Congratulations to members of the Department who have recently had their research findings published. Here’s our round-up of the latest publication successes.
To ensure the quality and accuracy of the information published on this blog, we source our data directly from Symplectic. Our reports are generated on a monthly basis, which means there may be a delay in publicising some publications.
| Title | Canonical journal title | Publication type | Publication date | Authors OR Authors/Contributors |
| Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study. | Open Forum Infectious Diseases | Journal Article | 2021-12 | Rawson TM, Wilson RC, Moore LSP, Macgowan AP, Lovering AM, Bayliss M, Kyriakides M, Gilchrist M, Roberts JA, Hope WW, Holmes AH |
| Coupling Machine Learning and High Throughput Multiplex Digital PCR Enables Accurate Detection of Carbapenem-Resistant Genes in Clinical Isolates | Frontiers in Molecular Biosciences | Journal Article | 23/11/2021 | Miglietta L, Moniri A, Pennisi I, Malpartida-Cardenas K, Abbas H, Hill-Cawthorne K, Bolt F, Jauneikaite E, Davies F, Holmes A, Georgiou P, Rodriguez-Manzano J. |
| Paediatric tuberculosis – new advances to close persistent gaps. | International Journal of Infectious Diseases | Journal Article | 2021-12 | Marais BJ, Verkuijl S, Casenghi M, Triasih R, Hesseling AC, Mandalakas AM, Marcy O, Seddon JA, Graham SM, Amanullah F |
| Prior upregulation of interferon pathways in the nasopharynx impacts viral shedding following live attenuated influenza vaccine challenge in children | Cell Reports Medicine | Article | 2021-12 | Costa-Martins AG, Mane K, Lindsey BB, Ogava RLT, Castro Í, Jagne YJ, Sallah HJ, Armitage EP, Jarju S, Ahadzie B, Ellis-Watson R, Tregoning JS, Bingle CD, Bogaert D, Clarke E, Ordovas-Montanes J, Jeffries D, Kampmann B, Nakaya HI, de Silva TI |
| Tuberculous meningitis in children: reducing the burden of death and disability | Pathogens | Review | 30/12/2021 | Huynh J, Abo Y-N, du Preez K, Solomons R, Dooley K, Seddon J |
| Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer. | Cancer Cell | Letter | 29/12/2021 | Fendler A, Shepherd STC, Au L, Wilkinson KA, Wu M, Schmitt AM, Tippu Z, Farag S, Rogiers A, Harvey R, Carlyle E, Edmonds K, Del Rosario L, Lingard K, Mangwende M, Holt L, Ahmod H, Korteweg J, Foley T, Barber T, Emslie-Henry A, Caulfield-Lynch N, Byrne F, Shum B, Gerard CL, Deng D, Kjaer S, Song O-R, Queval C, Kavanagh C, Wall EC, Carr EJ, Namjou S, Caidan S, Gavrielides M, MacRae JI, Kelly G, Peat K, Kelly D, Murra A, Kelly K, O’Flaherty M, Shea RL, Gardner G, Murray D, Yousaf N, Jhanji S, Van As N, Young K, Furness AJS, Pickering L, Beale R, Swanton C, Crick COVID19 consortium, Gandhi S, Gamblin S, Bauer DLV, Kassiotis G, Howell M, Nicholson E, Walker S, Wilkinson RJ, Larkin J, Turajlic S, CAPTURE consortium |
| Human MAIT cells respond to and suppress HIV-1. | eLife | Journal Article | 24/12/2021 | Phetsouphanh C, Phalora P, Hackstein C-P, Thornhill J, Munier CML, Meyerowitz J, Murray L, VanVuuren C, Goedhals D, Drexhage L, Moore R, Sattentau QJ, Mak JY, Fairlie DP, Fidler S, Kelleher AD, Frater J, Klenerman P |
| Bacterial Lymphatic Metastasis in Infection and Immunity. | Cells | Journal Article, Review | 23/12/2021 | Siggins MK, Sriskandan S |
| Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection | Nature Immunology | Article, Journal | 22/12/2021 | Dowell AC, Butler MS, Jinks E, Tut G, Lancaster T, Sylla P, Begum J, Bruton R, Pearce H, Verma K, Logan N, Tyson G, Spalkova E, Margielewska-Davies S, Taylor GS, Syrimi E, Baawuah F, Beckmann J, Okike I, Ahmad S, Garstang J, Brent AJ, Brent B, Ireland G, Aiano F, Amin-Chowdhury Z, Jones S, Borrow R, Linley E, Wright J, Azad R, Waiblinger D, Davis C, Thomson E, Palmarini M, Willett BJ, Barclay WS, Poh J, Amirthalingam G, Brown KE, Ramsay ME, Zuo J, Moss P, Ladhani S |
| Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year | Nature Medicine | Article, Early Access, Journal | 20/12/2021 | Ward JL, Harwood R, Smith C, Kenny S, Clark M, Davis P, Draper E, Hargreaves D, Ladhani S, Linney M, Luyt K, Turner S, Whittaker E, Fraser LK, Viner RM |
| Durable humoral responses after the second anti-SARS-CoV-2 vaccine dose in chronic myeloid leukaemia patients on tyrosine kinase inhibitors | British Journal of Haematology | Letter, Early Access, Journal | 19/12/2021 | Claudiani S, Apperley JF, Parker EL, Marchesin F, Katsanovskaja K, Palanicawandar R, Innes AJ, Tedder RS, McClure MO, Milojkovic D |
| Exponential growth, high prevalence of SARS-CoV-2, and vaccine effectiveness associated with the Delta variant | Science | Article, Journal | 17/12/2021 | Elliott P, Haw D, Wang H, Eales O, Walters CE, Ainslie KEC, Atchison C, Fronterre C, Diggle PJ, Page AJ, Trotter AJ, Prosolek SJ, Ashby D, Donnelly CA, Barclay W, Taylor G, Cooke G, Ward H, Darzi A, Riley S |
| Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial. | The Lancet Respiratory Medicine | Journal Article | 16/12/2021 | Fisher BA, Veenith T, Slade D, Gaskell C, Rowland M, Whitehouse T, Scriven J, Parekh D, Balasubramaniam MS, Cooke G, Morley N, Gabriel Z, Wise MP, Porter J, McShane H, Ho L-P, Newsome PN, Rowe A, Sharpe R, Thickett DR, Bion J, Gates S, Richards D, Kearns P, CATALYST investigators |
| Regulatory T Cells in acute and chronic human Chikungunya infection. | Microbes and Infection: a journal on infectious agents and host defenses | Journal Article | 16/12/2021 | Gois BM, Peixoto RF, Guerra-Gomes IC, Henrique de Sousa Palmeira P, Nóbrega de Sousa Dias C, Galvão Araújo JM, Veras RC, Medeiros IA, de Lourdes Assunção Araújo de Azevedo F, Boyton RJ, Altmann DM, Lima Keesen TS |
| BpOmpW Antigen Stimulates the Necessary Protective T-Cell Responses Against Melioidosis | Frontiers in Immunology | Article, Journal | 13/12/2021 | Tomas-Cortazar J, Bossi L, Quinn C, Reynolds CJ, Butler DK, Corcoran N, Murchu MO, McMahon E, Singh M, Rongkard P, Anguita J, Blanco A, Dunachie SJ, Altmann D, Boyton RJ, Arnold J, Giltaire S, McClean S |
| Blocking T-cell egress with FTY720 extends DNA vaccine expression but reduces immunogenicity | Immunology | Article, Early Access, Journal | 12/12/2021 | Mann JFS, McKay PF, Klein K, Pankrac J, Tregoning JS, Shattock RJ |
| SARS-CoV-2-host cell surface interactions and potential antiviral therapies | Interface Focus | Review, Journal | 10/12/2021 | Butnariu A-B, Look A, Grillo M, Tabish TA, McGarvey MJ, Pranjol MZ |
| The global burden of tuberculous meningitis in adults: a modelling study | PLOS Global Public Health | Article | 08/12/2021 | Dodd PJ, Osman M, Cresswell F, Stadelman A, Huu Lan N, Tyhy Thuong Thuong N, Muzyamba M, Glaser L, Dlamini S, Seddon J |
| The vulnerable versatility of Salmonella antibiotic persisters during infection | Cell Host and Microbe | Article, Journal | 08/12/2021 | Hill PWS, Moldoveanu AL, Sargen M, Ronneau S, Glegola-Madejska I, Beetham C, Fisher RA, Helaine S |
| Correlation between cerebrospinal fluid and plasma neurofilament light protein in treated HIV infection: results from the COBRA study | Journal of NeuroVirology | Article, Early Access, Journal | 07/12/2021 | Alagaratnam J, De Francesco D, Zetterberg H, Heslegrave A, Toombs J, Kootstra NA, Underwood J, Gisslen M, Reiss P, Fidler S, Sabin CA, Winston A |
| Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity. | Journal of Experimental Medicine | Journal Article, Research Support, Non-U.S. Gov’t | 06/12/2021 | Pyle CJ, Labeur-Iurman L, Groves HT, Puttur F, Lloyd CM, Tregoning JS, Harker JA |
| Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: a global perspective | Nature Reviews Cardiology | Review, Early Access, Journal | 06/12/2021 | Halawa S, Pullamsetti SS, Bangham CRM, Stenmark KR, Dorfmuller P, Frid MG, Butrous G, Morrell NW, de Jesus Perez VA, Stuart DI, O’Gallagher K, Shah AM, Aguib Y, Yacoub MH |
| Global surveillance, research, and collaboration needed to improve understanding and management of long COVID | The Lancet | Editorial Material, Editorial material, Journal | 04/12/2021 | Ward H, Flower B, Garcia PJ, Ong SWX, Altmann DM, Delaney B, Smith N, Elliott P, Cooke G |
| Insaka: mobile phone support groups for adolescent pregnant women living with HIV (vol 21, 663, 2021) | BMC Pregnancy and Childbirth | Correction, Journal | 02/12/2021 | Simpson N, Kydd A, Phiri M, Mbewe M, Sigande L, Gachie T, Ngobeni M, Monese T, Figerova Z, Schlesinger H, Bond V, Belemu S, Simwinga M, Schaap A, Biriotti M, Fidler S, Ayles H |
| Iron metabolism as a novel therapeutic target | Blood | Editorial Material, Editorial material, Journal | 02/12/2021 | Farrell PJ |
| A high-throughput pipeline for scalable kit-free RNA extraction | Scientific Reports | Article, Journal | 01/12/2021 | Han P, Go MK, Chow JY, Xue B, Lim YP, Crone MA, Storch M, Freemont PS, Yew WS |