Tag: AMR

Better, quicker and more effective treatment for patients with sepsis

Sepsis kills five people every hour and accounts for about 50,000 deaths per year in the UK alone. To mark World Sepsis Day, Professor Anthony Gordon, Chief Investigator of the SepTiC study and Head of the Division of Anaesthetics, Pain Medicine and Intensive Care (APMIC), who is also a consultant in intensive care medicine and NIHR Senior Investigator, sheds light on how the study aims to find more effective treatment for sepsis patients.

Sepsis is one of the most serious conditions medical teams deal with. It’s life threatening and always considered a medical emergency. We don’t fully understand why it effects some people at different times but we do know it is caused by the immune system having an extreme response to an infection, most commonly due to an infection caused by bacteria. This causes organs to stop working properly and the body to damage itself because of that immune response, sometimes leading to multiple organ failure.

Patients with sepsis can deteriorate rapidly and this can sometimes be difficult to spot because the symptoms, such as fever, pain and breathlessness, are common to many other diseases. Anything we can do to improve care for these patients is vital to improving outcomes.

For patients receiving critical care in the intensive care unit, this can be even more challenging because they aren’t always able to tell us how they are feeling. But these patients are also at the highest risk because they are already so unwell.

This is why research to refine and improve treatments for sepsis is so vital – so we can respond as quickly as possible, in the most effective way, to help more patients make a full recovery, without lasting side effects.

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The Fleming Centre: Driving the fight against antimicrobial resistance.

Prof Ara Darzi, Chair, The Fleming Centre Initiative 

In the relentless pursuit of global health, few adversaries loom as large as antimicrobial resistance (AMR). AMR poses a pervasive threat to both different disease areas and public health as a whole. It has the potential to undermine modern medicine, as previously treatable common infections and injuries may once again become life-threatening. As the gravity of this crisis intensifies, The Fleming Centre will stand at the forefront of a burgeoning global movement to combat AMR. On World Antimicrobial Awareness Week,  Professor Ara Darzi, Chair of The Fleming Centre Initiative, writes about the pivotal role this centre will play in the fight against AMR and the far-reaching impact it promises to deliver.  

AMR poses a significant threat to global health, making it one of the most pressing challenges of our time. Drug-resistant infections occur when the bacteria responsible for the adaption and evolution of infections, gain the capacity to withstand drugs intended to kill them. The overuse and misuse of antimicrobial drugs, such as antibiotics and antifungals, in both humans and animals is only accelerating this process. As a result, AMR has been linked to more than one million deaths worldwide each year; a sign common infections are becoming increasingly difficult to treat as the medicines we all rely on become less effective. With people across the globe already dying from drug-resistant infections, the threat of more drugs losing their potency, will put more lives at risk.  

Deaths attributed to AMR every year
Source: Wellcome Trust (https://wellcome.org/sites/default/files/wellcome-global-response-amr-report.pdf)

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A social science approach to tackling antimicrobial resistance

This World Antimicrobial Awareness Week, Dr Esmita Charani discusses co-developing a Massive Open Online Course on how a social science perspective can fight the problem of antimicrobial resistance.

As part of an ESRC funded international research programme investigating antibiotic use in surgical care, we had the opportunity to collaborate with another ESRC funded research team at the University of Oxford to develop an e-learning course to share the learning from the methods we used and the findings of our work.

Partnering with the British Society for Antimicrobial Chemotherapy (BSAC), we developed a Massive Open Online Course (MOOC), focusing on how we can use qualitative research to capture what challenges healthcare workers face in optimising antibiotic use in different countries. Working with our international collaborators and colleagues, we brought together a multidisciplinary expert faculty. (more…)