{"id":887,"date":"2020-08-10T08:40:26","date_gmt":"2020-08-10T08:40:26","guid":{"rendered":"https:\/\/blogs.imperial.ac.uk\/imperial-people\/?p=887"},"modified":"2020-08-10T08:56:33","modified_gmt":"2020-08-10T08:56:33","slug":"hadijatou-sallah-research-assistant-department-of-infectious-disease","status":"publish","type":"post","link":"https:\/\/blogs.imperial.ac.uk\/imperial-people\/2020\/08\/10\/hadijatou-sallah-research-assistant-department-of-infectious-disease\/","title":{"rendered":"Hadijatou Sallah, Research Assistant, Department of Infectious Disease"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"512\" class=\"aligncenter size-large wp-image-888\" src=\"https:\/\/blogs.imperial.ac.uk\/imperial-people\/files\/2020\/08\/20-08-Imperial-People_Twitter_TP_5-1-1024x512.jpg\" alt=\"\" \/><\/p>\n<h2><b><span data-contrast=\"auto\">\u201cOur COVID-19 vaccine work has been an immense team effort and within six months our group has begun a first-in-human trial of a\u00a0saRNA\u00a0vaccine &#8211; a great\u00a0<\/span><\/b><b><span data-contrast=\"auto\">achievement in itself<\/span><\/b><b><span data-contrast=\"auto\">.\u201d<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">I am motivated by a desire to<\/span><span data-contrast=\"auto\"> have an impact on <\/span><span data-contrast=\"auto\">human health<\/span><span data-contrast=\"auto\">\u00a0and reduce inequalities in global health. After graduating with a degree in Biomedical Science I did an internship at Imperial, where I worked on a project that assessed the role of the placenta in maternal antibody transfer and the impact of\u00a0<\/span><span data-contrast=\"auto\">maternal pertussis\u00a0<\/span><span data-contrast=\"auto\">immunisation<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">in early-life immune responses.\u00a0<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><!--more--><\/p>\n<p><span data-contrast=\"auto\">I then moved to The Gambia to work as a Scientific Officer on the Vaccines and Immunity theme of the\u00a0<\/span><span data-contrast=\"auto\">MRC Unit The Gambia at London School of Hygiene and Tropical Medicine<\/span><span data-contrast=\"auto\">\u00a0&#8211; s<\/span><span data-contrast=\"auto\">ub-Saharan Africa has a high burden of infectious disease<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">My objective was t<\/span><span data-contrast=\"auto\">o develop as a researcher and to gain experience in vaccine clinical trials.\u00a0<\/span><span data-contrast=\"auto\">My research mainly focused on infant immunology, including how maternal antibodies and infant vaccination modulate<\/span><span data-contrast=\"auto\">\u00a0infant immune responses against infections such as pertussis; biomarkers that may suggest tuberculosis susceptibility and mechanisms behind successful mucosal vaccination with the live attenuated influenza vaccine (LAIV).\u00a0<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">I recently joined Professor Robin\u00a0<\/span><span data-contrast=\"auto\">Shattock\u2019s<\/span><span data-contrast=\"auto\">\u00a0group as a Research Assistant on the CEPI funded\u00a0<\/span><span data-contrast=\"auto\">RapidVac<\/span><span data-contrast=\"auto\">\u00a0project, which aims to develop a new rapid response vaccine platform for epidemic preparedness. Coincidentally, four months later we were\u00a0<\/span><span data-contrast=\"auto\">in the midst of<\/span><span data-contrast=\"auto\">\u00a0a full-blown pandemic. I have been fortunate to have the opportunity to contribute to clinically translatable science that may have an impact on those affected by\u00a0<\/span><span data-contrast=\"auto\">COVID-19.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">My role is to test new self-amplifying RNA (<\/span><span data-contrast=\"auto\">saRNA<\/span><span data-contrast=\"auto\">) vaccines designed to induce immune responses to viruses including rabies, Ebola, Lassa and Marburg. My work involves the production, validation and analysis of RNA and vaccine formulations, followed by the assessment of vaccine potency in cell transfection experiments and in vivo in small animal models.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">However, during the lockdown I have<\/span><span data-contrast=\"auto\">\u00a0also<\/span><span data-contrast=\"auto\">\u00a0been working to produce reagents that are critical to support our COVID-19 vaccine work needed for clinical trials<\/span><span data-contrast=\"auto\">, and<\/span><span data-contrast=\"auto\">\u00a0this work has also meant that we have been able to share our Spike protein with many different research groups.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Our COVID-19 vaccine work has been an immense team effort and within six months our group has begun a first-in-human trial of a\u00a0<\/span><span data-contrast=\"auto\">saRNA<\/span><span data-contrast=\"auto\">\u00a0vaccine<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">&#8211; a great\u00a0<\/span><span data-contrast=\"auto\">achievement in itself<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">One of the most promising features of our vaccine platform is the potential for better global vaccine equity, something that I know first-hand will be a game-changer for low and middle-income countries.<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cOur COVID-19 vaccine work has been an immense team effort and within six months our group has begun a first-in-human trial of a\u00a0saRNA\u00a0vaccine &#8211; a great\u00a0achievement in itself.\u201d\u00a0 I am motivated by a desire to have an impact on human health\u00a0and reduce inequalities in global health. After graduating with a degree in Biomedical Science I [&hellip;]<\/p>\n","protected":false},"author":1226,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[294815],"tags":[],"class_list":["post-887","post","type-post","status-publish","format-standard","hentry","category-research-staff"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hadijatou Sallah, Research Assistant, Department of Infectious Disease - Imperial people<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.imperial.ac.uk\/imperial-people\/2020\/08\/10\/hadijatou-sallah-research-assistant-department-of-infectious-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hadijatou Sallah, Research Assistant, Department of Infectious Disease - Imperial people\" \/>\n<meta property=\"og:description\" content=\"\u201cOur COVID-19 vaccine work has been an immense team effort and within six months our group has begun a first-in-human trial of a\u00a0saRNA\u00a0vaccine &#8211; a great\u00a0achievement in itself.\u201d\u00a0 I am motivated by a desire to have an impact on human health\u00a0and reduce inequalities in global health. 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