Dr Francesca Conway takes us through a typical week as a clinical research fellow and how her previous time at Imperial contributed to her developing an interest in a career in clinical academia.
6am. I’m awakened by the horrifically jolly alarm tone on my phone. It’s still dark, it’s still raining, and it’s still cold. Hedgehogs have the right idea hibernating over winter, I think, as I haul myself out of bed. Must consider this hibernation proposition in my next supervisor meeting. 1 shower, 1 yoghurt and 3 smoothies later and I’m in the hospital.
Today I have a patient coming to see if she is eligible to be recruited to the clinical trial which forms part of my PhD. Mrs X has travelled from 300 miles away. She greets me with a smile and tells me how pleased she is to be here. I immediately remember why I love my job, and scrap the idea of hibernation. I offer her a coffee, she gratefully accepts and whispers, could I have an extra shot in that? I assume she means coffee. I wonder what time she woke up, but am pretty sure it was before 6am.
I am researching a potential new treatment for Chronic Cbstructive Pulmonary Disease (COPD) for my PhD. Mrs X suffers with COPD, a disease affecting the lungs most commonly caused by smoking. More than 3 million people die from it each year. Targeted Lung Denervation or “TLD”, is a non-surgical procedure where we deliver energy to the airways using a system made by Nuvaira, a US-based company. The idea is that the energy disrupts the nerve supply to the lungs, so the airways relax and open. With initial data looking promising, we hope that this will lead to improvements in health for patients like Mrs X. More information on the Airflow website. (more…)
As Lauren Headley-Morris nears the end of her PhD, she reflects on the experience gained and why learning won’t stop after she’s completed her terminal degree.
Terminal is a weird word. Usually heard on TV associated with cancer, you wouldn’t necessarily want a degree that is terminal. Some days I think my PhD is the best thing since the sequencing of the human genome; other days I think it might be the death of my love of science. But terminal is used in some less, erm, disastrous, melodramatic? scary? ways.
One of these less-morbid settings is travel. A PhD is, by nature, the end of the line of academic qualifications. It doesn’t mean you’ve now mastered your subject, sadly. There are post-doc positions and even professorships in the future perhaps.
I’m a third-year, Asthma UK funded, Clinical Medical Research PhD student based at the Guy Scadding Building, Royal Brompton campus. My work is focused on transcriptional regulation in asthma. While my day to day is obsessing about microRNA and things that are too tiny to see, I think it’s important to take a second now and then to sit back and reflect on the bigger picture of where my PhD fits in with my life as a whole. Maybe it’s the effect of spending so much time in isolation or maybe, coming to the end of my formal academic training, I’m getting a little philosophical. (more…)
NHLI researchers Róisín Mongey and Dr Sally Kim provide an insight into developing a new tool – the AIR model – for lung research and drug development.
Lung diseases represent a significant global health burden costing the NHS upwards of £1 billion annually. A hallmark of chronic and acute adult lung diseases such as Chronic Obstructive Pulmonary Disease (COPD), Idiopathic Pulmonary Fibrosis (IPF) and COVID-19, is lung damage. The lungs are usually capable of repairing damage but in some cases, this does not happen or the repair process goes awry for example going into overdrive and causing more damage. The result of this lack of repair or abnormal repair is persistent tissue damage and declining lung function.
There are almost no treatments available to repair the lung damage in these diseases. A bold, new approach to identify novel lung repair treatments for these diseases is needed. Unfortunately, there are several roadblocks to the development of curative treatments, the primary one being that we don’t fully understand how repair happens in the healthy lung under normal circumstances. The bottom line is that unless we can figure this out, it is unlikely that we will be able to develop successful new repair treatments. (more…)
Westminster Medical School – one of the schools that formed Imperial College School of Medicine – has been home to many pioneers. But few can claim a connection to royalty.
Sir Clement Price Thomas, student and surgeon at Westminster and one of the fathers of thoracic surgery, rose to fame after an operation on King George VI. Read on to learn just how challenging this procedure would have been.
The reign of George VI was a turbulent time for the monarchy. At the end of a brutal world war and the dissolution of the largest empire the world has ever seen, the King’s health took a turn for the worse.
Because of the King’s chest problems, Sir John Weir, the Royal Family’s doctor, called in a lung disease expert, Geoffrey Marshall, and chest expert, Sir Robert Arthur Young. After X-rays and a bronchoscopy revealed a malignant tumour in his left lung, the King’s physicians set to work organising a secret operation. They all agreed that Clement Price Thomas was the best surgeon for the job.
Setting up the makeshift theatre
The operation was planned for 22 September 1951 at Buckingham Palace. But the Buhl room clearly wasn’t designed for major surgery, despite the equipment brought in for the occasion. With the stakes so high, Price Thomas demanded that the palace install emergency lighting in the room. The palace agreed – and even moved the changing of the guard to St James’s Palace to make sure the surgical team were not disturbed by the noise outside.
On Sunday 23 September 1951, the room was ready and Price Thomas, his two surgical registrars and his scrub team set to work. (more…)
Australia was the first country in the world to introduce standardised, or plain, packaging for cigarettes and tobacco. The move was the product of a long-running campaign from the public health community and meant that the packets are allowed no branding; just the product name in standard font, colour and size. Since Australia brought in these measures, the UK followed in 2017, as did Ireland and France, increasing the number of countries in the world which restrict one of the key avenues for the tobacco industry to advertise their products. (more…)
This is an open letter from Mr Martin Lupton, Vice-Dean of Education to taught students in the Faculty of Medicine and their loved-ones.
Dear Students and their friends and families,
My eldest son has recently returned to University in the UK and, even though I work in both the health and education sector, I have to acknowledge that I have a certain level of anxiety about him. It is very difficult to read the news about all that has happened during this time of COVID and not to worry.
I am telling you this because I want you to understand that I have some inkling of what you may be feeling right now, particularly if you come from overseas or your daughter, son or relation, has just started their university life. The first thing I want to say is “Welcome to the Faculty of Medicine”. We are very proud of what we have achieved during this global pandemic; the Faculty of Medicine at Imperial College has been a key player contributing to the world’s understanding of the virus, the mapping of the virus, teaching people about the virus and developing a new vaccine. However, that is not all that we have been doing. (more…)
As the global COVID-19 pandemic draws on, effects are being felt by everyone, not just those who have been infected with the virus. From schools to offices, restaurants to gyms, many aspects of ‘normal’ have been closed, stopped, or undergone major adaptations. These societal and healthcare disruptions will affect people differently, with certain groups of people, such as those with respiratory conditions, potentially more vulnerable.
Over the last few months I have been working with Dr Nicholas Hopkinson (Respiratory Consultant, NHLI Academic, and Medical Director of the British Lung Foundation(BLF)), Dr Bradley Lonergan (Internal Medicine Trainee) in collaboration with the Asthma UK-BLF partnership, to try to understand how people with long term respiratory conditions have been impacted by measures to reduce the risk of COVID-19.
Our research published today in BMJ Open explores the findings of a large UK wide survey conducted at the height of the first wave. We found that measures to reduce risk of COVID-19, such as social distancing and changes to healthcare provision, were having profound impacts on people with long term respiratory conditions. These included cancellations of appointments, investigations, and vital aspects of their care such as pulmonary rehabilitation. (more…)
Our BSc in Remote Medicine for intercalating medical students focuses on exploring medicine in remote and low-resource environments.
Normally students would have an opportunity to travel to the Nepali Himalayas to carry out a research project. With the expedition cancelled due to Covid-19, four remote medicine students discuss how they adapted their research projects.
For my original research project, I chose to investigate sleep during an expedition to high altitude. Previous research has shown that human error is the leading cause of mountaineering accidents and at sea-level, sleep deprivation increases the risk of accidents due to human error. Therefore, my aim was to determine the contribution of the mountaineering environment to poor sleep and impaired cognitive performance on an expedition to altitude – using a reaction time application as a surrogate marker for cognitive function. Unfortunately, due to COVID-19 the planned expedition to Nepal was cancelled and so I devised a pilot study to test the reaction time application I wanted to use at altitude remotely with a small group of participants simulating a night slept at altitude in their own homes. (more…)
Three medical students reflect on how they navigated and completed their intercalated BSc research projects remotely amid the pandemic.
Ioannis Panselinas, BSc Translational Respiratory Medicine
Had someone told me back at the start of 2020 what the year would have in store, I would have probably said that they had stolen ideas from an Orwellian dystopia. Yet the world is currently in the grips of one of the most terrible pandemics in living memory. And among all the global disruption were us 4th year Imperial medics having to face a transition to remote working in the middle of project period. Unsurprisingly, lab work cannot be done from the comfort of our homes. So, as COVID-19 hit the UK, we were forced to cut short our experiments and were ultimately left with a looming deadline and a project to complete. In retrospect, I think I can sum up my experience with the 5 stages of COVID disruption:
Originally published in The Biochemist, Karim Boustani and Kirk Taylor discuss their experiences of being LGBTQ+ in bioscience, the various types of discrimination that LGBTQ+ scientists may face in academia and some of the existing initiatives and campaigns in place to combat this.
Before we get into the nitty-gritty of this article, we want to make clear that this piece is written from the perspective of two cis gay men and anyone reading this should realize that our experiences are not universal. Everyone within the community has a different journey and we cannot speak about anyone else’s experience.
We would also like to define a few terms that will be used throughout the article to help you understand the points that we make, although we would like to stress that, in this area, definitions are contested (Table 1). We use the term LGBTQ+ to refer to anyone who identifies as lesbian, gay, bisexual, trans or intersex, or anyone who is sexually and/or gender diverse. Sexual orientation refers to whom people are attracted to and form romantic or sexual relationships with. This can be to people of the opposite sex or gender (heterosexual), same sex or gender (homosexual), both sexes or genders (bisexual), more than one sex or gender (pansexual) or lack of sexual attraction to any sex or gender (asexual). Gender identity refers to how we subjectively perceive our gender, which may or may not correspond with the sex we are assigned with at birth. Society has created a gender binary, which includes expectations of masculinity and femininity, which is applied to sex, gender identity and gender expression (i.e. the way you express your gender through clothes, hair or makeup). It is important to note that some people do not identify with this binary (e.g. non-binary individuals) and some people do not identify with some or all aspects of the gender assigned to them. As scientists, we must also recognize that our choice of indicators for biological sex categorizations are unstable (on this topic, we would encourage all to read Professor Anne Fausto-Sterling’s “Science Won’t Settle Trans Rights”). Transgender (or trans) refers to individuals whose gender identity and/or gender expression differs from the expectations of the gender they were assigned at birth. Being trans is not associated with a person’s sexual orientation. Those who do not identify as trans are described as cisgender. LGBTQ+ discrimination may be based on sexual orientation, gender identity, gender expression or sex characteristics. (more…)