Please join us tomorrow 30/01 for the next round of the Stats reading group at SMH, with journal club + seminar sessions !
All in the MSc students room, ground floor of SMSM building
11am-midday: Paper appraisal by students from the MSc in HDA&ML: “Discovering regulatory and signalling circuits in molecular interaction networks”, T. Ideker et al, BioInformatics, 2002.
In this paper, the authors propose a model for the integration of univariate associations results with protein-protein and protein-DNA interactions stored in large and public databases. The method is based on (i) the construction of a network model using a priori knowledge on molecular interactions and (ii) the estimation of univariate z-scores representing the association of each gene with the outcome. The z-scores are then aggregated for each subnetwork in order to identify the most relevant subnetworks in association with an outcome of interest.
midday-1pm: Seminar by Benno Schwikowski, author of this week’s paper