Dr Peter Sarkies explains how network-based visualisation has revealed new insights into a genome feature known as a transposable element.
When we think of a scientific discovery, we typically imagine a “eureka” moment, in which someone in a white coat glimpses the result of an experiment and in one stroke, solves one of life’s major questions. However, it is important to realise that a key aspect of scientific progress involves the development of new tools that help make previously insoluble research questions accessible. One important example of this is tools that help scientists to see better. We’re all familiar with many of these tools and how they were instrumental in biology – from the microscope that enabled cells to be seen for the first time, through to more recent tools such as electron microscopy that made visible the fine inner structure of the cell, and X-ray crystallography enabling scientists to work out the position of each atom in a protein. What might be a little less obvious is how important more abstract modes of visualisation can be in helping scientists to make progress in understanding research questions. (more…)
The pandemic has been a huge challenge for people with lung disease – Dr Nick Hopkinson outlines what needs to change to provide them with the required support.
The COVID-19 pandemic has had a double impact on people with lung disease – both the impact of the condition itself as well as measures to avoid it on individuals and the impact on access to healthcare. COVID-19 is a respiratory infection, with people with COPD and severe asthma among those who are the most vulnerable. Many people with these conditions have spent a year shielding to avoid it.
On Clinical Trials Day, Fran Husson discusses how receiving treatment for Acute Myeloblastic Leukaemia made her aware of the value and impact of research.
It is impossible, as a patient, not to think “vaccination” when asked to engage in some reflection about “Research”. Vaccines would not have been created so swiftly to combat Sars-CoV-2 if strong and well established multi-disciplinary cohorts of researchers, within prominent academic institutions, had not been in place to mastermind clinical trials and produce an effective immunisation response to the pandemic.
This begs the question of Patient and Public awareness of research, whether for clinical purposes or service delivery of health and social care. Do we need such a devastating global pandemic to raise the profile of research?
In my case, a late diagnosis of Acute Myeloblastic Leukaemia provided the lightning bolt to make me aware of research. Hospitalised in isolation for ten months, under round-the-clock treatment from clinicians who also involved me in different clinical research projects, I could not but appreciate the full value and impact of research. (more…)
Jenny Shelton takes us through the incredible potential of fungi and how this diverse, yet often overlooked, species may hold many of the answers to global challenges, from climate change to food insecurity.
Fungi play important roles in nature, food production, medicine, industry and bioremediation yet we have only discovered ~150,000 out of a potential 6.3 million fungal species. Just recently, a PhD student found undiscovered fungal species in seeds stored at the Millennium Seed Bank and estimates the whole collection might contain up to 1 million new species! You might be surprised to learn that fungi are more closely related to animals, and therefore humans, than they are to plants, and that the combined biomass of all fungi on Earth is 200 times greater than the entire human race.
The responses I often get when I tell someone I’m a mycologist is “Eurgh, I hate mushrooms!” or “Can you cure my athlete’s foot infection?”. It’s no surprise that this is their reaction given how little fungi feature in the U.K. school curriculum, or even in most biology and medical degrees, but it is such a shame given how magnificently diverse the Kingdom of Fungi is. (These responses also, unknowingly, capture the yin and yang of fungi: while this article is about the good that they can do it is important to acknowledge that fungal infections cause misery to millions of people around the world every year.)
Keeping in mind the challenges facing us – climate change, global food insecurity and infectious disease pandemics –I hope you will agree with me that the solutions to many of our problems could be fungal! (more…)
Back in 2011, I was telling a senior consultant in Public Health about Brazil’s extraordinary primary care system which is based on an army of over 250k community health workers (CHW). It had been established in the northeast of the country in the mid-1990s, in response to a cholera epidemic, and since had scaled nationally, now serving over 70% of the population. The principles seemed simple enough. Individuals from a neighbourhood are recruited and trained on a wide array of health and social care issues for a few weeks and then spend their working days visiting all the households that they are responsible for. Not many households, just around 200 each, but each CHW makes sure that the households get at least one visit per month. (more…)
Dr Francesca Conway takes us through a typical week as a clinical research fellow and how her previous time at Imperial contributed to her developing an interest in a career in clinical academia.
6am. I’m awakened by the horrifically jolly alarm tone on my phone. It’s still dark, it’s still raining, and it’s still cold. Hedgehogs have the right idea hibernating over winter, I think, as I haul myself out of bed. Must consider this hibernation proposition in my next supervisor meeting. 1 shower, 1 yoghurt and 3 smoothies later and I’m in the hospital.
Today I have a patient coming to see if she is eligible to be recruited to the clinical trial which forms part of my PhD. Mrs X has travelled from 300 miles away. She greets me with a smile and tells me how pleased she is to be here. I immediately remember why I love my job, and scrap the idea of hibernation. I offer her a coffee, she gratefully accepts and whispers, could I have an extra shot in that? I assume she means coffee. I wonder what time she woke up, but am pretty sure it was before 6am.
I am researching a potential new treatment for Chronic Cbstructive Pulmonary Disease (COPD) for my PhD. Mrs X suffers with COPD, a disease affecting the lungs most commonly caused by smoking. More than 3 million people die from it each year. Targeted Lung Denervation or “TLD”, is a non-surgical procedure where we deliver energy to the airways using a system made by Nuvaira, a US-based company. The idea is that the energy disrupts the nerve supply to the lungs, so the airways relax and open. With initial data looking promising, we hope that this will lead to improvements in health for patients like Mrs X. More information on the Airflow website. (more…)
For Imperial’s Sustainability Week, medical student Urvi highlights the environmental impact of abandoned face masks.
This pandemic has unexpectedly impacted the entire world in more ways than one. Despite a whole year having passed in what feels like the blink of an eye, so many historic moments have occurred over the past year, ranging from huge political changes to unrest and activism. It’s given us a lot to reflect on and I know that I personally have realised how there is so much we can do to strive to make this world a better place.
Other than grocery shopping, leaving my house for a walk is unfortunately the only kind of outing I’ve had these days. It dawned upon me how wrongly accustomed I had become to seeing masks and gloves littered and trodden into the pavement and grass near where I lived. I don’t remember there being so much litter in my neighbourhood before. I couldn’t help but think that if this is the case in our cities and towns, imagine how many masks and gloves would be littering our beaches and rivers, let alone our oceans…
As Lauren Headley-Morris nears the end of her PhD, she reflects on the experience gained and why learning won’t stop after she’s completed her terminal degree.
Terminal is a weird word. Usually heard on TV associated with cancer, you wouldn’t necessarily want a degree that is terminal. Some days I think my PhD is the best thing since the sequencing of the human genome; other days I think it might be the death of my love of science. But terminal is used in some less, erm, disastrous, melodramatic? scary? ways.
One of these less-morbid settings is travel. A PhD is, by nature, the end of the line of academic qualifications. It doesn’t mean you’ve now mastered your subject, sadly. There are post-doc positions and even professorships in the future perhaps.
I’m a third-year, Asthma UK funded, Clinical Medical Research PhD student based at the Guy Scadding Building, Royal Brompton campus. My work is focused on transcriptional regulation in asthma. While my day to day is obsessing about microRNA and things that are too tiny to see, I think it’s important to take a second now and then to sit back and reflect on the bigger picture of where my PhD fits in with my life as a whole. Maybe it’s the effect of spending so much time in isolation or maybe, coming to the end of my formal academic training, I’m getting a little philosophical. (more…)
Recent graduate Samuel Badru is part of the lab team analysing samples for Imperial’s in-house Covid-19 testing scheme – here he shares the steps to processing a successful test.
I would have never guessed that five months into studying a Master’s in Molecular Biology and Pathology of Viruses, the world would be stopped in its track on account of a virus. Lockdown descended on the nation two weeks into my project, which for me meant more bioinformatics from home and no more laboratory work. Little did I know that I would return to St Mary’s Campus’ laboratories to assist in the effort to combat the COVID-19 pandemic!
I joined the College’s in-house SARS-Cov-2 testing team in October 2020 – the day after my results day (which went well!). There are a number of steps to the testing workflow that definitely seemed overwhelming at first, but after more than two months in it is all pretty much second nature. (more…)
NHLI researchers Róisín Mongey and Dr Sally Kim provide an insight into developing a new tool – the AIR model – for lung research and drug development.
Lung diseases represent a significant global health burden costing the NHS upwards of £1 billion annually. A hallmark of chronic and acute adult lung diseases such as Chronic Obstructive Pulmonary Disease (COPD), Idiopathic Pulmonary Fibrosis (IPF) and COVID-19, is lung damage. The lungs are usually capable of repairing damage but in some cases, this does not happen or the repair process goes awry for example going into overdrive and causing more damage. The result of this lack of repair or abnormal repair is persistent tissue damage and declining lung function.
There are almost no treatments available to repair the lung damage in these diseases. A bold, new approach to identify novel lung repair treatments for these diseases is needed. Unfortunately, there are several roadblocks to the development of curative treatments, the primary one being that we don’t fully understand how repair happens in the healthy lung under normal circumstances. The bottom line is that unless we can figure this out, it is unlikely that we will be able to develop successful new repair treatments. (more…)