991.png\" alt=\"\" \/><figcaption id=\"caption-attachment-4818\" class=\"wp-caption-text\">Holden Lab, 1991<\/figcaption><\/figure>\n<p><span data-contrast=\"auto\">David<\/span><span data-contrast=\"auto\">\u202fis a Fellow of the Royal Society, American Academy of Microbiology, EMBO and the Academy of Medical Sciences. However, David\u2019s scientific successes and prowess <\/span><span data-contrast=\"auto\">are perhaps only second to the profound impact David continues to have \u2013 individually and collectively \u2013 on the microbiology community. In 2012, under his guidance and leadership, Imperial, in collaboration with the Medical Research Council (MRC), established the Centre for Molecular Bacteriology and Infection (CMBI). At that time, the CMBI was the only Centre in the world exclusively dedicated to the study of bacterial pathogenesis. The impact the CMBI has had on the microbiology community was perfectly encapsulated by the MRC recently, which said that \u201c<\/span><i><span data-contrast=\"auto\">the Centre has made a positive contribution to the dramatic increase in capacity in this field [\u2026] such that capacity in molecular bacteriology in UK is no longer a national issue.<\/span><\/i><span data-contrast=\"auto\">\u201d<\/span><\/p>\n<p><span data-contrast=\"auto\">David was instrumental not only for the scientific successes of the CMBI but, crucially, also for his commitment to develop and mentor an impressive number of young investigators who under his guidance and leadership have now flourished, making the CMBI, now called the Centre for Bacterial Resistance Biology (CBRB), one of the most desirable places in the world for bacteriology research and training and where David\u2019s scientific legacy continues to exist.<\/span><\/p>\n<p><span data-contrast=\"auto\">To mark his retirement, David hosted a symposium to celebrate those people of whom he is profoundly proud and fond of, namely, the many alumni from his laboratory who are now themselves eminent scientists dotted across the globe, working on broad areas of bacterial infection biology. As David retired in May 2024, Imperial is privileged that he will continue to be connected to the University in the emeritus capacity. Karl Popper also said that: \u201c<\/span><i><span data-contrast=\"auto\">The best thing that can happen to a human being is to find a problem, to fall in love with that problem, and to live trying to solve that problem, unless another problem even more lovable appears<\/span><\/i><span data-contrast=\"auto\">\u201d. This quote perhaps nicely summarises how Imperial will mark David\u2019s retirement and continue to honour his legacy by awarding a quadrennial PhD studentship in his name to train the next generation of <\/span><span data-contrast=\"auto\">scientists<\/span><span data-contrast=\"auto\"> in bacterial infection biology.<\/span><\/p>\n<p><a href=\"https:\/\/profiles.imperial.ac.uk\/s.r.wig\"><b><span data-contrast=\"none\">Professor Ramesh Wigneshweraraj<\/span><\/b><\/a><b><span data-contrast=\"auto\"> is Professor<\/span><\/b><b><span data-contrast=\"auto\"> and Head of Section<\/span><\/b><b> <\/b><b><span data-contrast=\"auto\">of Molecular Microbiology at Imperial\u2019s Department of Infectious Disease and the Faculty of Medicine Campus Director for South Kensington.<\/span><\/b><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this piece Professor Ramesh Wigneshweraraj pays tribute to Professor David Holden, who retired as Regius Professor of Infectious Disease this summer.\u00a0\u00a0 Foreword from Professor Deborah Ashby, Dean of the Faculty of Medicine\u00a0 I am very grateful to Ramesh for penning this wonderful tribute to Professor David Holden, who retired in May having contributed so [&hellip;]<\/p>\n","protected":false},"author":1841,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[296217],"tags":[],"class_list":["post-4815","post","type-post","status-publish","format-standard","hentry","category-department-of-infectious-disease"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Celebrating Regius Professor David Holden\u2019s profound impact on microbiology at Imperial and beyond - Imperial Medicine Blog<\/title>\n<meta name=\"description\" content=\"In this piece Professor Ramesh Wigneshweraraj pays tribute to Professor David Holden, who retired as Regius Professor of Infectious Disease this summer.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/2024\/08\/15\/celebrating-regius-professor-david-holden\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Celebrating Regius Professor David Holden\u2019s profound impact on microbiology at Imperial and beyond - Imperial Medicine Blog\" \/>\n<meta property=\"og:description\" content=\"In this piece Professor Ramesh Wigneshweraraj pays tribute to Professor David Holden, who retired as Regius Professor of Infectious Disease this summer.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/2024\/08\/15\/celebrating-regius-professor-david-holden\/\" \/>\n<meta property=\"og:site_name\" content=\"Imperial Medicine Blog\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-15T11:05:24+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-08-16T10:08:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/files\/2024\/08\/David-Holden-1.png\" \/>\n<meta name=\"author\" content=\"Sivaramesh Wigneshweraraj\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sivaramesh Wigneshweraraj\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/2024\\\/08\\\/15\\\/celebrating-regius-professor-david-holden\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/2024\\\/08\\\/15\\\/celebrating-regius-professor-david-holden\\\/\"},\"author\":{\"name\":\"Sivaramesh Wigneshweraraj\",\"@id\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/#\\\/schema\\\/person\\\/4cf2ee540aea7db562e7fee82fa78d11\"},\"headline\":\"Celebrating Regius Professor David Holden\u2019s profound impact on microbiology at Imperial and beyond\",\"datePublished\":\"2024-08-15T11:05:24+00:00\",\"dateModified\":\"2024-08-16T10:08:33+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/2024\\\/08\\\/15\\\/celebrating-regius-professor-david-holden\\\/\"},\"wordCount\":1128,\"image\":{\"@id\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/2024\\\/08\\\/15\\\/celebrating-regius-professor-david-holden\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/files\\\/2024\\\/08\\\/David-Holden-1.png\",\"articleSection\":[\"Department of Infectious Disease\"],\"inLanguage\":\"en-GB\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/2024\\\/08\\\/15\\\/celebrating-regius-professor-david-holden\\\/\",\"url\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/2024\\\/08\\\/15\\\/celebrating-regius-professor-david-holden\\\/\",\"name\":\"Celebrating Regius Professor David Holden\u2019s profound impact on microbiology at Imperial and beyond - Imperial Medicine Blog\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/2024\\\/08\\\/15\\\/celebrating-regius-professor-david-holden\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/2024\\\/08\\\/15\\\/celebrating-regius-professor-david-holden\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/files\\\/2024\\\/08\\\/David-Holden-1.png\",\"datePublished\":\"2024-08-15T11:05:24+00:00\",\"dateModified\":\"2024-08-16T10:08:33+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/#\\\/schema\\\/person\\\/4cf2ee540aea7db562e7fee82fa78d11\"},\"description\":\"In this piece Professor Ramesh Wigneshweraraj pays tribute to Professor David Holden, who retired as Regius Professor of Infectious Disease this summer.\",\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/2024\\\/08\\\/15\\\/celebrating-regius-professor-david-holden\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/2024\\\/08\\\/15\\\/celebrating-regius-professor-david-holden\\\/#primaryimage\",\"url\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/files\\\/2024\\\/08\\\/David-Holden-1.png\",\"contentUrl\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/files\\\/2024\\\/08\\\/David-Holden-1.png\",\"width\":1181,\"height\":660},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/#website\",\"url\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/\",\"name\":\"Imperial Medicine Blog\",\"description\":\"Stories from Imperial&#039;s Faculty of Medicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/#\\\/schema\\\/person\\\/4cf2ee540aea7db562e7fee82fa78d11\",\"name\":\"Sivaramesh Wigneshweraraj\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8eb8ec7bdc022c68c4c5c17e6d20f995371f9ab59607580fd1b345fa1c1a0852?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8eb8ec7bdc022c68c4c5c17e6d20f995371f9ab59607580fd1b345fa1c1a0852?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8eb8ec7bdc022c68c4c5c17e6d20f995371f9ab59607580fd1b345fa1c1a0852?s=96&d=mm&r=g\",\"caption\":\"Sivaramesh Wigneshweraraj\"},\"url\":\"https:\\\/\\\/blogs.imperial.ac.uk\\\/imperial-medicine\\\/author\\\/srwig\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Celebrating Regius Professor David Holden\u2019s profound impact on microbiology at Imperial and beyond - Imperial Medicine Blog","description":"In this piece Professor Ramesh Wigneshweraraj pays tribute to Professor David Holden, who retired as Regius Professor of Infectious Disease this summer.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/2024\/08\/15\/celebrating-regius-professor-david-holden\/","og_locale":"en_GB","og_type":"article","og_title":"Celebrating Regius Professor David Holden\u2019s profound impact on microbiology at Imperial and beyond - Imperial Medicine Blog","og_description":"In this piece Professor Ramesh Wigneshweraraj pays tribute to Professor David Holden, who retired as Regius Professor of Infectious Disease this summer.","og_url":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/2024\/08\/15\/celebrating-regius-professor-david-holden\/","og_site_name":"Imperial Medicine Blog","article_published_time":"2024-08-15T11:05:24+00:00","article_modified_time":"2024-08-16T10:08:33+00:00","og_image":[{"url":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/files\/2024\/08\/David-Holden-1.png","type":"","width":"","height":""}],"author":"Sivaramesh Wigneshweraraj","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Sivaramesh Wigneshweraraj","Estimated reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/2024\/08\/15\/celebrating-regius-professor-david-holden\/#article","isPartOf":{"@id":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/2024\/08\/15\/celebrating-regius-professor-david-holden\/"},"author":{"name":"Sivaramesh Wigneshweraraj","@id":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/#\/schema\/person\/4cf2ee540aea7db562e7fee82fa78d11"},"headline":"Celebrating Regius Professor David Holden\u2019s profound impact on microbiology at Imperial and beyond","datePublished":"2024-08-15T11:05:24+00:00","dateModified":"2024-08-16T10:08:33+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/2024\/08\/15\/celebrating-regius-professor-david-holden\/"},"wordCount":1128,"image":{"@id":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/2024\/08\/15\/celebrating-regius-professor-david-holden\/#primaryimage"},"thumbnailUrl":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/files\/2024\/08\/David-Holden-1.png","articleSection":["Department of Infectious Disease"],"inLanguage":"en-GB"},{"@type":"WebPage","@id":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/2024\/08\/15\/celebrating-regius-professor-david-holden\/","url":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/2024\/08\/15\/celebrating-regius-professor-david-holden\/","name":"Celebrating Regius Professor David Holden\u2019s profound impact on microbiology at Imperial and beyond - Imperial Medicine Blog","isPartOf":{"@id":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/#website"},"primaryImageOfPage":{"@id":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/2024\/08\/15\/celebrating-regius-professor-david-holden\/#primaryimage"},"image":{"@id":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/2024\/08\/15\/celebrating-regius-professor-david-holden\/#primaryimage"},"thumbnailUrl":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/files\/2024\/08\/David-Holden-1.png","datePublished":"2024-08-15T11:05:24+00:00","dateModified":"2024-08-16T10:08:33+00:00","author":{"@id":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/#\/schema\/person\/4cf2ee540aea7db562e7fee82fa78d11"},"description":"In this piece Professor Ramesh Wigneshweraraj pays tribute to Professor David Holden, who retired as Regius Professor of Infectious Disease this summer.","inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/2024\/08\/15\/celebrating-regius-professor-david-holden\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/2024\/08\/15\/celebrating-regius-professor-david-holden\/#primaryimage","url":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/files\/2024\/08\/David-Holden-1.png","contentUrl":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/files\/2024\/08\/David-Holden-1.png","width":1181,"height":660},{"@type":"WebSite","@id":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/#website","url":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/","name":"Imperial Medicine Blog","description":"Stories from Imperial&#039;s Faculty of Medicine","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Person","@id":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/#\/schema\/person\/4cf2ee540aea7db562e7fee82fa78d11","name":"Sivaramesh Wigneshweraraj","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/8eb8ec7bdc022c68c4c5c17e6d20f995371f9ab59607580fd1b345fa1c1a0852?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/8eb8ec7bdc022c68c4c5c17e6d20f995371f9ab59607580fd1b345fa1c1a0852?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/8eb8ec7bdc022c68c4c5c17e6d20f995371f9ab59607580fd1b345fa1c1a0852?s=96&d=mm&r=g","caption":"Sivaramesh Wigneshweraraj"},"url":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/author\/srwig\/"}]}},"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pg9uH0-1fF","jetpack_likes_enabled":false,"_links":{"self":[{"href":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/wp-json\/wp\/v2\/posts\/4815","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/wp-json\/wp\/v2\/users\/1841"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/wp-json\/wp\/v2\/comments?post=4815"}],"version-history":[{"count":12,"href":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/wp-json\/wp\/v2\/posts\/4815\/revisions"}],"predecessor-version":[{"id":4831,"href":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/wp-json\/wp\/v2\/posts\/4815\/revisions\/4831"}],"wp:attachment":[{"href":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/wp-json\/wp\/v2\/media?parent=4815"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/wp-json\/wp\/v2\/categories?post=4815"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.imperial.ac.uk\/imperial-medicine\/wp-json\/wp\/v2\/tags?post=4815"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}