Latest publications: December 2022

Congratulations to members of the Department who have recently had their research findings published. Here’s our round-up of the latest publication successes.

To ensure the quality and accuracy of the information published on this blog, we source our data directly from Symplectic. Our reports are generated on a monthly basis, which means there may be a delay in publicising some publications.

Title Canonical journal title Publication type Authors OR Authors/Contributors Publication date
A multicentre evaluation and expert recommendations of use of the newly developed BioFire Joint Infection polymerase chain reaction panel European Journal of Clinical Microbiology and Infectious Diseases Article, Early Access, Journal Saeed K, Ahmad-Saeed N, Annett R, Barlow G, Barrett L, Boyd SE, Boran N, Davies P, Hughes H, Jones G, Leach L, Lynch M, Nayar D, Maloney RJ, Marsh M, Milburn O, Mitchell S, Moffat L, Moore LSP, Murphy ME, O’Shea SA, O’Sullivan F, Peach T, Petridou C, Reidy N, Selvaratnam M, Talbot B, Taylor V, Wearmouth D, Aldridge C 07/12/2022
A phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for HIV-associated tuberculous meningitis (The LASER-TBM Trial). Clinical Infectious Diseases Journal Article Davis AG, Wasserman S, Stek C, Maxebengula M, Liang CJ, Stegmann S, Koekemoer S, Jackson A, Kadernani Y, Bremer M, Daroowala R, Aziz S, Goliath R, Sai LL, Sihoyiya T, Denti P, Lai RP, Crede T, Naude J, Szymanski P, Vallie Y, Banderker IA, Moosa MS, Raubenheimer P, Candy S, Offiah C, Wahl G, Vorster I, Maartens G, Black J, Meintjes G, Wilkinson RJ 09/12/2022
Assessment of a diverse panel of transmitted/founder HIV-1 infectious molecular clones in a luciferase based CD8 T-cell mediated viral inhibition assay Frontiers in Immunology Article, Journal Fernandez N, Hayes P, Makinde J, Hare J, King D, Xu R, Rehawi O, Mezzell AT, Kato L, Mugaba S, Serwanga J, Chemweno J, Nduati E, Price MA, Osier F, Ochsenbauer C, Yue L, Hunter E, Gilmour J, IAVI PCI 01/12/2022
Availability and use of rapid diagnostic tests for the management of acute childhood infections in Europe: A cross-sectional survey of paediatricians. PLoS One Journal Article, Research Support, Non-U.S. Gov’t Dewez JE, Pembrey L, Nijman RG, Del Torso S, Grossman Z, Hadjipanayis A, Van Esso D, Lim E, Emonts M, Burns J, Gras-LeGuen C, Kohlfuerst D, Dornbusch HJ, Brengel-Pesce K, Mallet F, von Both U, Tsolia M, Eleftheriou I, Zavadska D, de Groot R, van der Flier M, Moll H, Hagedoorn N, Borensztajn D, Oostenbrink R, Kuijpers T, Pokorn M, Vincek K, Martinón-Torres F, Rivero I, Agyeman P, Carrol ED, Paulus S, Cunnington A, Herberg J, Levin M, Mujkić A, Geitmann K, Da Dalt L, Valiulis A, Lapatto R, Syridou G, Altorjai P, Torpiano P, Størdal K, Illy K, Mazur A, Spreitzer MV, Rios J, Wyder C, Romankevych I, Basmaci R, Ibanez-Mico S, Yeung S 20/12/2022
Avian Influenza A Virus polymerase can utilise human ANP32 proteins to support cRNA but not vRNA synthesis mBio Journal Article Swann O, Rasmussen A, Peacock T, Sheppard C, Barclay W 16/01/2023
Bolaamphiphile Analogues of 12-bis-THA Cl2 Are Potent Antimicrobial Therapeutics with Distinct Mechanisms of Action against Bacterial, Mycobacterial, and Fungal Pathogens. mSphere Journal Article Di Blasio S, Clarke M, Hind CK, Asai M, Laurence L, Benvenuti A, Hassan M, Semenya D, Man DK-W, Horrocks V, Manzo G, Van Der Lith S, Lam C, Gentile E, Annette C, Bosse J, Li Y, Panaretou B, Langford PR, Robertson BD, Lam JKW, Sutton JM, McArthur M, Mason AJ 13/12/2022
Case-Finding Strategies for Drug-Resistant Tuberculosis: Protocol for a Scoping Review. JMIR Research Protocols Journal Article Van Wyk SS, Nliwasa M, Seddon JA, Hoddinott G, Viljoen L, Nepolo E, Günther G, Ruswa N, Lin H-H, Niemann S, Gandhi NR, Shah NS, Claassens M 15/12/2022
Changing patterns of clinical presentation of COVID-19 in hospital admissions: With, or because of, COVID? Journal of Infection Letter, Research Support, Non-U.S. Gov’t Rafferty H, Cann A, Daunt A, Cooke GS 01/12/2022
Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study. Lancet Infectious Diseases Journal Article Fink DL, Callaby H, Luintel A, Beynon W, Bond H, Lim EY, Gkrania-Klotsas E, Heskin J, Bracchi M, Rathish B, Milligan I, O’Hara G, Rimmer S, Peters JR, Payne L, Mody N, Hodgson B, Lewthwaite P, Lester R, Woolley SD, Sturdy A, Whittington A, Johnson L, Jacobs N, Quartey J, Ai Payne B, Crowe S, Elliott IA, Harrison T, Cole J, Beard K, Cusack T-P, Jones I, Banerjee R, Rampling T, Specialist and High Consequence Infectious Diseases Centres Network for Monkeypox, Dunning J 22/12/2022
Correlates of immunity to Group A Streptococcus – a pathway to vaccine development npj Vaccines Journal Article Frost H, Jean-Louis E, Sriskandan S, Alma F 17/12/2022
Corrigendum to “Should paediatric chest compression depth targets consider body habitus? – A chest computed tomography imaging study” [Resuscitation Plus 9 (2022) 100202]. Resuscitation Plus Review, Journal Ong GY-K, Ang AJF, Chen ZJ, Chan YH, Tang PH, Fong ESS, Tan JY, Aurangzeb ASO, Pek JH, Maconochie I, Ng KC, Nadkarni V 01/12/2022
COVID-19 vaccine boosted immunity against Omicron in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors. Leukemia Journal Article Milojkovic D, Reynolds CJ, Sandoval DM, Pieper FP, Liu S, Pade C, Gibbons JM, McKnight Á, Loaiza S, Palanicawander R, Innes AJ, Claudiani S, Apperley JF, Altmann DM, Boyton RJ 17/12/2022
Decision Criteria for Selecting Essential Medicines and their Connection to Guidelines: An Interpretive Descriptive Qualitative Interview Study. Journal of Clinical Epidemiology Journal Article Piggott T, Moja L, Akl EA, Lavis J, Cooke G, Kredo T, Hogerzeil HV, Huttner B, Alonso-Coello P, Schünemann H 27/12/2022
Development of the gut microbiota during early life in premature and term infants Gut Pathogens Journal Article Sim K, Powell E, Emma C, Kroll JS, Shaw A 16/01/2023
Estimated economic burden of genital herpes and HIV attributable to herpes simplex virus type 2 infections in 90 low- and middle-income countries: A modeling study. PLoS Medicine Systematic Review, Journal Article, Research Support, Non-U.S. Gov’t Silva S, Ayoub HH, Johnston C, Atun R, Abu-Raddad LJ 01/12/2022
Galleria mellonella as an infection model for the virulent Mycobacterium tuberculosis H37Rv Virulence Article, Journal Asai M, Li Y, Spiropoulos J, Cooley W, Everest DJ, Kendall SL, Martin C, Robertson BD, Langford PR, Newton SM 31/12/2022
Global impact of COVID-19 on childhood tuberculosis: an analysis of notification data The Lancet Global Health Article, Journal Ranasinghe L, Achar J, Groschel MI, Whittaker E, Dodd PJ, Seddon JA 01/12/2022
Haematological and hepatic adverse effects of ceftriaxone in ambulatory care: a dual-centre retrospective observational analysis of standard vs high dose. BMC Infectious Diseases Observational Study, Journal Article Mistry R, Rawson TM, Troise O, Mughal N, Moore LSP, Hughes S 24/12/2022
Hemostasis Proteins in Invasive Meningococcal and Nonmeningococcal Infections: A Prospective Multicenter Study. Pediatric Critical Care Medicine Multicenter Study, Journal Article Hagedoorn NN, Boeddha NP, Kohlfuerst DS, Anderson S, Carrol ED, Agapow P, van der Flier M, Hazelzet J, Herberg J, Kuijpers T, Levin M, Martinon-Torres F, van Rijswijk A, Schlapbach LJ, Vermont C, Zenz W, Dik WA, Driessen G, Emonts M, European Union Childhood Life-threatening Infectious Disease (EUCLIDS) Consortium 01/12/2022
Imbalance of peptidoglycan biosynthesis alters the cell surface charge of Listeria monocytogenes The Cell Surface Article Schulz LM, Rothe P, Halbedel S, Gründling A, Rismondo J 01/12/2022
Impact of Inappropriate Empirical Antibiotic on Outcomes in Community-acquired Third Generation Cephalosporin Resistant Enterobacterales Bacteremia. Infection and Chemotherapy Journal Article Nasomsong W, Changpradub D, Vasikasin V 01/12/2022
Impact of meningococcal ACWY conjugate vaccines on pharyngeal carriage in adolescents: evidence for herd protection from the UK MenACWY programme. Clinical Microbiology and Infection Observational Study, Journal Article Carr JP, MacLennan JM, Plested E, Bratcher HB, Harrison OB, Aley PK, Bray JE, Camara S, Rodrigues CMC, Davis K, Bartolf A, Baxter D, Cameron JC, Cunningham R, Faust SN, Fidler K, Gowda R, Heath PT, Hughes S, Khajuria S, Orr D, Raman M, Smith A, Turner DPJ, Whittaker E, Williams CJ, Zipitis CS, Pollard AJ, Oliver J, Morales-Aza B, Lekshmi A, Clark SA, Borrow R, Christensen H, Trotter C, Finn A, Maiden MC, Snape MD, UKMenCar4 and ‘Be on the TEAM’ Study Collaborators 01/12/2022
Learning from electronic prescribing errors: a mixed methods study of junior doctors’ perceptions of training and individualised feedback data. BMJ Open Journal Article, Research Support, Non-U.S. Gov’t Chu A, Kumar A, Depoorter G, Franklin BD, McLeod M 22/12/2022
Mechanisms of DNA opening revealed in AAA+ transcription complex structures. Science Advances Journal Article Ye F, Gao F, Liu X, Buck M, Zhang X 21/12/2022
Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study. The Lancet Gastroenterology & Hepatology Journal Article Liu Z, Le K, Zhou X, Alexander JL, Lin S, Bewshea C, Chanchlani N, Nice R, McDonald TJ, Lamb CA, Sebastian S, Kok K, Lees CW, Hart AL, Pollok RC, Boyton RJ, Altmann DM, Pollock KM, Goodhand JR, Kennedy NA, Ahmad T, Powell N, CLARITY study investigators 05/12/2022
Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis. PLoS One Journal Article, Research Support, Non-U.S. Gov’t Meier S, Seddon JA, Maasdorp E, Kleynhans L, du Plessis N, Loxton AG, Malherbe ST, Zak DE, Thompson E, Duffy FJ, Kaufmann SHE, Ottenhoff THM, Scriba TJ, Suliman S, Sutherland JS, Winter J, Kuivaniemi H, Walzl G, Tromp G, GC6-74 Consortium, Catalysis TB Biomarkers Consortium 01/12/2022
NrnA is a 5 ‘-3 ‘ exonuclease that processes short RNA substrates in vivo and in vitro Nucleic Acids Research Article, Early Access, Journal Weiss CA, Myers TM, Wu CH, Jenkins C, Sondermann H, Lee VT, Winkler WC 07/12/2022
Nystatin is commonly prescribed as prophylaxis in children beyond the neonatal age Medical Mycology Journal Article Jayawardena-Thabrew H, Warris A, Ferreras-Antolin L 29/12/2022
Placental macrophage responses to viral and bacterial ligands and the influence of fetal sex. iScience Journal Article Pantazi P, Kaforou M, Tang Z, Abrahams VM, McArdle A, Guller S, Holder B 22/12/2022
Plasmodium infection is associated with cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein. Scientific Reports Journal Article Lapidus S, Liu F, Casanovas-Massana A, Dai Y, Huck JD, Lucas C, Klein J, Filler RB, Strine MS, Sy M, Deme AB, Badiane AS, Dieye B, Ndiaye IM, Diedhiou Y, Mbaye AM, Diagne CT, Vigan-Womas I, Mbengue A, Sadio BD, Diagne MM, Moore AJ, Mangou K, Diallo F, Sene SD, Pouye MN, Faye R, Diouf B, Nery N, Costa F, Reis MG, Muenker MC, Hodson DZ, Mbarga Y, Katz BZ, Andrews JR, Campbell M, Srivathsan A, Kamath K, Baum-Jones E, Faye O, Sall AA, Vélez JCQ, Cappello M, Wilson M, Ben-Mamoun C, Tedder R, McClure M, Cherepanov P, Somé FA, Dabiré RK, Moukoko CEE, Ouédraogo JB, Boum Y, Shon J, Ndiaye D, Wisnewski A, Parikh S, Iwasaki A, Wilen CB, Ko AI, Ring AM, Bei AK 22/12/2022
POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells. Molecular Cell Journal Article Belan O, Sebald M, Adamowicz M, Anand R, Vancevska A, Neves J, Grinkevich V, Hewitt G, Segura-Bayona S, Bellelli R, Robinson HMR, Higgins GS, Smith GCM, West SC, Rueda DS, Boulton SJ 15/12/2022
Rapid reconfiguration of sexual health services in response to UK autochthonous transmission of mpox (monkeypox). Sexually Transmitted Infections Editorial Heskin J, Dickinson M, Brown N, Girometti N, Feeney M, Hardie J, Evans C, McOwan A, Higgs C, Basnayake S, Davies GW, Randell P, Bracchi M, Boffito M, Asboe D, Moore LS, Rayment M, Mughal N, Byrne R, Jones R 15/12/2022
Recurrent visceral leishmaniasis relapses in HIV co-infected patients are characterised by less efficient immune responses and higher parasite load iScience Journal Article Takele Y, Mulaw T, Adem E, Womersley R, Kaforou M, Franssen SU, Michael levin, Taylor GP, Müller I, Cotton JA, Kropf P 01/12/2022
Risk factors of poor developmental outcome in children with tuberculous meningitis. Child’s Nervous System Journal Article Saal C-L, Springer P, Seddon JA, van Toorn R, Esterhuizen TM, Solomons RS 16/12/2022
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBioMedicine Journal Article Liew F, Talwar S, Cross A, Willett BJ, Scott S, Logan N, Siggins MK, Swieboda D, Sidhu JK, Efstathiou C, Moore SC, Davis C, Mohamed N, Nunag J, King C, Thompson AAR, Rowland-Jones SL, Docherty AB, Chalmers JD, Ho L-P, Horsley A, Raman B, Poinasamy K, Marks M, Kon OM, Howard L, Wootton DG, Dunachie S, Quint JK, Evans RA, Wain LV, Fontanella S, de Silva TI, Ho A, Harrison E, Baillie JK, Semple MG, Brightling C, Thwaites RS, Turtle L, Openshaw PJM, ISARIC4C Investigators, PHOSP-COVID collaborative group 16/12/2022
Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub. eLife Journal Article Wilkinson M, Wilkinson OJ, Feyerherm C, Fletcher EE, Wigley DB, Dillingham MS 19/12/2022
Telemedicine interventions in six conflict-affected countries in the WHO Eastern Mediterranean region: a systematic review. Conflict and Health Journal Article, Review Parkes P, Pillay TD, Bdaiwi Y, Simpson R, Almoshmosh N, Murad L, Abbara A 14/12/2022
The NLRP3 inflammasome: regulation by metabolic signals. Trends in Immunology Journal Article, Review Olona A, Leishman S, Anand PK 01/12/2022
The role of public involvement in the design of the first SARS-CoV-2 human challenge study during an evolving pandemic Epidemics: the journal of infectious disease dynamics Article, Journal Piggin M, Smith E, Mankone P, Ndegwa L, Gbesemete D, Pristera P, Bahrami-Hessari M, Johnson H, Catchpole AP, Openshaw PJM, Chiu C, Read RC, Ward H, Barker C 01/12/2022
Three-dose vaccination-induced immune responses protect against SARS-CoV-2 Omicron BA.2: A population-based study in Hong Kong. The Lancet Regional Health Western Pacific Journal Article Zhou R, Liu N, Li X, Peng Q, Yiu C-K, Huang H, Yang D, Du Z, Kwok H-Y, Au K-K, Cai J-P, Fan-Ngai Hung I, Kai-Wang To K, Xu X, Yuen K-Y, Chen Z 23/12/2022
Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19. Nature Communications Journal Article, Research Support, Non-U.S. Gov’t Maher AK, Burnham KL, Jones EM, Tan MMH, Saputil RC, Baillon L, Selck C, Giang N, Argüello R, Pillay C, Thorley E, Short C-E, Quinlan R, Barclay WS, Cooper N, Taylor GP, Davenport EE, Dominguez-Villar M 26/12/2022
Understanding the biology, morbidity and social contexts of adolescent tuberculosis: a prospective observational cohort study protocol (Teen TB). BMJ Open Journal Article Swanepoel J, Zimri K, van der Zalm MM, Hoddinott G, Palmer M, Doruyter A, De Beer G, Kleynhans L, Johnson SM, Jongen V, Wademan D, Mcimeli K, Jacobs S, Swanepoel R, Van Zyl G, Allwood BW, Malherbe S, Heuvelings C, Griffith-Richards S, Whittaker E, Moore DAJ, Schaaf HS, Hesseling AC, Seddon JA 20/12/2022
Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients. Viruses Journal Article, Review Giotis ES, Cil E, Brooke GN 07/12/2022
Weaponisation of water. The Lancet Letter, Comment Abbara A, Almhawish N, Aladhan I, Alobaid R, Karah N 03/12/2022
What can be learned from the literature about intervals and strategies for paediatric CPR retraining of healthcare professionals? A scoping review of literature Rescuscitation Plus Review, Journal Gugelmin-Almeida D, Tobase L, Maconochie I, Polastri T, Gesteira ECR, Williams J 01/12/2022
Women for science and science for women: Gaps, challenges and opportunities towards optimizing pre-exposure prophylaxis for HIV-1 prevention. Frontiers in Immunology Journal Article, Review Karim QA, Archary D, Barré-Sinoussi F, Broliden K, Cabrera C, Chiodi F, Fidler SJ, Gengiah TN, Herrera C, Kharsany ABM, Liebenberg LJP, Mahomed S, Menu E, Moog C, Scarlatti G, Seddiki N, Sivro A, Cavarelli M 06/12/2022

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