Congratulations to members of the Department who have recently had their research findings published. Here’s our round-up of the latest publication successes.
To ensure the quality and accuracy of the information published on this blog, we source our data directly from Symplectic. Our reports are generated on a monthly basis, which means there may be a delay in publicising some publications.
| Title | Canonical journal title | Publication type | Authors OR Authors/Contributors | Publication date |
| A Role for the RNA Polymerase Gene Specificity Factor σ54 in the Uniform Colony Growth of Uropathogenic Escherichia coli. | Journal of Bacteriology | Journal Article | Switzer A, Burchell L, Mitsidis P, Thurston T, Wigneshweraraj S | 19/04/2022 |
| Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease. | Journal of Clinical Investigation | Journal Article | Singanayagam A, Footitt J, Marczynski M, Radicioni G, Cross MT, Finney LJ, Trujillo-Torralbo M-B, Calderazzo M, Zhu J, Aniscenko J, Clarke TB, Molyneaux PL, Bartlett NW, Moffatt MF, Cookson WO, Wedzicha J, Evans CM, Boucher RC, Kesimer M, Lieleg O, Mallia P, Johnston SL | 15/04/2022 |
| An Innovative Approach to Providing Web-Enabled Diagnostic Laboratory Services in Syria | American Journal of Clinical Pathology | Article, Journal | Karah N, Antypas K, Al-toutanji A, Suveyd U, Rafei R, Haraoui L-P, Elamin W, Hamze M, Abbara A, Rhoads DD, Pantanowitz L, Uhlin BE | 01/04/2022 |
| Bacterial toxin-triggered release of antibiotics from capsosomes protects a fly model from lethal methicillin-resistant Staphylococcus aureus (MRSA) infection. | Advanced Healthcare Materials | Journal Article | Tonkin RL, Klöckner A, Najer A, da Silva CJS, Echalier C, Dionne MS, Edwards AM, Stevens MM | 28/04/2022 |
| Baseline IL-6 is a biomarker for unfavourable tuberculosis treatment outcomes: a multisite discovery and validation study. | European Respiratory Journal | Journal Article | Gupte AN, Kumar P, Araújo-Pereira M, Kulkarni V, Paradkar M, Pradhan N, Menon P, Padmapriyadarsini C, Hanna L-E, Yogendra Shivakumar SVB, Rockwood N, Du Bruyn E, Karyakarte R, Gaikwad S, Bollinger R, Golub J, Gupte N, Viswanathan V, Wilkinson RJ, Mave V, Babu S, Kornfeld H, Andrade BB, Gupta A | 2022-04 |
| BSAC Vanguard Series: Why culture matters to tackle antibiotic resistance | Journal of Antimicrobial Chemotherapy | Article, Early Access, Journal | Charani E | 06/04/2022 |
| Cohorting inpatients with Omicron and Delta variants of Sars-CoV-2 does not increase rates of mixed infection. | Journal of Infection | Letter | Davies J, Gibani MM, Portone G, McGregor A | 12/04/2022 |
| Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves. | Pediatric Research | Journal Article | Swann OV, Pollock L, Holden KA, Munro APS, Bennett A, Williams TC, Turtle L, Fairfield CJ, Drake TM, Faust SN, Sinha IP, Roland D, Whittaker E, Ladhani SN, Nguyen-Van-Tam JS, Girvan M, Donohue C, Donegan C, Spencer RG, Hardwick HE, Openshaw PJM, Baillie JK, Harrison EM, Docherty AB, Semple MG, ISARIC4C Investigators | 22/04/2022 |
| Comparison of vaccine effectiveness against the Omicron (B.1.1.529) variant in haemodialysis patients. | Kidney International Reports | Journal Article | Spensley KJ, Gleeson S, Martin P, Thomson T, Clarke CL, Pickard G, Thomas D, McAdoo SP, Randell P, Kelleher P, Bedi R, Lightstone L, Prendecki M, Willicombe M | 13/04/2022 |
| COVID-19 Vaccine Hesitancy in Diverse Groups in the UK-Is the Driver Economic or Cultural in Student Populations | Vaccines | Article, Journal | Drobniewski F, Kusuma D, Broda A, Castro-Sanchez E, Ahmad R | 01/04/2022 |
| COVID-19 vaccine-induced antibody responses in immunosuppressed patients with inflammatory bowel disease (VIP): a multicentre, prospective, case-control study. | The Lancet Gastroenterology & Hepatology | Journal Article, Multicenter Study, Research Support, Non-U.S. Gov’t | Alexander JL, Kennedy NA, Ibraheim H, Anandabaskaran S, Saifuddin A, Castro Seoane R, Liu Z, Nice R, Bewshea C, D’Mello A, Constable L, Jones GR, Balarajah S, Fiorentino F, Sebastian S, Irving PM, Hicks LC, Williams HRT, Kent AJ, Linger R, Parkes M, Kok K, Patel KV, Teare JP, Altmann DM, Boyton RJ, Goodhand JR, Hart AL, Lees CW, Ahmad T, Powell N, VIP study investigators | 2022-04 |
| Delineating the impact of COVID-19 on antimicrobial resistance: An Indian perspective. | Science of the Total Environment | Journal Article, Review | Seethalakshmi PS, Charity OJ, Giakoumis T, Kiran GS, Sriskandan S, Voulvoulis N, Selvin J | 20/04/2022 |
| Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility | Journal of Virological Methods | Article, Journal | Rosadas C, Khan M, Parker E, Marchesin F, Katsanovskaja K, Sureda-Vives M, Fernandez N, Randell P, Harvey R, Lilley A, Harris BHL, Zuhair M, Fertleman M, Ijaz S, Dicks S, Short C-E, Quinlan R, Taylor GP, Hu K, McKay P, Rosa A, Roustan C, Zuckerman M, El Bouzidi K, Cooke G, Flower B, Moshe M, Elliott P, Spencer AJ, Lambe T, Gilbert SC, Kingston H, Baillie JK, Openshaw PJM, Semple MG, Cherepanov P, McClure MO, Tedder RS | 01/04/2022 |
| Diagnostic Challenges in Childhood Pulmonary Tuberculosis-Optimizing the Clinical Approach | Pathogens | Review, Journal | Gunasekera KS, Vonasek B, Oliwa J, Triasih R, Lancioni C, Graham SM, Seddon JA, Marais BJ | 01/04/2022 |
| Drug concentration at the site of disease in children with pulmonary tuberculosis | Journal of Antimicrobial Chemotherapy | Article, Early Access, Journal | Lopez-Varela E, Abulfathi AA, Strydom N, Goussard P, van Wyk AC, Demers AM, Van Deventer A, Garcia-Prats AJ, van der Merwe J, Zimmerman M, Carter CL, Janson J, Morrison J, Reuter H, Decloedt EH, Seddon JA, Svensson EM, Warren R, Savic RM, Dartois V, Hesseling AC | 25/04/2022 |
| Durability of ChAdOx1 nCoV-19 vaccination in people living with HIV. | JCI Insight | Clinical Trial, Phase II, Clinical Trial, Phase III, Journal Article | Ogbe A, Pace M, Bittaye M, Tipoe T, Adele S, Alagaratnam J, Aley PK, Ansari MA, Bara A, Broadhead S, Brown A, Brown H, Cappuccini F, Cinardo P, Dejnirattisai W, Ewer KJ, Fok H, Folegatti PM, Fowler J, Godfrey L, Goodman AL, Jackson B, Jenkin D, Jones M, Longet S, Makinson RA, Marchevsky NG, Mathew M, Mazzella A, Mujadidi YF, Parolini L, Petersen C, Plested E, Pollock KM, Rajeswaran T, Ramasamy MN, Rhead S, Robinson H, Robinson N, Sanders H, Serrano S, Tipton T, Waters A, Zacharopoulou P, Barnes E, Dunachie S, Goulder P, Klenerman P, Screaton GR, Winston A, Hill AV, Gilbert SC, Carroll M, Pollard AJ, Fidler S, Fox J, Lambe T, Frater J | 08/04/2022 |
| Estimating the contribution of transmission in primary healthcare clinics to community-wide TB disease incidence, and the impact of infection prevention and control interventions, in KwaZulu-Natal, South Africa | BMJ Global Health | Article, Journal | McCreesh N, Karat AS, Govender I, Baisley K, Diaconu K, Yates TA, Houben RM, Kielmann K, Grant AD, White R | 01/04/2022 |
| Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers. | Infection and Immunity | Journal Article | Barton A, Hill J, Bibi S, Chen L, Jones C, Jones E, Camara S, Shrestha S, Jin C, Gibani MM, Dobinson H, Waddington C, Darton TC, Blohmke CJ, Pollard AJ | 21/04/2022 |
| HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells. | Cell Reports | Journal Article, Research Support, Non-U.S. Gov’t | Reuschl A-K, Mesner D, Shivkumar M, Whelan MVX, Pallett LJ, Guerra-Assunção JA, Madansein R, Dullabh KJ, Sigal A, Thornhill JP, Herrera C, Fidler S, Noursadeghi M, Maini MK, Jolly C | 12/04/2022 |
| Host transcriptomic signatures of tuberculosis can predict immune reconstitution inflammatory syndrome in HIV patients. | European Journal of Immunology | Journal Article | Mbandi SK, Painter H, Penn-Nicholson A, Toefy A, Erasmus M, Hanekom WA, Scriba TJ, Lai RPJ, Marais S, Fletcher HA, Meintjes G, Wilkinson RJ, Cotton MF, Pahwa S, Cameron MJ, Nemes E | 09/04/2022 |
| Human serum triggers antibiotic tolerance in Staphylococcus aureus. | Nature Communications | Journal Article | Ledger EVK, Mesnage S, Edwards AM | 19/04/2022 |
| Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. | The Lancet Digital Health | Journal Article, Observational Study, Research Support, Non-U.S. Gov’t | Närhi F, Moonesinghe SR, Shenkin SD, Drake TM, Mulholland RH, Donegan C, Dunning J, Fairfield CJ, Girvan M, Hardwick HE, Ho A, Leeming G, Nguyen-Van-Tam JS, Pius R, Russell CD, Shaw CA, Spencer RG, Turtle L, Openshaw PJM, Baillie JK, Harrison EM, Semple MG, Docherty AB, ISARIC4C investigators | 2022-04 |
| Interventional research to tackle antimicrobial resistance in Low Middle Income Countries in the era of the COVID-19 pandemic: lessons in resilience from an international consortium. | International Journal of Infectious Diseases | Journal Article | Birgand G, Charani E, Ahmad R, Bonaconsa C, Mbamalu O, Nampoothiri V, Surendran S, Weiser TG, Holmes A, Mendelson M, Singh S, ASPIRES study researchers | 2022-04 |
| Outcomes of laboratory-confirmed SARS-CoV-2 infection in the Omicron-driven fourth wave compared with previous waves in the Western Cape Province, South Africa. | Tropical Medicine and International Health | Journal Article | Davies M-A, Kassanjee R, Rosseau P, Morden E, Johnson L, Solomon W, Hsiao N-Y, Hussey H, Meintjes G, Paleker M, Jacobs T, Raubenheimer P, Heekes A, Dane P, Bam J-L, Smith M, Preiser W, Pienaar D, Mendelson M, Naude J, Schrueder N, Mnguni A, Le Roux S, Murie K, Prozesky H, Mahomed H, Rossouw L, Wasserman S, Maughan D, Boloko L, Smith B, Taljaard J, Symons G, Ntusi N, Parker A, Wolter N, Jassat W, Cohen C, Lessells R, Wilkinson RJ, Arendse J, Kariem S, Moodley M, Wolmarans M, Cloete K, Boulle A, Western Cape and South African National Departments of Health in collaboration with the National Institute for Communicable Diseases in South Africa Affiliations | 12/04/2022 |
| Persistent COVID-19 symptoms in a community study of 606,434 people in England | Nature Communications | Article, Journal | Whitaker M, Elliott J, Chadeau-Hyam M, Riley S, Darzi A, Cooke G, Ward H, Elliott P | 12/04/2022 |
| Persistent immunogenicity of integrase defective lentiviral vectors delivering membrane-tethered native-like HIV-1 envelope trimers. | npj Vaccines | Journal Article | Gallinaro A, Pirillo MF, Aldon Y, Cecchetti S, Michelini Z, Tinari A, Borghi M, Canitano A, McKay PF, Bona R, Vescio MF, Grasso F, Blasi M, Baroncelli S, Scarlatti G, LaBranche C, Montefiori D, Klotman ME, Sanders RW, Shattock RJ, Negri D, Cara A | 21/04/2022 |
| SARS-CoV-2 infection and vaccine effectiveness in England (REACT-1): a series of cross-sectional random community surveys. | The Lancet Respiratory Medicine | Journal Article | Chadeau-Hyam M, Wang H, Eales O, Haw D, Bodinier B, Whitaker M, Walters CE, Ainslie KEC, Atchison C, Fronterre C, Diggle PJ, Page AJ, Trotter AJ, Ashby D, Barclay W, Taylor G, Cooke G, Ward H, Darzi A, Riley S, Donnelly CA, Elliott P, COVID-19 Genomics UK consortium | 2022-04 |
| Selection Analysis Identifies Clusters of Unusual Mutational Changes in Omicron Lineage BA.1 That Likely Impact Spike Function. | Molecular Biology and Evolution | Journal Article | Martin DP, Lytras S, Lucaci AG, Maier W, Grüning B, Shank SD, Weaver S, MacLean OA, Orton RJ, Lemey P, Boni MF, Tegally H, Harkins GW, Scheepers C, Bhiman JN, Everatt J, Amoako DG, San JE, Giandhari J, Sigal A, NGS-SA, Williamson C, Hsiao N-Y, von Gottberg A, De Klerk A, Shafer RW, Robertson DL, Wilkinson RJ, Sewell BT, Lessells R, Nekrutenko A, Greaney AJ, Starr TN, Bloom JD, Murrell B, Wilkinson E, Gupta RK, de Oliveira T, Kosakovsky Pond SL | 11/04/2022 |
| Selective clonal persistence of human retroviruses in vivo: Radial chromatin organization, integration site, and host transcription. | Science Advances | Journal Article | Melamed A, Fitzgerald TW, Wang Y, Ma J, Birney E, Bangham CRM | 29/04/2022 |
| Serial measurement of M. tuberculosis in blood from critically-ill patients with HIV-associated tuberculosis. | EBioMedicine | Journal Article | Barr DA, Schutz C, Balfour A, Shey M, Kamariza M, Bertozzi CR, de Wet TJ, Dinkele R, Ward A, Haigh KA, Kanyik J-P, Mizrahi V, Nicol MP, Wilkinson RJ, Lalloo DG, Warner DF, Meintjes G, Davies G | 2022-04 |
| Single-channel digital LAMP multiplexing using Amplification Curve Analysis | Sensors and Diagnostics | Article | Malpartida-Cardenas K, Miglietta L, Peng T, Moniri A, Holmes A, Georgiou P, Rodriguez-Manzano J | 11/04/2022 |
| The compensatory reserve index predicts recurrent shock in patients with severe dengue | BMC Medicine | Article, Journal | Trieu HT, Khanh LP, Ming DKY, Quang CH, Phan TQ, Van VCN, Deniz E, Mulligan J, Wills BA, Moulton S, Yacoub S | 07/04/2022 |
| Towards a marketplace for Vi polysaccharide-conjugate typhoid vaccines. | Lancet Infectious Diseases | Journal Article, Comment | Gibani MM | 2022-04 |
| Update on the Treatment of Pediatric Tuberculous Meningitis. | The Pediatric Infectious Disease Journal | Journal Article | Solomons RS, van Toorn R, Cresswell FV, Seddon JA | 11/04/2022 |