{"id":102,"date":"2020-07-09T12:12:35","date_gmt":"2020-07-09T12:12:35","guid":{"rendered":"https:\/\/blogs.imperial.ac.uk\/my-path\/?p=102"},"modified":"2020-07-09T12:12:52","modified_gmt":"2020-07-09T12:12:52","slug":"answers-to-questions-posted-after-year-5-ugi-pathology-lecture","status":"publish","type":"post","link":"https:\/\/blogs.imperial.ac.uk\/my-path\/2020\/07\/09\/answers-to-questions-posted-after-year-5-ugi-pathology-lecture\/","title":{"rendered":"Answers to Questions Posted after Year 5 UGI Pathology Lecture"},"content":{"rendered":"

what are the key distinguishing factors that determine if a histological sample is dysplastic or cancer?<\/strong>
\nInvasion through the baseman membrane into the underlying connective tissue ( in the stomach that is into the lamina propria). <\/p>\n

what causes squamous cell carcinoma? (ie you referenced it occurs more commonly in developing countries).<\/strong>
\nSmoking and\/ or alcohol are important. HPV infection also has a role. <\/p>\n

I think I missed it but what is CLO-IM?<\/strong>
\nColumnar Line Oesophagus- Intestinal Metaplasia <\/p>\n

Is there such thing as chronic oesophagitis? Or does the inflammation just progress to Barrett\u2019s over time?<\/strong>
\nThese is, for example, with chronic gastro-oesophageal reflux. This will increase the risk of metaplasia <\/p>\n

Are there any practical tests for determining cag-A status of H. pylori infections and are these tests used clinically at all?<\/strong>
\nThe tests exist but are not used in routine clinical practice <\/p>\n

How common is shock due to ulcer haemorrhage?<\/strong>
\nIt depends how sever the haemorrhage is. Most bleeding from ulcers do not produce shock. <\/p>\n

is there a genetic component? i.e. Japanese man migrating to England? (if that makes sense)<\/strong>
\nThere is, and you give a good example, but environmental factors are also important. For example, even when people move they may take their diet with them. <\/p>\n

why is there a high incidence in specifically in japan?<\/strong>
\nIt is not only Japan that has a very high incidence: South Korea and Mongolia have even higher incidences. There are environmental as well as genetic factors but it is known that chronic gastritis with intesitnal metaplasia is commoner and more severe in these areas. <\/p>\n

Can intestinal gastric cancer progress to diffuse?<\/strong>
\nI don\u2019t think so but I know nothing published about this. Mixed intestinal and diffuse cancers are not uncommon. <\/p>\n

are giardia and Whipple\u2019s disease also associated with immunosuppression?<\/strong>
\nThey are (as are almost all infections). <\/p>\n","protected":false},"excerpt":{"rendered":"

what are the key distinguishing factors that determine if a histological sample is dysplastic or cancer? Invasion through the baseman membrane into the underlying connective tissue ( in the stomach that is into the lamina propria). what causes squamous cell carcinoma? (ie you referenced it occurs more commonly in developing countries). Smoking and\/ or alcohol […]<\/p>\n","protected":false},"author":1119,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[290084,290088,247574],"tags":[],"class_list":["post-102","post","type-post","status-publish","format-standard","hentry","category-gastro-intestinal-pathology","category-undergraduate-pathology","category-year-5"],"yoast_head":"\nAnswers to Questions Posted after Year 5 UGI Pathology Lecture - My Path<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.imperial.ac.uk\/my-path\/2020\/07\/09\/answers-to-questions-posted-after-year-5-ugi-pathology-lecture\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Answers to Questions Posted after Year 5 UGI Pathology Lecture - My Path\" \/>\n<meta property=\"og:description\" content=\"what are the key distinguishing factors that determine if a histological sample is dysplastic or cancer? 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