Tag: Prescribing

Why has prescribing of antidepressants increased over the last 30 years?

In a recent post on the platform X, Elon Musk claimed that antidepressants were over-prescribed. In many countries, the prescribing of antidepressants has increased significantly over the past 30 years. During the 1990s, public health campaigns aimed at reducing the stigma surrounding depression encouraged more people to seek treatment. This contributed to a rise in antidepressant prescriptions in countries such as the UK.

Additionally, antidepressants – particularly selective serotonin reuptake inhibitors (SSRIs) – are now widely used not only for depression but also for other conditions such as anxiety disorders, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and chronic pain. This expanded range of indications has been a significant factor in their increased use in recent decades.

One concern regarding antidepressant use is their potential toxicity and their role in suicide. SSRIs are generally considered safer than older antidepressants, such as tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs), which are more likely to be associated with fatal overdoses.

Because of their better safety profile, doctors are more willing to prescribe SSRIs than the older antidepressants. Their relative safety has made SSRIs the preferred choice of drug for many doctors and is also a factor in the increased prescribing of antidepressants.

Antidepressants do play an essential role in managing depression and some other mental health conditions, but over-prescription may occur in some cases due to system-wide barriers like limited access to psychological therapies. Addressing the wider determinants of health is also important. This would include areas such as poverty, housing and access to green spaces and other leisure facilities.

The increase in antidepressant prescribing in the UK has sparked debate about whether they are being over-prescribed. However, antidepressants are a clinically effective option for moderate to severe depression and are now used for a broader range of conditions, such as anxiety disorders and chronic pain. Ensuring a balanced approach, where pharmacological and non-pharmacological treatments are accessible and appropriately used, remains a key goal for improving mental health care in the UK and elsewhere in the world.

Tackling Drug Shortages: An Urgent NHS Priority

The NHS in the UK is grappling with a worsening crisis, drug shortages, as we discuss in our recent article in the British Medical Journal. These shortages have doubled since 2022, with supply disruptions affecting vital medications like antibiotics, diabetes treatments, and hormone replacement therapy. The implications for patient safety and healthcare services are profound, making it imperative for the UK government and the NHS to address this challenge .

Why Are Drug Shortages Happening?

The root causes of these shortages lie in both global and local factors. Disruptions in international supply chains — driven by the COVID-19 pandemic, geopolitical conflicts like the Ukraine war, and rising energy costs — have hampered the production and transport of essential pharmaceutical ingredients. Domestically, the NHS faces challenges such as manufacturing inefficiencies, logistical delays, and regulatory hurdles.

Brexit has also compounded the problem, introducing new trade barriers, customs checks, and currency depreciation, which have made importing medicines more costly and time-consuming. Moreover, economic measures like the Voluntary Scheme for Branded Medicines Pricing and Access (VPAS) have created financial disincentives for pharmaceutical companies to prioritize the UK market.

Impact on Patients and Healthcare Providers

The repercussions of drug shortages are far-reaching. For patients, unavailability of essential medications can lead to delayed treatments, reduced efficacy, and increased risks. For example, shortages of anti-epileptic drugs such as sodium valproate have heightened seizure risks for affected patients. Healthcare providers, meanwhile, face mounting workloads as they try to find alternatives, often dealing with stressed and anxious patients.

Pharmacists, in particular, bear the brunt of these challenges. Many have had to ration medicines or pay inflated prices, which are not fully reimbursed by the NHS. This financial strain comes at a time when community pharmacies are expected to play a larger role in easing the burden on GPs.

Solutions: Immediate and Long-Term Strategies

Addressing drug shortages requires a multifaceted approach:

Regulatory Reforms: Streamlining approval processes and easing restrictions on drug imports could help bridge the gap in supply. Aligning more closely with the European Medicines Agency could mitigate post-Brexit barriers.

Strengthening Supply Chains: Developing better forecasting tools and stockpiling strategies would help anticipate and respond to demand spikes. Investment in domestic pharmaceutical manufacturing, particularly for generic drugs, is also crucial to reducing reliance on global supply chains.

Support for Healthcare Providers: Allowing pharmacists greater flexibility in prescribing alternatives can prevent delays in patient care. Price concessions for scarce medications would also alleviate financial pressures on community pharmacies.

Patient-Centric Interventions: Providing online resources and national helplines to guide patients during shortages can help reduce anxiety and improve adherence to alternative treatment plans.

Looking Ahead

The drug shortages crisis underscores the need for robust policies that prioritise patient care and support healthcare providers. With timely interventions and strategic investments, the NHS can overcome these challenges and safeguard the health of the UK population. Building a healthier population through prevention and reducing demand for medications must also remain a long-term goal. Tackling drug shortages must be a priority for the NHS. Patients deserve reliable access to the medications they need, and healthcare providers need to certain that access to key drugs remains uninterrupted.

Strategies to Address Drug Shortages in the UK’s NHS

In recent years, the UK has repeatedly suffered from shortages of many key drugs. As well as creating extra work for doctors and pharmacists, these shortages are also very stressful for patients. The government has recently published details of how it might address this issue. We need effective implementation of these plans as well. In particular, we need a combination of a strong UK manufacturing base to produce the drugs the NHS needs along with secure contracts with overseas suppliers.

Developing a robust domestic manufacturing base for pharmaceuticals offer several benefits. It reduces reliance on international supply chains, which can be vulnerable to global events, trade disputes, and logistical challenges. UK manufacturing can also facilitate quicker responses to the UK’s health needs and stimulate economic growth and job creation within the UK. However, building such infrastructure requires substantial investment, time, and expertise.

While bolstering domestic production, it is also essential to maintain strong relationships with overseas drug suppliers. Diversifying the source of pharmaceuticals mitigates the risk of shortages due to domestic production issues. Secure, long-term contracts with foreign suppliers can help ensure a steady supply of essential drugs, but these agreements must be carefully managed to ensure they are resilient to global market and political fluctuations.

Relying on the “free market” and a laissez-faire attitude won’t be nearly enough to tackle the problem. Drug manufacturing and supply problems a major global health concern. The UK government should actively engage in international dialogues and collaborations to address wider challenges that impact drug availability.

The costs to the NHS of prescribing for diabetes

Drugs used to treat diabetes are now responsible for 11.4% of total primary care prescribing costs in England, £1,012 million annually. The very high costs to the NHS of treating diabetes are an inevitable consequence of the increase in the prevalence of type 2 diabetes in recent decades. This increase in the prevalence of type 2 diabetes is in turn a consequence of lifestyle factors such as high-calorie diets (particularly diets high in sugars and refined carbohydrates), physical inactivity and obesity. We need effective strategies at both population and individual level, and changes in the obesogenic environment we live in, to reverse these adverse lifestyle- associated factors and bring down the prevalence of type 2 diabetes.

Source: NHS Digital

Telling the truth about antibiotics: benefits, harms and moral duty in prescribing for children

In a paper published in the Journal of Antimicrobial Chemotherapy, we discuss key issues in applying an evidence-based approach to the prescribing of antibiotics to children.

Antimicrobial resistance is a growing threat to global health, yet antibiotics are frequently prescribed in primary care for acute childhood illness, where there is evidence of very limited clinical effectiveness. Moral philosophy supports the need for doctors to consider wider society, including future patients, when treating present individuals, and it is clearly wrong to waste antibiotics in situations where they are largely clinically ineffective at the expense of future generations.

Doctors should feel confident in applying principles of antibiotic stewardship when treating children in primary care, but they must explain these to parents. Provision of accurate, accessible information about the benefits and harms of antibiotics is key to an ethical approach to antimicrobial stewardship and to supporting shared decision making. Openness and honesty about drivers for antibiotic requests and prescribing may further allow parents to have their concerns heard and help clinicians to develop with them an understanding of shared goals.

All this requires adequate time in the consultation; for both a thorough clinical assessment of the child; and a full discussion with the parents about the appropriateness, benefits and risks of antibiotic treatment.

DOI: https://doi.org/10.1093/jac/dky223

Can GPs issue private prescriptions to NHS patients?

The NHS prescription charge in England is currently £8.60 per item. At this level, many commonly prescribed drugs will cost less than the prescription charge and so some NHS patients may occasionally ask if they can have a private prescription rather than an NHS prescription.

In the past, some GPs have been advised that they could issue both an NHS FP10 and a private prescription, and let the patient decide which to use. But the British Medical Association’s General Practice Committee has obtained legal advice that said under the current primary care contract, GPs in England may not issue a private prescription alongside or as an alternative to an NHS FP10 prescription. In any consultation where a GP needs to issue an FP10, the concurrent issue of a private prescription would be a breach of NHS regulations.

The issuing of a private prescription in such circumstances could also be seen as an attempt to deprive the NHS of the funds it would receive from the prescription charge. Furthermore, for private prescriptions, the pharmacist is free to add a dispensing fee to the cost of the drug and so the patient might end up paying the same or even more than the NHS prescription charge for their private prescription. Finally, trying to explain NHS guidance on prescribing and its implications to the patient makes the issuing of a private prescription impractical in the time available.

Hence, I would advise GPs not to issue a private prescription to NHS patients in place of an NHS FP10 prescription in these circumstances. This advice should be communicated to the other prescribers in the practice so that they all follow the same policy.

Of course, the Department of Health could update its guidance and make it easier for NHS GPs in England to issue private prescriptions but there is no currently sign of this happening.

This article was originally published in the medical journal, Pulse.

NHS England’s plan to reduce wasteful and ineffective drug prescriptions

I published an article in the British Medical Journal in August 2017 on NHS England’s plan to reduce wasteful and ineffective drug prescriptions. In the article, I explain why national rules on prescribing are a better approach than the variable local policies being implemented by clinical commissioning groups (CCGs, the NHS organisations responsible for funding local health services).

The National Health Service (NHS) in England must produce around £22 billion of efficiency savings by 2020. A key component of the NHS budget in England is primary care prescribing costs, currently around £9.2 billion annually. Inevitably, the NHS has begun to look at the drugs prescribed by general practitioners to identify areas in which savings could be made; ideally without compromising patient care or worsening health inequalities. This process was initially led by CCGs, focusing on drugs that are either of limited clinical value or which patients can buy from retailers without a prescription (referred to in England as ‘over the counter’ preparations).[1]

However, this local-based approach is flawed.[2] Firstly, CCGs have no legal power to limit the prescribing of drugs by general practitioners. As CCG policies on restricting prescriptions are not backed by statutory guidance, this will inevitably lead to variation between general practitioners in the use of the drugs that CCGs are proposing to restrict, thereby leading to ‘postcode prescribing’. It also raises legal issues in that if there is a complaint about a refusal to issue a prescription, it will be the general practitioner who will have to defend any complaint made by the patient and not the CCG. Each CCG carrying its own evidence review, public and professional consultation, and developing its own implementation policy also results in duplication of effort and is a poor use of NHS resources.[3]

NHS England has now launched its own consultation process to identify areas where ‘wasteful or ineffective’ prescribing can be reduced.[4] However, although a national process is better than local processes, NHS England has not stopped CCGs from continuing to roll-out their own restrictions on prescribing, even though some of these will inevitably conflict with the guidance produced by NHS England when it completes its consultation process.

In its consultation document, NHS England proposes restrictions on prescribing for a range of drugs. Stopping prescribing in some areas – such as homeopathy and herbal remedies – will not be controversial but will also not save much money. Some other drugs that NHS England is proposing to restrict, such as liothyronine, have limited evidence for their benefits but some patients do find them useful, and there will be resistance from patients and from some clinicians about the proposed restrictions on their use.

The two most controversial areas will be around NHS prescriptions for gluten-free foods, for which there was a separate consultation;[5] and NHS prescriptions for drugs available over the counter. In the case of gluten-free foods, these are essential for people with coeliac disease and although gluten-free foods are now much more widely available from retailers than in the past, many patients with coeliac disease continue to receive NHS prescriptions and will resist strongly any restrictions on the availability of gluten-free foods through the NHS[6]. For drugs available over the counter, for example treatments for headlice or hay-fever, many patients will be able to pay for them out-of-pocket. Some poorer patients though will struggle with the costs of buying such drugs.

NHS England is to be congratulated for launching its public consultation and not just leaving decisions about eligibility for NHS treatment to individual CCGs.[7] However, it needs to ensure that its recommendations are accepted by CCGs and that the restrictions on prescribing that some CCGs are trying to impose fall into line with national recommendations. NHS England also needs to make the necessary changes to the National General Practice Contract and to the NHS Drugs Tariff to ensure that any prescribing restrictions it imposes have a firm legal basis. If this is not done, it places general practitioners in the invidious position of being at clinical and legal risk if they adopt NHS England’s prescribing guidance when this is finally published, at a time when they are already under considerable workload pressure.[8,9]

Restrictions on prescribing and the reduced availability of drug treatments on the NHS will have adverse consequences. For example, there is a risk of unintended effects such as codeine-based analgesics being used in place of simpler analgesics like paracetamol or Ibuprofen if the use of the latter is restricted. We also need to ensure that prescribing restrictions do not affect patients with very serious conditions. For example, if restrictions are imposed on NHS prescriptions of laxatives because these are available to buy from retailers, this will impact on patients with cancer, in whom constipation is a common and distressing symptom.

There will also be a risk that poorer patients, who are less able to pay for their own medication, will suffer disproportionately from these restrictions, thereby exacerbating health and social inequalities.[10] Ultimately, however, politicians  and the public must understand that the financial savings the NHS in England needs to make are so large, they cannot be made without substantial cuts to the provision of publicly-funded health services; and without patients making a greater financial contribution to the costs of their health care.[11,12]

doi: https://doi.org/10.1136/bmj.j3679

References
1. North West London Collaboration of Clinical Commissioning Groups. Choosing wisely – changing the way we prescribe. https://www.healthiernorthwestlondon.nhs.uk/news/2017/06/12/choosing-wisely-changing-way-we-prescribe
2. Iacobucci G. Doctors call for national rules on OTC prescribing. BMJ 2017;356:j1442
3. Phizackerley D. National approach to OTC prescribing is needed. BMJ 2017;357:j1849.
4. NHS England. Items which should not be routinely prescribed in primary care: a consultation on guidance for CCGs. https://www.engage.england.nhs.uk/consultation/items-routinely-prescribed/
5. Department of Health. Availability of gluten-free foods on NHS prescription. https://www.gov.uk/government/consultations/availability-of-gluten-free-foods-on-nhs-prescription
6. Kurien M, Sleet S, Sanders DS, Cave J. Should gluten-free foods be available on prescription? BMJ 2017;356:i6810.
7. Iacobucci G. NHS to stop funding homeopathy and some drugs in targeted savings drive BMJ 2017;358:j3560.
8. British Medical Association. BMA responds to NHS England action plan on wasteful drug use. https://www.bma.org.uk/news/media-centre/press-releases/2017/july/bma-responds-to-nhs-england-action-plan-on-wasteful-drug-use
9. Majeed A. Shortage of general practitioners in the NHS. BMJ 2017;358:j3191.
10. Gleed G. Commentary: We’re under financial strain without prescriptions for gluten-free food. BMJ 2017;356:j119.
11. Toynbee P. Feet first, our NHS is limping towards privatization. The Guardian, 16 August 2016. https://www.theguardian.com/commentisfree/2016/aug/16/feet-nhs-limping-towards-privatisation-podiatry-diabetic-amputations
12. Iacobucci G. GPs urge BMA to explore copayments for some services. BMJ 2017;357:j2503.

Perspectives on the management of polypharmacy

A paper published in the journal BMC Family Practice discusses the management of polypharmacy (the concurrent use of multiple medications by one individual). Because of ageing populations, the growth in the number of people with multi-morbidity and greater compliance with disease-specific guidelines, polypharmacy is becoming increasingly common.

Although the correct drug treatment in patients with complex medical problems can improve clinical outcomes, quality of life and life expectancy, polypharmacy is also associated with an increased risk of adverse drug events, some severe enough to result in hospital admission and even death. Hence, having systems in place to ensure that medications are started only when there is a suitable indication, ensuring patients are fully aware of the benefits and complications that may arise from their treatment, and reviewing patients regularly to ensure their medication regime remains appropriate, are essential.

The development and rapid uptake of electronic patient records – particularly in primary care settings where the majority of prescribing takes place – makes monitoring of patients more straightforward than in the past; and allows identification of sub-groups of patients at particularly high risk of adverse drug events and complications. It also facilitates ‘deprescribing’ the process by which medications are reviewed and stopped if not clinically beneficial.

In recent years, we have also seen the development of smartphone ‘apps’ to improve communication between patients and healthcare professionals, improve people’s understanding of their conditions and their treatment, and maintain a record of changes made to patient’s medication. In the longer term, developments such as the introduction of artificial intelligence and clinical decision support systems also have the potential to improve prescribing and minimise the risks from polypharmacy. Finally, there is considerable scope to improve the quality of prescribing and reduce risks from poly-pharmacy using non-medical groups such as pharmacists, specialist nurses and physician assistants.

https://doi.org/10.1186/s12875-017-0642-0