Search Results for: heart disease

Inspirational leadership matters: supporting the next generation of clinical academics

Dr Maddalena Ardissino

This festive period, Three Wise Women from the Faculty of Medicine will be giving us the gift of wisdom.

The journey to becoming a clinical academic can be long and arduous, with many obstacles. Dr Maddalena Ardissino, from the National Heart and Lung Institute, reflects on her own experiences as a trainee and explains why mentorship is key to supporting the growth and development of young, aspiring clinical academics.

Almost exactly five years ago, I stood amongst a crowd of young academics at a poster session at the Intensive Care Society’s annual conference, experiencing a feeling of anxiety I’ve never known before or since. I was in my fifth year of medical school and standing in front of a group of excellent researchers who were about to listen to me give my first scientific presentation. It seemed unthinkable to me, at the time, to think that they might have the slightest interest in what I had to say.

Since then, my journey through clinical and academic training has been what I can only describe as an adventure. I quickly realised that there isn’t a single defined path for clinical academics, with each individual moulding a slightly different journey. When I look around at my fellow clinical academics at the National Heart and Lung Institute, however, there is one key feature that we all share: enthusiasm. And behind this feature there is one single, common theme: the support of a truly inspirational mentor.

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Empowering women through the Elevat(Her) Podcast

PhD students Salina Nicoleau & Maike Haensel outline their vision for The Elevat(Her) Podcast and share the importance of highlighting positive female role models to empower other women to achieve their full potential.

Look around you – how many women are in senior positions across your university? Lucky you if you can count more than a couple. According to a recent report by the Higher Education Statistics Agency (HESA), women account for only 28% of professors in UK universities in 2020/21 (1). This is a recurring theme within many sectors, not just higher education, where there are fewer women than men in senior positions. In 2021, the number of female Fortune 500 CEOs was only 41. Yes, out of 500 CEOs, 459 were men (2).

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The trials and tribulations of applying for a PhD

Finding the right PhD programme can often be a time-consuming and lengthy exercise. Emre Yavuz, Translational Neuroscience Master’s student, shares his experience of applying for a PhD programme and the many challenges he faced along the way.

This September I’m going to be starting my PhD in Cognitive Neuroscience at UCL, supervised by Professor Hugo Spiers. Excited as I am about moving onto the next chapter of my career, choosing the right PhD for me was no easy process.

Choosing the right PhD programme comes down to many variables. When I had initially applied for several programmes in early December, I was excited by the possibility of travelling and living abroad after two years of lockdown. I had received interviews from places including Toronto, Montreal, Zurich, Lausanne and London. Although studying abroad seemed highly tempting at first, there were many other factors I had to take into account. (more…)

Standing up for the facts: COVID-19 vaccination, fertility and pregnancy

This festive period Three Wise Women from the Faculty of Medicine will be giving us the gift of wisdom.

Dr Viki Male explains how she took matters into her own hands in response to the mixed messaging around COVID-19 vaccination advice and pregnancy.

In 2003, the world was on the brink of a SARS-1 pandemic. As a Year 12 student at the time, I followed developments closely. Although the outbreak eventually died out, my interest in infectious diseases did not. Surely, the big one was coming. And I would be ready for it.

But by the time the big one came, my research has taken me in a different direction. At university, I had become passionately interested in a family of immune cells, called NK cells, that control viral infection. But these cells have another role that captured my imagination: they help the placenta to implant during pregnancy, and my lab is working out how. In March 2020, as immunologists around the world raced to make a vaccine, I shut my lab and went home to spend the next 12 weeks home-schooling my children. I would sit this one out. What use is a reproductive immunologist in a pandemic, anyway?

Some use, it turned out. In December 2020, as the vaccine rollout began, rumours started to circulate that antibodies raised by COVID-19 vaccination would target a placental protein, called Syncytin-1, causing infertility and miscarriages. There was no basis to this claim and if I, a reproductive immunologist, wouldn’t stand up and explain why, then what was the point of me? So I began engaging with the public, first on social media and then in print and broadcast. Here’s what they taught me… (more…)

We need to give everyone, everywhere, the precious gift of health

Professor Faith Osier

This festive period Three Wise Women from the Faculty of Medicine will be giving us the gift of wisdom.

Professor Faith Osier shares her vision for health equity, from tackling vaccine inequity to empowering the next generation of scientists globally.

Almost a year ago to the day, my partner and I woke up our three young children in the middle of the night, readied them for the airport, hurriedly scrambled together the last of our belongings and embarked on a new adventure. We were moving from Heidelberg, a picture-perfect city that often made me feel like I was walking into a tranquil postcard. This had been home for four years and we kept our mixed feelings to ourselves as we ventured into the unknown, London. I was taking up a new position as the Executive Director of IAVI (formerly International AIDS Vaccine Initiative), at Imperial College London. We navigated the intricacies of relocating during lockdown, settled the children into school or rather “joyous home-learning” as was the case at the time, and I began to unpack my new job.

The mission of IAVI resonates strongly within me: “translating science into affordable, globally accessible public health solutions”. The opportunity to turn years of scientific endeavour into interventions that could transform the lives of the most vulnerable on our planet still springs me out of bed every day.  I have worked for over 25 years amongst the rural poor in Kilifi, Kenya, studied immune responses to malaria antigens in samples from similar study participants across Africa and appreciated first-hand the impact of ill-health on productivity, livelihoods and hope. (more…)

Future of Nutrition: Student experiences from the Nutrition Futures Conference 2021

The Imperial Conference committee with The Nutrition Society Student Committee Leads.
The Imperial Conference committee with The Nutrition Society Student Committee Leads.

Three Imperial postgraduate research students recount their experiences of hosting the Nutrition Futures Conference 2021 in collaboration with The Nutrition Society.

In September 2021, Imperial’s Section of Nutrition Research hosted the Nutrition Futures Conference 2021 in collaboration with The Nutrition Society at the Cavendish Conference Centre, Marylebone.

The Nutrition Society is one of the largest learned societies for nutrition in the world. In late 2019, Dr Aaron Lett led the bid to bring this student-focused conference of the Nutrition Society’s conference calendar to Imperial College London. This was the first conference the Section of Nutrition Research at Imperial has hosted and provided the perfect opportunity for Imperial to share its expertise in nutrition-related research and strong ethos and enthusiasm for student development to undergraduate and postgraduate nutrition students across the world. (more…)

From bench to bedside and back again in mesothelioma

On Mesothelioma Awareness Day, Dr Anca Nastase provides an insight into mesothelioma and how research advances offer new hope for improved treatment.

Mesothelioma Awareness Day represents a great opportunity to gain more information about the disease biology, risk factors or symptoms from everyone in the mesothelioma community. Raising awareness is essential as it has the potential to improve prevention and early diagnosis and can translate into better outcomes and better survival for the patients.

My aim as a scientist within the National Centre for Mesothelioma Research (NCMR) is to deepen the molecular research in mesothelioma and to advance our understanding of the mechanisms responsible for the onset and progression of this disease.

Although progress has been made in the field, further understanding of the pathophysiology is still desperately needed.

Mesothelioma is a type of cancer that arises and develops in the thin layer that covers the human internal organs, called mesothelium.

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COVID and lung health: patient experience and what comes next?

The pandemic has been a huge challenge for people with lung disease – Dr Nick Hopkinson outlines what needs to change to provide them with the required support.

The COVID-19 pandemic has had a double impact on people with lung disease – both the impact of the condition itself as well as measures to avoid it on individuals and the impact on access to healthcare. COVID-19 is a respiratory infection, with people with COPD and severe asthma among those who are the most vulnerable. Many people with these conditions have spent a year shielding to avoid it.

Data from patient surveys by the Asthma UK and British Lung Foundation Partnership early in the pandemic found high levels of anxiety, with four key themes emerging from survey responses:

  • Individuals’ vulnerability to COVID-19,
  • Worrying what the experience of contracting COVID-19 would be like,
  • Uncertainty about the future,
  • The inadequacy of government response.

Many patients reported that their care had been disrupted, with reduced support available and face to face appointments replaced by remote options. (more…)

A week in the life of a Clinical Research Fellow

Dr Francesca Conway takes us through a typical week as a clinical research fellow and how her previous time at Imperial contributed to her developing an interest in a career in clinical academia.

Monday

6am. I’m awakened by the horrifically jolly alarm tone on my phone. It’s still dark, it’s still raining, and it’s still cold. Hedgehogs have the right idea hibernating over winter, I think, as I haul myself out of bed.  Must consider this hibernation proposition in my next supervisor meeting. 1 shower, 1 yoghurt and 3 smoothies later and I’m in the hospital.

Today I have a patient coming to see if she is eligible to be recruited to the clinical trial which forms part of my PhD. Mrs X has travelled from 300 miles away. She greets me with a smile and tells me how pleased she is to be here. I immediately remember why I love my job, and scrap the idea of hibernation. I offer her a coffee, she gratefully accepts and whispers, could I have an extra shot in that? I assume she means coffee. I wonder what time she woke up, but am pretty sure it was before 6am.

I am researching a potential new treatment for Chronic Cbstructive Pulmonary Disease (COPD) for my PhD. Mrs X suffers with COPD, a disease affecting the lungs most commonly caused by smoking. More than 3 million people die from it each year. Targeted Lung Denervation or “TLD”, is a non-surgical procedure where we deliver energy to the airways using a system made by Nuvaira, a US-based company. The idea is that the energy disrupts the nerve supply to the lungs, so the airways relax and open. With initial data looking promising, we hope that this will lead to improvements in health for patients like Mrs X. More information on the Airflow website. (more…)

A breath of fresh ‘AIR’ in the study of lung repair and regeneration

NHLI researchers Róisín Mongey and Dr Sally Kim provide an insight into developing a new tool – the AIR model – for lung research and drug development.

Lung diseases represent a significant global health burden costing the NHS upwards of £1 billion annually. A hallmark of chronic and acute adult lung diseases such as Chronic Obstructive Pulmonary Disease (COPD), Idiopathic Pulmonary Fibrosis (IPF) and COVID-19, is lung damage. The lungs are usually capable of repairing damage but in some cases, this does not happen or the repair process goes awry for example going into overdrive and causing more damage. The result of this lack of repair or abnormal repair is persistent tissue damage and declining lung function.

There are almost no treatments available to repair the lung damage in these diseases. A bold, new approach to identify novel lung repair treatments for these diseases is needed. Unfortunately, there are several roadblocks to the development of curative treatments, the primary one being that we don’t fully understand how repair happens in the healthy lung under normal circumstances. The bottom line is that unless we can figure this out, it is unlikely that we will be able to develop successful new repair treatments. (more…)