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Wishing for lifelong health for every child

Professor Sejal Saglani

This festive period, Three Wise Women from the Faculty of Medicine give us the gift of wisdom.

Professor Sejal Saglani, Professor of Paediatric Respiratory Medicine in the National Heart and Lung Institute and Director of Imperial’s Centre for Paediatrics and Child Health (PaeCH), shines a light on the pressing need to transform how we understand and manage childhood asthma. She discusses why the youngest children face the greatest challenges, how early-life illness shapes long-term health, and the critical role of research and advocacy in addressing inequalities that begin from birth. Her blog is a call to action: if we are to secure lifelong health, we must begin with the earliest years.

Asthma is the most common long-term condition affecting children of all ages worldwide. In the UK, around 10% of children live with asthma – meaning at least two or three children in every classroom. Among these, those under the age of five face the greatest challenges: they experience the most acute attacks, have the highest number of hospital admissions, and account for 75% of all emergency department visits for childhood asthma. Despite this significant burden, the rate of attacks and hospitalisations have remained unchanged for over 20 years.

This time of year brings the issue into sharp focus. Most admissions occur during the autumn and winter months. Parents and families live in a constant state of vigilance, never knowing whether the next runny nose will simply be a cold or will escalate into yet another visit to hospital with wheezing and breathlessness.

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My journey into addiction research and psychiatry

Professor Anne Lingford-Hughes

This festive period, Three Wise Women from the Faculty of Medicine give us the gift of wisdom.

Professor Anne Lingford-Hughes, Professor of Addiction Biology and previously Head of Division of Psychiatry in the Department of Brain Sciences, reflects on the journey that led her to become one of the UK’s leading experts in addiction psychiatry. From early uncertainty about medicine to pivotal moments in research labs in Cambridge and the US, she describes how scientific curiosity – and a fascination with how alcohol and drugs affect the brain – shaped a career dedicated to understanding and treating addiction.

Brought up in the countryside outside Shrewsbury, I was always interested in science and loved doing school projects. I wasn’t seen as particularly clever at school and was even advised that I didn’t need a “career” – just a job until I got married!

The only interesting university course covering “human biology” was medicine. Although I wasn’t sure about becoming a doctor, I applied. My father, a lawyer who had been to Oxford like his own father, wanted me to go there too, but my school was not exactly encouraging. I applied anyway and failed.

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Weight, hormones and health: Rethinking research for women and older adults

Dr Chioma Izzi-Engbeaya

This festive period, Three Wise Women from the Faculty of Medicine give us the gift of wisdom.

Dr Chioma Izzi-Engbeaya, Honorary Clinical Senior Lecturer in the Department of Metabolism, Digestion and Reproduction and Consultant Endocrinologist at Imperial College Healthcare NHS Trust, explores how decades of research into obesity and metabolic health are beginning to translate into better care for women and older adults – from fertility and menopause to cancer and liver disease. But as she explains, the work is far from over: true progress means making sure no group is left behind.

We live in exciting times. Decades of scientific and clinical research have deepened our understanding of the factors driving metabolic conditions such as obesity and metabolic dysfunction-associated steatotic liver disease (MASLD, also known as ‘fatty liver disease’). 

Alongside this progress, we’ve seen a rapid rise in treatment options for metabolic conditions, with a variety of ever-increasing options on the horizon. However, significant challenges remain. Access to effective treatments is still limited for many people, and there are gaps in the evidence needed to guide how best to manage specific groups of patients. 

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Collaborating across borders to tackle HTLV-1 in Africa


HTLV-1 is a little known but serious virus that can cause life-threatening illnesses, including blood cancer and neurological disease. In many African countries, there is still a lack of research and policies to address it. Dr Carolina Rosadas, Research Fellow in Imperial’s Department of Infectious Disease, writes about bringing together scientists, health officials, policymakers, and community representatives from 18 countries for a groundbreaking workshop in Rwanda – sparking new collaborations, research networks, and strategies to combat this overlooked infection.

Based in the Department of Infectious Disease, I am a Research Fellow focusing on HTLV-1 – an understudied infection that disproportionately impacts underserved communities, particularly in Africa. HTLV-1 can cause severe and often fatal conditions, including blood cancer and neurological disease. There is no treatment for this life-long infection, but prevention is possible.

Despite recent global advances and the formal recognition of HTLV as a priority by the World Health Organization (WHO), many countries in Africa still lack sufficient data and policies to address it. My project aimed to promote local research and help translate knowledge into policy by encouraging multidisciplinary and multi-stakeholder engagement.

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Inspiring tomorrow’s medics at PCSM’s Outreach Day

Dr Mohammed Sabbir Islam and Lord Professor Robert Winston

At a recent Outreach Day hosted by the Pears Cumbria School of Medicine (PCSM) and HelloFutures, Clinical Teaching Fellow Dr Mohammed Sabbir Islam helped local students explore life as a medic—from diagnosing real NHS cases to learning from none other than Lord Robert Winston. In this blog, Dr Islam reflects on a day of sparking ambition, breaking down barriers, and planting seeds for future careers in healthcare.  

The Pears Cumbria School of Medicine (PCSM) recently had the privilege of welcoming local year eight students for a unique outreach day at the University of Cumbria Fusehill Street campus, linked with HelloFutures.  

I am someone who has directly benefited from outreach projects during my journey into medicine and it was a real pleasure to speak, as a young doctor, to kids with whom I identified. 

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Healthy beginnings, hopeful futures: How neonatal research is shaping lifelong health

Dr Cheryl Battersby

Dr Cheryl Battersby, Clinical Senior Lecturer in the School of Public Health and theme lead for Neonatal Medicine at Imperial’s Centre for Paediatrics and Child Health (PaeCH), shares how neonatal research is helping to shape lifelong health outcomes for the most vulnerable babies. From harnessing the power of national data to leading pioneering research programmes, Cheryl and her colleagues are working to ensure that every baby – no matter how early or unwell they are born – has the best possible start in life.

We believe that every child deserves the best start in life, and we know from decades of research and clinical care that the health of a baby in the first days and weeks after birth can shape their entire future.

In the UK alone, around 90,000 babies each year are admitted to neonatal units. Some are born too soon. Others arrive on time but need urgent medical care. These fragile early moments matter. They are the beginning of a lifelong journey.

At Imperial College London, our Neonatal Medicine Research Group is one of the largest academic neonatal centres in the UK. We’re a dynamic team of neonatologists (doctors who specialise in the care of newborn infants), neonatal nurses, statisticians, data scientists, and public involvement experts – working together to transform care for the smallest, sickest newborns.

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Spotlighting Air Quality Researchers on Clean Air Day

Group photo of Aerosol Science Team at Imperial’s Environmental Research Group in front of an air quality monitoring site (Ian is fifth from the left)
Group photo of Aerosol Science Team at Imperial’s Environmental Research Group in front of an air quality monitoring site (Dr Ian Chen is fifth from the left)

Air pollution is linked to 43,000  deaths each year in the UK.  The World Health Organization and the UK Government recognise that air pollution is the largest environmental threat to our health. To mark Clean Air Day, we’re spotlighting Dr Ian (Gang) Chen and Dr Kayla Schulte from Imperial’s Environmental Research Group who are leading the charge in the fight against air pollution. 

Dr Ian (Gang) Chen 

As a kid growing up in China, I always thought the haze was just another humid day with fog. Only after watching the Chinese-made documentary, Under the Dome in 2015, did I realise how polluted our air was. I was shocked and determined to do something about it. To begin my research journey in air pollution, I pursued a two-year MPhil program at the University of Toronto. There, I focused on developing a low-cost sensor to detect soot particles in developing countries. After that, I became interested in identifying and quantifying sources of air pollutants for my PhD studies at ETH Zurich, since it’s the most straightforward way to target emission sources and mitigate air pollution. My research has focused on this topic ever since.  

Our team (Aerosol Science) at Imperial’s Environmental Research Group maintain two air quality supersites in London, where we use the latest technology to continuously monitor pollution. One site is located near Baker Street, central London, a traffic station, while the other is an urban background site located in Honor Oak Park in south London. On Clean Air Day 2023, we launched a particulate matter (PM) dashboard which shows the hourly chemical composition of the solid particles and liquid droplets found in our air.  Making this data open-access and interactive is crucial for public understanding of the air we breathe. The organic mass in PM often contains millions of compounds and my research focuses on identifying and quantifying its sources. In the coming years, we aim to provide near real-time source information for PM on this dashboard, so that both the public and policymakers can understand where the pollution is coming from.  

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Closing the Gender Health Gap: A Call for Sex and Gender Equity in Biomedical Research Policies

When it comes to healthcare, there are clear and stark inequalities between women and men. Marina Politis, Alice Witt, and Kate Womersley explain how, at its root, this gender health gap derives from a research and data gap, and how the MESSAGE project is working to improve accounting of sex and gender dimensions in medical research.

Everyone aspires to receive gold standard treatment when seeking medical care. What if, however, this standard, was only ever set out to be gold for one group of people? Much of our medical evidence base has been based on a male norm, with women underrepresented at all stages of the research pipeline. Subsequently, when a woman suffers an out-of-hospital cardiac arrest, she is less likely to receive bystander CPR than a man. Once in the hospital, she continues to be less likely to receive optimal care than her male counterpart.

The gender health gap in cardiovascular disease – poorer outcomes women experience due to the “male default” in health research and healthcare – is just one of many conditions for which there are disparities between women and men. From dementia to diabetes, and osteoporosis to obesity, sex and gender differences and similarities remain neglected in UK and international research.

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Why not eliminate HTLV-1 while eliminating HIV-1? We need HTLV-1 PEP/PrEP clinical trials.

Dr Goedele Maertens and Dr Fabiola Martin

HTLV-1 PrEP Open Letter to Gilead & ViiV 

Human T Lymphotropic/Leukaemia Virus-1 (HTLV-1) is a sexually transmitted infection (STI) closely related to human immunodeficiency virus-1 (HIV-1). HTLV-1 causes chronic infection, can be transmitted from mother to baby and is associated with significant disease burden and mortality, preceded by years of suffering and poor quality of life for victims.   

Therefore, HTLV-1 is one of the 2030 elimination targets of the World Health Organization’s global STI elimination strategy.  

Although there is currently no drug or vaccine available to cure HTLV-1, we now know that the very same drugs that effectively treat patients with HIV or prevent people from getting HIV-1, called HIV PrEP, also prevent the transmission of HTLV-1 in our laboratory testing (Reviewed in Bradshaw and Taylor, Frontiers in Medicine 2022). We believe that these compounds are likely to block the transmission from mother to child. 

It is well known that many HIV PrEP clinical trials are conducted in countries where HTLV-1 is common. So, by adding in HTLV-1 testing to these HIV-PrEP trials we could measure if the HIV PrEP drugs also prevent HTLV-1 transmission. The beauty of such an outcome would be that these HIV-1 drugs are already licensed to be used in humans.  

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Sharing dumplings, jetlag and the stage: co-presenting at conferences, the way forward

Dr Lindsay Dewa, Advanced Research Fellow in Mental Health, and Pelumi Fatayo, co-producer of Nexus, reflect on their experiences of presenting together at an international conference, and the value of putting co-production into practice. 

“Oof – long day that wasn’t it! Is it 11pm or 7am? Is it Friday or Saturday? I’m so confused!” – Lindsay

That was a question I had asked Pelumi following over 24 hours of travelling from London (and Manchester for Pelumi) to South Korea. But I could see it was already well worth the trip before we’d even stepped out of the taxi – the bright lights, the heat… the friendly taxi driver trying to figure out where our hotel was on his five digital devices… we were excited! But what I was most looking forward to was co-presenting about co-production in mental health research at a prestigious international conference – ISQua – with one of my young co-producers, Pelumi. The conference theme was “Technology, culture and co-production: Looking to the horizon of quality and safety” so we felt it was perfect for us to share our experiences.

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