Category: Infection

TB or not TB?

By final year Imperial Medical PhD student Harriet Gliddon – winner of our Student Challenges Competition 2015/16 

World TB Day (24th March) commemorates the anniversary of Robert Koch’s 1882 discovery of the causative agent of tuberculosis (TB). Since then, it has been the subject of intense research, with hundreds of millions of dollars spent on TB research and development every year. Despite this, we still lack the antibiotics, vaccines and diagnostic tests needed to control the disease properly, and TB therefore remains a major public health challenge, particularly in developing settings like much of sub-Saharan Africa. As of last year, TB is the leading cause of death worldwide due to an infection.

Controlling schistosomiasis: another reason why clean water is so important

By Dr Michael Templeton, Faculty of Engineering, Department of Civil and Environmental Engineering, Imperial College London

With World Water Day approaching on 22 March, research at Imperial College London is highlighting yet another example of why access to clean water is so vitally important to human health.

The research is seeking to quantify the role of access to clean water in reducing the odds of becoming infected with the neglected tropical disease schistosomiasis.

It has been estimated that 200 million people in developing countries are infected with the parasite causing this disease, which manifests itself in a range of symptoms, including enlargement of the liver and spleen, anaemia, increased risk of bladder cancer, exacerbation of the transmission of HIV and its progression to AIDS, and in extreme cases seizures.

SCI needs to expand coverage to help treat 100 million children a year against bilharzia (schistosomiasis) and worms.

By Professor Alan Fenwick OBE, Director of SCI (Schistosomiasis Control Initiative), Imperial College, London)

Schistosomiasis is a type of infection caused by parasites that live in fresh water, such as rivers or lakes, in subtropical and tropical regions worldwide.  It is also known as bilharzia.

The Schistosomiasis Control Initiative (SCI) at Imperial College London supports Ministries of Health and Education in 16 countries to deliver medicines to treat people infected with schistosomiasis and three intestinal worms. The medicines are donated by various pharmaceutical companies, Merck KgGA (praziquantel), GSK (albendazle) and Johnson and Johnson (mebendazole), and for the most part, the targets are school aged children.

IGHI Student Challenges Competition: Diagnosing Schistosomiasis: My Journey so Far…

Gabrielle Prager, Winner of IGHI’s 2013 Student Challenges Competition guides us through her journey throughout the contest and the next steps for her research project.

This is the problem:  In 2011, 243 million people required treatment for schistosomiasis. 28.1 million were reported to have received that treatment. Schistosomiasis is a neglected tropical disease.  What is it? It is a blood dwelling fluke. How is it treated? Mass Drug Administration with Praziquantel has been the mainstay of most treatment programmes. Uganda was the first country in Africa to initiate a national control programme coordinated by the Ministry of Health with technical and financial support from the Schistosomiasis Control Initiative (SCI).