Category: Department of Infectious Disease

Convincing my daughter that our research in malaria matters

On World Malaria Day, Dr Aubrey Cunnington’s daughter spends the day at his lab to learn how his team’s research is contributing to tackling malaria. 

25 April is a special day in my calendar this year for two reasons. First, it is World Malaria Day – a chance for malaria researchers and many others to unite to raise awareness of this dreadful disease which kills over 400,000 people every year. Second, it is “Take Your Daughter to Work Day” for my 13-year old’s school, and she has chosen to spend the day with me at Imperial College London. I’m flattered but I’m also worried, because she can be my harshest critic, and on World Malaria Day I want to convince her (and everyone else) that my research is making a difference against malaria.

So what will it take to impress my 13-year old daughter, and perhaps give her the confidence and inspiration for a career? Looking for help, I ask my research team how they would explain their work to a 13-year old. Despite worried expressions, they are all up for giving it a go. (more…)

Tackling drug resistant infection through collaborative global action

Imperial’s Dr Esmita Charani and Dr Jamal Uddin, Child Health Research Foundation (CHRF), observing field work surveillance conducted by CHRF healthcare workers in Bangladesh as part of the demographic and disease surveillance initiatives aimed at reducing childhood morbidity and mortality.

Ahead of the recent G20 Summit in Buenos Aires, Professor Alison Holmes explained in an article for G20 Magazine why global collaboration is essential to minimising the impact of antimicrobial resistance (AMR) on healthcare.

The world faces the unprecedented challenge of drug resistant infection due to increasing AMR. Concerted global action is needed to address this pressing and alarming public health issue. Without a strong, unified response, the UN’s Sustainable Development Goals (SDGs) will not be met, and valuable progress will be lost.

The need for leadership

The continued inclusion of AMR in the G20 agenda, under the leadership of Argentina, is greatly welcomed. This year I was invited to speak in Buenos Aires on initiatives to optimise antibiotic use, at the International Congress on Infectious Diseases, co-hosted by the Infectious Diseases Society of Argentina. The ethos of shared learning and strong leadership was central in our discussions, and considered fundamental to effective action. (more…)

Blood transfusion in sub-Saharan Africa: 200 years on

200 years on from the first successful human-to-human blood transfusion, this procedure has revolutionised patient care. However, there is still work to be done in sub-Saharan Africa, as Professor Kathryn Maitland explains.

Each year, around 2.5 million units of blood are transfused in the UK – that’s enough to fill two Olympic sized swimming pools! Since James Blundell performed the first successful human blood transfusion in 1818, this life-saving medical intervention has made many advances to ensure its accessed throughout the world. An important part of this is ensuring that any health system has adequate supplies of quality-assured and safe blood for transfusion through national and regional blood transfusion services (BTS). (more…)

Capturing cells’ tiny messages: the emerging importance of extracellular vesicles in medicine

In this post, Dr Richard Kelwick explores exosomes – the tiny vesicles that may hold great therapeutic potential.

The adult human body is composed of around 30 trillion cells! That’s a lot of cells, and researchers are still figuring out the remarkable processes that govern how our cells are exquisitely organised into the complex tissues, organs and systems that make up our bodies. In order for our cells to co-ordinate and organise themselves correctly they need to be able to communicate with each other at the molecular level. Cells can communicate with each other using a variety of different ways, either by physically tugging on neighbouring cells, or by secreting proteins, hormones and many other types of signalling molecules. Cells can also send exosomes to each other. (more…)

Hope for a hepatitis B cure: the cunning virus that is outsmarting scientists

For World Hepatitis Day, Dr Ana Ortega-Prieto explains why she switched her research focus from hepatitis C to hepatitis B – a virus that continues its global spread despite an available vaccine. 

When I first started to work on hepatitis C virus (HCV) for my PhD, the general conviction was that it was a dangerous pathogen with very unsuccessful treatments. In the past years, this has completely changed; patients used to endure one year of treatment with severe side effects, but can now expect just three months of treatment, which is generally well tolerated. The truly impressive part here is that treatment success went up from below 50% to well over 90%. This has triggered the World Health Organisation (WHO) to aim for the eradication of all viral hepatitis by 2030 – a very ambitious goal. (more…)

Reducing, refining and replacing the use of animals is crucial to respiratory research

Animal research

Dr John Tregoning explains how the use of animals in science is properly regulated and why it’s so important to respiratory research, which could impact millions of lives.

Respiratory infection is one of the main causes of disease and death throughout the world, claiming 3 million deaths worldwide in 2016. The symptoms range from the mild (a runny nose) to the extremely serious (pneumonia, hospitalisation and respiratory failure). These infections have a large economic burden both directly in medical costs and indirectly in working days lost. They also represent a potential risk for causing major pandemics; one hundred years ago the 1918 flu outbreak led to the death of 50-100 million people, significantly more than the whole First World War. There is a clear need to understand why we get sick after respiratory infections and critically we need new drugs to reduce the burden of disease. For example, there is an urgent need for a new influenza vaccine that could prevent future pandemics. (more…)

The truth about HTLV-1: unravelling 30 years of misconceptions

HTLV-1

As the human T-cell leukaemia virus is discussed on the world stage, Professor Graham Taylor addresses the misconceptions surrounding HTLV-1.

Based on the number of articles published in mainstream media, and the number of interview requests I have received in the last week, it seems that everyone wants to know about HTLV-1, the human T-cell leukaemia virus, after 30 years of turning a blind eye. Why the sudden interest in a virus that few outside my field of human retrovirology have heard of? (more…)

Working together, protected together: addressing the challenges of vaccine research

Working together, protected together: addressing the challenges of vaccines researchAs the Imperial Network for Vaccine Research launches, Dr Chris Chiu tells us why he’s in pursuit of a collaborative approach for developing new vaccines. 

Vaccines have been very much in the public eye for a while now, with strong feelings expressed particularly on the side of those who are suspicious of them. As health and scientific professionals, we often try to provide a carefully balanced view but, in this case, it is vitally important that we remember and highlight the massive amount of good that vaccines have done for human health. Once devastating diseases such as smallpox and polio are now gone or almost gone. Vaccines have truly been one of the great triumphs of modern medicine. (more…)

Encephalitis: the rare disease with a million implications

 

22 February is World Encephalitis Day. Founded by The Encephalitis Society four years ago, it aims to help raise awareness of the disease on an international scale.

In a nutshell, encephalitis refers to the inflammation of the brain. Up until recently, it was thought that encephalitis was simply either a viral or bacterial infection. However, in 2005, research described a new version of the disease: auto-immune or ‘anti-NMDAR encephalitis’, which is caused by antibodies that attack the brain tissue. In all its forms, encephalitis is incredibly rare: herpes simplex encephalitis (HSE), for instance, affects approximately one in 1,000,000 children. Although there are clear treatment routes available, viral encephalitis is incredibly destructive. The virus can cause irreversible damage in the brain, which will continue to impact upon a patient’s quality of life well after their short-term recovery from the disease itself. (more…)

Leprosy in 2018: an ancient disease that remains a public health problem today

World Leprosy Day. Image courtest of Wellcome Collection.

For World Leprosy Day 2018,  Dr Tim Rawson explores how leprosy is not quite yet a disease of the past.

I have always found leprosy a fascinating disease. It is an incredible example of how microbiology, immunology, and social sciences can collide and impact significantly on human health.

Leprosy has been affecting humans for at least 4000 years. It has played a huge part in teaching us about disease caused by bacteria. In 1873 when Hansen discovered Mycobacterium leprae in tissue samples from patients with leprosy, this became the first bacteria to be directly linked to causing disease in humans. Since then we have developed an understanding of the complex range of types of leprosy that occur depending on how an individual’s immune system responds to the challenge of infection with Mycobacterium leprae. We have also observed the consequences of the deformities and disability caused by the body responding to Mycobacterium leprae, which favours human nerves and skin. In turn, we have seen how the appearance of individuals with disability and disfigurement from leprosy has driven stigma, misinformation, and the discrimination of those affected by the disease. (more…)