Dr John Tregoning, Professor in Vaccine Immunology, recounts his experience of working with Dr Katalin Karikó, Nobel Prize winner and the tenacious force behind the mRNA vaccines that helped change the course of the COVID-19 pandemic. Their recently published study investigates how RNA modifications impact the body’s immune response to infection, with the hopes of aiding the development of more effective mRNA vaccines.
In the middle of the pandemic, scientists intentionally infected healthy volunteers with SARS-CoV-2, the virus that causes COVID-19. John Tregoning, Reader in Respiratory Infections at the Department of Infectious Disease, explains why these experiments, and the volunteers who take part in them, are critical to modern medicine.
In early March 2021, in the middle of the COVID-19 pandemic, a surprising-sounding set of experiments were taking place. Researchers at Imperial College London (and separately at the University of Oxford) were deliberately infecting healthy volunteers with SARS-CoV-2. This was in fact the latest in a long line of controlled human infection studies – where volunteers are deliberately infected with an infectious pathogen under extremely controlled conditions.
Dr John Tregoning (JT) from Imperial’s Department of Infectious Disease spoke to the School of Public Health’s Prof Steven Riley (SR) about the coronavirus outbreak that recently began in Wuhan, China.
Who has been working on the outbreak epidemiology at Imperial College London?
SR: It is a viral infection that was first discovered in the Chinese city of Wuhan in 2019 that has been associated with a number of cases of pneumonia – an infection of the tissue in the lungs. You might see it being called ‘2019-nCoV’, which stand for novel (or new) coronavirus. More information has been provided by the World Health Organisation. (more…)
Marking 20 years since Dr John Tregoning arrived at Imperial College London as a PhD student, he reflects on what he’s learnt over his career to date.
On 1 October 1999, I walked out of South Kensington tube station, fresh-faced and ready to start my PhD. 20 years later as I walk out of the same tube station to the same campus of the same university (still fresh-faced I like to think), the question is, have I learnt anything?
Spoiler alert – the answer is yes, but a guarded yes, from a staggeringly low starting point, like Marianas Trench low. Some of what I have learned is fairly niche and only useful if you work in a biomedical lab – like how to open a tightly screwed plastic tube with one hand whilst avoiding infecting yourself with influenza, some are a bit more generally applicable to having a career in science, especially if you are or want to run your own research group, and some grandiosely I think might be applicable to everyone.
Working in a university, this may be a bit unnecessary to point out, but education never ends: we are continually learning and evolving. Even if you were able to recall all the facts from school into adulthood it is likely that they are now either outdated or completely irrelevant to the work you do. We need to retrain: to become parents, to become managers, to change roles, to retire gracefully. And for these new roles, there is no pass/fail test to say how well you have done, it is all a bit woolly. So we need effective strategies to learn for life: both for ourselves and for the others – students, children, co-workers – that we might need to train. (more…)
Dr John Tregoning takes us on a tour of vaccination’s greatest successes, explaining how this incredible human achievement works to keep us all safer from disease – as long as we keep vaccinating ourselves and our families.
Nature wants you dead. Not just you, but your children and unborn children and everyone you have ever met.
It wants you to cough and sneeze and poop yourself into an early grave. If it can, it wants you your blood vessels to burst and pustules to explode all over your body. Put simply, Nature is trying to kill you.
And until relatively recently, it was really good at doing this. The average life expectancy of a human in 1900 was 31 years. I should already be dead.
But then science intervened with two critical innovations, clean water and vaccines, and changed everything. Clean water has had the biggest impact, but vaccines are a close second. (more…)
Dr John Tregoning explains how the use of animals in science is properly regulated and why it’s so important to respiratory research, which could impact millions of lives.
Respiratory infection is one of the main causes of disease and death throughout the world, claiming 3 million deaths worldwide in 2016. The symptoms range from the mild (a runny nose) to the extremely serious (pneumonia, hospitalisation and respiratory failure). These infections have a large economic burden both directly in medical costs and indirectly in working days lost. They also represent a potential risk for causing major pandemics; one hundred years ago the 1918 flu outbreak led to the death of 50-100 million people, significantly more than the whole First World War. There is a clear need to understand why we get sick after respiratory infections and critically we need new drugs to reduce the burden of disease. For example, there is an urgent need for a new influenza vaccine that could prevent future pandemics. (more…)
Dr (John) Tregoning and Dr (Charlie) Tregoning discuss roadblocks and solutions to equality in childcare.
We have as a couple, tried and sometimes succeeded but most often failed to share parenting fairly. Drawing from our own experience and a very shallow skim read of how to books, here are what we consider to be some of the major problems to equality at home as two working parents and some possible solutions. This is not to say every parent should go back to work; do what is best for your own family, but remember to be honest with yourself about what you really want and include yourself in the ‘what is best for my family’ calculation. (more…)