This festive period, Three Wise Women from the Faculty of Medicine will be giving us the gift of wisdom.
The journey to becoming a clinical academic can be long and arduous, with many obstacles. Dr Maddalena Ardissino, from the National Heart and Lung Institute, reflects on her own experiences as a trainee and explains why mentorship is key to supporting the growth and development of young, aspiring clinical academics.
Almost exactly five years ago, I stood amongst a crowd of young academics at a poster session at the Intensive Care Society’s annual conference, experiencing a feeling of anxiety I’ve never known before or since. I was in my fifth year of medical school and standing in front of a group of excellent researchers who were about to listen to me give my first scientific presentation. It seemed unthinkable to me, at the time, to think that they might have the slightest interest in what I had to say.
Since then, my journey through clinical and academic training has been what I can only describe as an adventure. I quickly realised that there isn’t a single defined path for clinical academics, with each individual moulding a slightly different journey. When I look around at my fellow clinical academics at the National Heart and Lung Institute, however, there is one key feature that we all share: enthusiasm. And behind this feature there is one single, common theme: the support of a truly inspirational mentor.
Providing the most comprehensive picture of COVID-19 infectiousness to date, recent researchfrom Imperial College scientists offered new insights into how long people with COVID-19 are infectious for. Co-author, Dr Seran Hakki, outlines the challenges of collecting real-world evidence in the first-of-its-kind study.
In August, the ATACCC Study (The Assessment of Transmission and Contagiousness of COVID-19 in Contacts) published some of their findings in one of the world’s leading respiratory health journals, The Lancet Respiratory Medicine. Our study was the first to use real-life evidence from naturally acquired infection to assess the duration of COVID-19 infectiousness, its correlation with symptom onset, and how this affects the accuracy of lateral flow tests.
PhD students Salina Nicoleau & Maike Haensel outline their vision for The Elevat(Her) Podcast and share the importance of highlighting positive female role models to empower other women to achieve their full potential.
Look around you – how many women are in senior positions across your university? Lucky you if you can count more than a couple. According to a recent report by the Higher Education Statistics Agency (HESA), women account for only 28% of professors in UK universities in 2020/21 (1). This is a recurring theme within many sectors, not just higher education, where there are fewer women than men in senior positions. In 2021, the number of female Fortune 500 CEOs was only 41. Yes, out of 500 CEOs, 459 were men (2).
Dr Fouzia Haneef Khan, Teaching Fellow on the MSc Genes, Drugs and Stem Cells – Novel Therapies programme, outlines her recommendations to create an effective partnership as mentor and mentee.
Over the past seven years, I have had a variety of teaching experiences, some excellent, some awful, and some in between. Thinking about the start of my teaching journey, I remembered feeling slightly unconfident when delivering a teaching session, with a sense of doubt about whether I was reaching my potential to give the best learning experience to students. However, with the help of more experienced colleagues, I feel that I have significantly improved in these areas. These mentors have supported me on my journey by giving specific and useful recommendations about teaching strategies and general career advice.
The most important aspect of this relationship to me is that I know that I can rely on someone who is experienced in the field and has gone through similar challenges as I have. Underlying this mutual respect and trust is a feeling of genuine friendship.
Dr Emma Smith—HIC-Vac Network Manager—explains how specific guidelines for the provenance and manufacture of challenge agents could make human infection studies even safer.
Human infection studies, also known as human challenge studies, are clinical trials where volunteers are intentionally given a carefully considered dose of a pathogen—known as the challenge agent. These models can be used to study host-pathogen interactions and disease progression; identify and test the efficacy of promising vaccines and drugs in development; or be used as proof-of-concept studies for testing novel medications. In this controlled environment it is possible to study infections in ways that aren’t possible in traditional field studies.
One of the first steps towards establishing a challenge study is the selection, isolation, development and production of the challenge agent. However, unlike medicines, the regulation of challenge agent manufacture varies internationally; an area that the research community has identified as a potential weakness in the field. Although human challenge studies have an excellent safety record—a recent literature review identified just 24 Serious Adverse Events (SAE) and zero deaths or cases of permanent damage among 15,046 participants in 308 studies spanning 1980 to 2021— the lack of specific guidelines for the provenance and manufacture of challenge agents warrants attention.
HIC-Vac—an Imperial-led international network of researchers who are developing human infection challenge studies—has been working with the global charitable foundation Wellcome and the company hVIVO to address this unmet need. Our purpose was to promote volunteer safety whilst maximizing access to challenge agents and challenge models globally. (more…)
Dr Paz Tayal reflects on her experience in the L’Oréal-UNESCO For Women in Science Rising Talent Awards.
Do we even need an award for ‘Women in Science’? Shouldn’t there be a similar award for men in science? Well, depends on how you look at it, but you could argue all awards over the past 1000 years have been for ‘Men in Science’.
The L’Oréal-UNESCO For Women in Science Rising Talent Programme has promoted women in scientific research on a global scale since 1998. The L’Oréal-UNESCO UK and Ireland For Women in Science Programme offer awards from a partnership between L’Oréal-UNESCO UK & Ireland, the UK National Commission for UNESCO and the Irish National Commission for UNESCO, with the support of the Royal Society, to promote, enhance and encourage the contribution of women pursuing their research careers in the UK or Ireland. (more…)
Dr Paul Turner, Consultant in Paediatric Allergy and Immunology at Imperial College London, and Ayah Wafi, Allergen Risk Assessor at the Food Standards Agency, introduce a new national reporting platform for allergic reactions. Funded by the Food Standards Agency (FSA) with contributions from Food Standards Scotland (FSS), the UK Anaphylaxis Registry will provide more data on levels of anaphylactic reactions in the UK.
Today sees the launch of the UK Anaphylaxis Registry at the Annual Conference of the British Society for Allergy and Clinical Immunology (BSACI).
The establishment of a registry represents an important step in better understanding anaphylaxis and how allergic reactions impact individuals in the UK.
An anaphylaxis reaction is a serious, and potentially life-threatening allergic reaction. Whilst severe or fatal anaphylaxis is rare, food-allergic reactions due to accidental exposure are common in people with a food allergy.
Until the launch of the registry, we have not had a standardised way of reporting these reactions in the UK. The registry will serve as a platform for clinicians to record details of anaphylaxis incidents, and collate data from across the UK to provide a better picture of the type of reactions, their frequency and their geographic spread.
On Mesothelioma Awareness Day, Dr Anca Nastase provides an insight into mesothelioma and how research advances offer new hope for improved treatment.
Mesothelioma Awareness Day represents a great opportunity to gain more information about the disease biology, risk factors or symptoms from everyone in the mesothelioma community. Raising awareness is essential as it has the potential to improve prevention and early diagnosis and can translate into better outcomes and better survival for the patients.
My aim as a scientist within the National Centre for Mesothelioma Research (NCMR) is to deepen the molecular research in mesothelioma and to advance our understanding of the mechanisms responsible for the onset and progression of this disease.
Although progress has been made in the field, further understanding of the pathophysiology is still desperately needed.
Mesothelioma is a type of cancer that arises and develops in the thin layer that covers the human internal organs, called mesothelium.
Firstly, I think it is incredible that HDRUK recognises the lack of black people within health data science and has given us, interns, the opportunity to explore this sector. Why is it important to have diversity within health data science? Increasing diversity increases the ability to fight against systemic racism and discrimination. This is an ongoing battle, and it is so important that everyone plays their part in challenging it.
During these last six weeks I, have had many experiences such as listening to various talks, working on my own projects, and meeting some amazing, knowledgeable people. (more…)
The pandemic has been a huge challenge for people with lung disease – Dr Nick Hopkinson outlines what needs to change to provide them with the required support.
The COVID-19 pandemic has had a double impact on people with lung disease – both the impact of the condition itself as well as measures to avoid it on individuals and the impact on access to healthcare. COVID-19 is a respiratory infection, with people with COPD and severe asthma among those who are the most vulnerable. Many people with these conditions have spent a year shielding to avoid it.