Author: David Nutt

Guide to Sober October: what’s in it for you?

David Nutt

This month, people worldwide will take on the 31-day ‘Sober October’ challenge, a movement that began in the UK to raise funds for Macmillan Cancer Support, benefiting those with cancer. Even if you’re not officially participating, Sober October offers a chance to reset your body and rethink your relationship with alcohol. In our latest blog, Professor David Nutt from the Department of Brain Sciences shares expert tips on how to make the most of this healthy, alcohol-free month.


Sober October is here, and it’s the perfect opportunity to hit reset on your relationship with alcohol – whether you’re looking to completely abstain or simply cut down. Much like Dry January or Dry July, this month-long challenge is about taking a break from alcohol and reassessing its place in your life.

With alcohol consumption on the decline among Gen Z and Millennials, it’s clear that more and more people are recognising the benefits of taking a break from booze and now is the perfect time to jump on board.

Sober October is a global movement encouraging people to stop drinking for the month of October. For many, it’s a time to take a break and rest after summer’s social gatherings and prepare for the end of year holiday season with a clearer mind. It’s not just about abstinence; it’s also about fostering better health, improving mental clarity, and building positive habits for the future.

Progress not perfection

Stopping alcohol intake for a whole month can have major health benefits.  People who participated in previous abstinence challenges like Dry January have reported improved sleep (56%), weight loss (38%), and better mental health. Even those who didn’t make it through the full month still saw long-term reductions in alcohol intake and enhanced well-being, showing that it’s about progress, not perfection.  There are also likely to be measurable physiological improvements such as lowering your blood pressure if you are hypertensive, losing weight (as alcohol has more calories than most people imagine) and putting more money in your pocket – perfect for upcoming holiday shopping.

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Psychedelics – how modern neuroscience research is leading to new treatments for brain disorders

Psychedelic therapies have the potential to vastly improve the treatment of mental health disorders such as depression. The Imperial Centre for Psychedelic Research is paving the way in exploring these innovate treatments using psilocybin – the active ingredient in magic mushrooms. Here, Professor David Nutt from the Department of Brain Sciences discusses. 


When most people think of psychedelics, the first thing that comes to mind is LSD-inspired Flower Power during the 1967 Summer of Love in the USA, with its associated revolution in art and music. This explosion of use was seen to be fuelling the protests against the war in Vietnam and so rapidly led to LSD and related psychedelics such as psilocybin (the active ingredient in magic mushroom) being banned, first in the USA and then later globally. This ban still exists today and has effectively censored research for over 50 years. The ban is very unfortunate as prior to this there were hundreds of studies that showed psychedelics were effective treatments for a range of mental illnesses as well as some other brain disorders. Millions of patients may therefore been denied access to potentially life-saving treatments.

This situation is beginning to change with several universities setting up psychedelic research groups including the Centre for Psychedelic Research at Imperial, which was the first and is now five years old. The impetus to these new research centres is twofold. First, today we have much more powerful neuroimaging methods to examine the impact of psychedelics on the brain and second, these neuroimaging studies have revealed possible mechanisms underpinning the therapeutic activity of psychedelic drugs, so encouraging more clinical research. This research has revealed remarkable efficacy in a number of patients who have not responded to prior conventional treatments and may be the start of a whole new phase of novel therapies for mental illnesses.

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Alcohol Awareness Week: seeking a responsible alternative

For Alcohol Awareness Week, Professor David Nutt explains how his latest research venture, an alcohol-free beverage, could address the dangers associated with alcohol consumption. 


Most of us are aware that chronic, heavy alcohol consumption and binge drinking leads to a plethora of health issues including liver damage and addiction. However, many of us are still unaware of the dangers associated with even moderate alcohol consumption or the cumulative effects that alcohol can have on our health. So just what are those regular trips to the pub, or the frequent cocktails after work really costing us? (more…)