Recognising the value of interdisciplinary learning, Imperial’s Food Student Research Network aims to bring together students from across the College’s faculties to enable the cross-fertilisation of ideas and research in fields relevant to food. Here, members reflect on the Network’s inaugural conference.
In September, Imperial’s Food Student Research Network hosted its first Annual Conference. Reflective of the ethos of the network, this conference was an event for students, led by students.
Providing the most comprehensive picture of COVID-19 infectiousness to date, recent research from Imperial College scientists offered new insights into how long people with COVID-19 are infectious for. Co-author, Dr Seran Hakki, outlines the challenges of collecting real-world evidence in the first-of-its-kind study.
In August, the ATACCC Study (The Assessment of Transmission and Contagiousness of COVID-19 in Contacts) published some of their findings in one of the world’s leading respiratory health journals, The Lancet Respiratory Medicine. Our study was the first to use real-life evidence from naturally acquired infection to assess the duration of COVID-19 infectiousness, its correlation with symptom onset, and how this affects the accuracy of lateral flow tests.
In the middle of the pandemic, scientists intentionally infected healthy volunteers with SARS-CoV-2, the virus that causes COVID-19. John Tregoning, Reader in Respiratory Infections at the Department of Infectious Disease, explains why these experiments, and the volunteers who take part in them, are critical to modern medicine.
In early March 2021, in the middle of the COVID-19 pandemic, a surprising-sounding set of experiments were taking place. Researchers at Imperial College London (and separately at the University of Oxford) were deliberately infecting healthy volunteers with SARS-CoV-2. This was in fact the latest in a long line of controlled human infection studies – where volunteers are deliberately infected with an infectious pathogen under extremely controlled conditions.
The government is on course to miss its target of making England smoke free by 2030. Dr Charlotte Vrinten, Research Associate at the School of Public Health, highlights how this delay leads to thousands of adolescents taking up the habit in the meantime.
Tobacco smoking has been declining in the UK over the last decade, but there are still nearly 7 million people who smoke. Smoking is one of the main avoidable causes of illness and early death, and costs the NHS £2.4 billion per year. In 2019, the government pledged to make England smokefree by 2030. However, a recent independent review found that the government is on course to miss its 2030 target by seven years. (more…)
Finding the right PhD programme can often be a time-consuming and lengthy exercise. Emre Yavuz, Translational Neuroscience Master’s student, shares his experience of applying for a PhD programme and the many challenges he faced along the way.
This September I’m going to be starting my PhD in Cognitive Neuroscience at UCL, supervised by Professor Hugo Spiers. Excited as I am about moving onto the next chapter of my career, choosing the right PhD for me was no easy process.
Choosing the right PhD programme comes down to many variables. When I had initially applied for several programmes in early December, I was excited by the possibility of travelling and living abroad after two years of lockdown. I had received interviews from places including Toronto, Montreal, Zurich, Lausanne and London. Although studying abroad seemed highly tempting at first, there were many other factors I had to take into account. (more…)
Following the publication of new draft guidance by NICE on the care and management of osteoarthritis, Dr Fiona Watt breaks down the misconceptions surrounding its impact on patients and healthcare professionals, and why developing effective treatments for the condition is more vital than ever.
8.75 million people live with osteoarthritis in the UK and the condition is the fourth leading cause of years lived with disability worldwide. Osteoarthritis commonly affects joints such as the knee, hip or hand, leading to progressive change and damage in joint tissues, frequently causing joint pain and functional difficulties. It is the leading cause of joint replacement. As an osteoarthritis researcher and someone who treats people with osteoarthritis in the NHS, I awaited the draft updated National Institute for Health & Care Excellence (NICE) guidance on the management of osteoarthritis with some anticipation. This guidance is important because it shapes (and restricts) the way that the NHS approaches advice and treatment, based on scientific evidence.
For Dementia Action Week, Kitty Murphy, second year PhD student at the UK DRI Centre at Imperial, shares the complex nature of Alzheimer’s disease and why there’s more to it than just our genes.
Dementia diagnosis rates are dropping for the first time ever. I wish I could tell you that this is due to less people developing dementia, and not because more people are living with it undiagnosed. According to research carried out by Alzheimer’s Society, many people are not being diagnosed due to the misconception that memory loss is a normal part of aging. However, memory loss is often an early sign of dementia, particularly in the most common cause known as Alzheimer’s disease. As a result, the Alzheimer’s Society’s Dementia Action Week, an annual awareness campaign, has made diagnosis their featured theme.
Dr Emma Smith—HIC-Vac Network Manager—explains how specific guidelines for the provenance and manufacture of challenge agents could make human infection studies even safer.
Human infection studies, also known as human challenge studies, are clinical trials where volunteers are intentionally given a carefully considered dose of a pathogen—known as the challenge agent. These models can be used to study host-pathogen interactions and disease progression; identify and test the efficacy of promising vaccines and drugs in development; or be used as proof-of-concept studies for testing novel medications. In this controlled environment it is possible to study infections in ways that aren’t possible in traditional field studies.
One of the first steps towards establishing a challenge study is the selection, isolation, development and production of the challenge agent. However, unlike medicines, the regulation of challenge agent manufacture varies internationally; an area that the research community has identified as a potential weakness in the field. Although human challenge studies have an excellent safety record—a recent literature review identified just 24 Serious Adverse Events (SAE) and zero deaths or cases of permanent damage among 15,046 participants in 308 studies spanning 1980 to 2021— the lack of specific guidelines for the provenance and manufacture of challenge agents warrants attention.
HIC-Vac—an Imperial-led international network of researchers who are developing human infection challenge studies—has been working with the global charitable foundation Wellcome and the company hVIVO to address this unmet need. Our purpose was to promote volunteer safety whilst maximizing access to challenge agents and challenge models globally. (more…)
Matthew Harrison provides an insight into the world of human centred design, highlighting how involving users early in the design process can allow us to tap into their expertise and find creative solutions.
COVID has changed many aspects of life permanently. One change is the way we have and will interact with healthcare services. It has put the path to remote and smart care on an accelerated trajectory. Virtual consultations, at home diagnostics, and remote sensors, tablet computers and smart speakers are increasingly part of our lives. But the rush to technology in healthcare risks leaving the demographic who most need it behind. This is a prime example of where Human Centred Design (HCD) comes in. Design is about optimising the relationships between humans and technology, whether it is the clarity of a printed communication, the impact of a building on well-being, the confidence you feel from a new outfit, or the usability (and safety) of an Electronic Patient Record.
Are loneliness and social isolation the bane of living in the 21st Century? Since the early days of 2020, national lockdowns, social distancing measures and remote working have put a bright spotlight on loneliness – one of society’s rising problems that governments can no longer overlook. Dr Austen El-Osta shares how his new project to map loneliness in London hopes to highlight the scale of the issue.
The UK Government published the first Loneliness Strategy in 2018 and has since installed a Loneliness Minister to get people talking about the problem. This cross‑governmental strategy has three goals:
Loneliness and social isolation are significant determinants of health and quality of life. They are strongly associated with psychological disorders, cardiovascular disease and are even a risk factor for the exacerbation of early mortality. For the last few decades, increasing urbanisation and over-reliance on technology has led to the ‘atomisation’ of society – think online games, virtual reality, chat rooms, AI chatbots and the recently publicised Metaverse. There is also an increasing number of services which can be accessed online including shopping and healthcare which decreases the need, and opportunity, for “in person” encounters.