Tag: Research

My day in the living lab: Could I help accelerate drug trials?

Rory-Cellan-Jones

Rory Cellan-Jones is an author and former BBC Technology Correspondent who, in 2019, was diagnosed with Parkinson’s Disease. Rory discusses his visit to the ‘Living Lab’ at the UK DRI Care Research & Technology Centre – a unique mock apartment where scientists can monitor the behaviour of patients in a domestic environment.

My week started with quite a stressful day. For nearly five hours I was under the microscope, my every move watched by scientists. They made me walk up and down, rise from a chair without using my arms, open and close my hand rapidly. I spent half an hour staring at a computer screen trying to work out which shape fitted where on a grid, one of a number of cognition tests. They even made me make two cups of tea and four slices of toast.

It was tiring but it was all in the cause of science – and potentially faster drug trials. This all took place in Imperial College’s Living Lab, a room fitted out like a small flat on the ninth floor of a tower block in West London. The lab is equipped with video cameras and a series of sensors which provide data on its occupants’ activities.

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Medical cannabis for chronic health conditions: hype or hope?

A small pile of medical cannabis on a dish

It’s been over four years since the UK legalised the medical use of cannabis. Despite this, attitudes towards its use remains a hot topic for patients and health professionals alike. Dr Simon Erridge from the Department of Surgery and Cancer separates fact from fiction about the prescribing of medical cannabis for health conditions such as chronic pain and anxiety.

Since 2018, medical cannabis has been available legally on prescription for patients here in the UK. However, many people are not aware of this and our research in 2021 suggested that almost 50% of UK adults are unaware that medical cannabis is legal in the UK. Many more may be unsure as to what medical cannabis is, when it can be prescribed, and what the medical evidence says about its effects. Despite this, there is a lot of promise held about the potential of medical cannabis and its use in healthcare in the future.

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Expansion of London’s Ultra Low Emission Zone (ULEZ): why is it causing so much controversy?

ULEZ zone in London

There is nowhere in London that meets the World Health Organization’s (WHO) Air Quality Guidelines (AQGs). The main reason for this is road traffic. So why has the Mayor’s plan to expand the Ultra Low Emission Zone (ULEZ; an area of London that more polluting vehicles have to pay £12.50 to enter) to include the outer London boroughs sparked so much resistance? Professor Frank Kelly who leads the Environmental Research Group at Imperial explains that there are strong health grounds for expanding the ULEZ.

An overwhelming body of evidence exists that the health effects of air pollution are serious and can affect nearly every organ of the body. Recent studies and large research programmes have also shown that these harmful health effects are not limited to high exposures but can also occur at very low concentrations. Consequently, the WHO has had to update its AQGs, which now recommend substantially lower air quality limits for PM2.5, PM10 (particulate matter less than 2.5 and 10 μm in diameter respectively), and the gaseous pollutant nitrogen dioxide. One of the most significant sources of these air pollutants in urban areas is road traffic. It is also the source that has repeatedly been shown to affect our health. In London this is particularly true because of the size of its population and the density of its road network.

Is an H5N1 ‘bird flu’ pandemic inevitable?

The largest ever outbreak of bird flu is spilling over into mammals, including foxes and otters in the UK. Could this transmission see a jump to humans? Dr Thomas Peacock from the Department of Infectious Disease discusses.

Avian influenza virus has been featured prominently in the news again over the past few months. Headlines urge vaccine stockpiling, show images of beaches covered in dead sea birds or seals, or people in hazmat suits carrying bin bags full of dead birds or mink. Three years into the COVID-19 pandemic, is another pandemic unavoidable?

We have been in this situation before, back in the late 1990s and early 2000s, headlines spoke of ‘bird flu’ – H5N1 viruses ancestral to the ones currently circulating in Europe – as the inevitable coming pandemic. In fact, in 2009 an influenza pandemic did occur, but rather than the deadly H5N1 bird flu, it was caused by an obscure swine influenza virus that passed onto humans and caused the 2009 ‘swine flu’ pandemic.

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Academic Women Association: a new women network at Imperial

Academic Women Association

How can we close the gender gap in STEM? Dr Ilaria Belluomo explores how a new network at Imperial aims to provide a safe space for women to discuss and plan their careers in leadership roles – in and outside academia.

We are all aware of the disparity between the number of men and women in senior academic positions, as well as the limited number of female mentors available to support and inspire young girls interested in pursuing a career in science. This small percentage of female representation can give the impression that a career in science and academia, in the current climate, can be difficult and hard for women to pursue. Things are slowly improving, but we are only at the beginning of initiating this change. We continue to have conversations and work on initiatives to ensure that the academic gender gap can be improved.

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Lunch is up for London school kids. What are the implications of the universal free school meals policy in London?

Girl holding tray of food in school canteen

As well as providing vital relief to disadvantaged children and families, free school meals are essential to ensuring children reach their full potential, writes Dr Jennie Parnham from the School of Public Health.

On 19th February 2023, the Mayor of London, Sadiq Kahn, announced plans to provide free school meals to all primary schoolchildren (ages 4-11 years) in London.

In England only infant schoolchildren (4-7 years) are given universal free school meals (UFSM). For older children, free school meals are means-tested and are only available to households receiving Universal Credit (with incomes <£7,400/year). The remaining children must pay for school meals.

This policy will dramatically expand the current free school meal provision in London, reaching 270,000 children at a cost of £130 million. But what will this unprecedented policy announcement mean for children, their families, and our wider society?

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Exploring Community-Based Care and Support Networks for Frail People

Many of us will need support as we age but who exactly provides that care? Dr David Sunkersing offers new insights into the support networks of frail people.

Frailty is a clinical syndrome, most common in older adults and associated with an increased risk of adverse health outcomes including falls, hospitalisation and reduced survival time. Many frail individuals therefore rely on family, friends, groups, healthcare professionals, carers and others to assist with their care and support needs and maintain both their independence and quality of life (a care and support network).

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Inspirational leadership matters: supporting the next generation of clinical academics

Dr Maddalena Ardissino

This festive period, Three Wise Women from the Faculty of Medicine will be giving us the gift of wisdom.

The journey to becoming a clinical academic can be long and arduous, with many obstacles. Dr Maddalena Ardissino, from the National Heart and Lung Institute, reflects on her own experiences as a trainee and explains why mentorship is key to supporting the growth and development of young, aspiring clinical academics.

Almost exactly five years ago, I stood amongst a crowd of young academics at a poster session at the Intensive Care Society’s annual conference, experiencing a feeling of anxiety I’ve never known before or since. I was in my fifth year of medical school and standing in front of a group of excellent researchers who were about to listen to me give my first scientific presentation. It seemed unthinkable to me, at the time, to think that they might have the slightest interest in what I had to say.

Since then, my journey through clinical and academic training has been what I can only describe as an adventure. I quickly realised that there isn’t a single defined path for clinical academics, with each individual moulding a slightly different journey. When I look around at my fellow clinical academics at the National Heart and Lung Institute, however, there is one key feature that we all share: enthusiasm. And behind this feature there is one single, common theme: the support of a truly inspirational mentor.

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World AIDS Day: We have come a very long way but there is still much to do to protect those at risk

Professor Sarah Fidler

This festive period Three Wise Women from the Faculty of Medicine will be giving us the gift of wisdom.

While HIV is no longer the death sentence that it once was, lifelong treatment is still required and there is no cure – yet. Professor Sarah Fidler from the Department of Infectious Disease discusses how a new type of HIV treatment holds promise as a longer-lasting alternative to current complex drug regimens.

Despite extraordinary political and medical advances, HIV, the virus that causes AIDS, remains one of the world’s most serious public health challenges. Since its discovery in 1983 by researchers at the Pasteur Institute in France, 84 million people worldwide are estimated to have become HIV-positive and 40 million people have died from an HIV-related illness. Today, there are around 38 million people living with HIV globally, with 1.5 million new infections in 2021.

Advocacy and close collaboration between clinicians, scientists and the HIV-affected community has inspired and driven the research and drug development and access agenda. Without these close working relationships, the development of HIV treatments would have been markedly slower and many more lives would have been lost.

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Targeting both incretin receptors together for a new generation of diabetes therapies

Close up of woman's hands checking blood sugar level using glucose meter

Dr Alejandra Tomas, Senior Lecturer at the Department of Metabolism, Digestion and Reproduction, explores new and emerging incretin-based therapies for managing diabetes.

Diabetes is a disease that has reached epidemic proportions, with millions of people dying or suffering from a myriad of associated complications. Given that cases are projected to increase worldwide over the coming decades – especially in low- and middle-income countries – there is an urgent need to develop and deploy effective treatments for the disease.

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