Blog posts

Can we save lives by deliberately infecting people?

A person's arm being injected

In the middle of the pandemic, scientists intentionally infected healthy volunteers with SARS-CoV-2, the virus that causes COVID-19. John Tregoning, Reader in Respiratory Infections at the Department of Infectious Disease, explains why these experiments, and the volunteers who take part in them, are critical to modern medicine.

In early March 2021, in the middle of the COVID-19 pandemic, a surprising-sounding set of experiments were taking place. Researchers at Imperial College London (and separately at the University of Oxford) were deliberately infecting healthy volunteers with SARS-CoV-2. This was in fact the latest in a long line of controlled human infection studies – where volunteers are deliberately infected with an infectious pathogen under extremely controlled conditions.

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The future of smoking: why are young people still picking up the habit?

two hands snapping a cigeratte in half

The government is on course to miss its target of making England smoke free by 2030. Dr Charlotte Vrinten, Research Associate at the School of Public Health, highlights how this delay leads to thousands of adolescents taking up the habit in the meantime.

Tobacco smoking has been declining in the UK over the last decade, but there are still nearly 7 million people who smoke.  Smoking is one of the main avoidable causes of illness and early death, and costs the NHS £2.4 billion per year. In 2019, the government pledged to make England smokefree by 2030.  However, a recent independent review found that the government is on course to miss its 2030 target by seven years. (more…)

Medicine in the Mountains

In March 2022, a group of medical students undertook a research expedition to the Atlas Mountains in Morocco. Georgia Leggett, reflects on her experience summiting Mount Toubkal and the challenges that come with conducting research in such a remote environment.

Before starting at Imperial, I was fortunate enough to co-lead a couple of charity projects in Brazil, where my varied experiences sparked my interest in health care provision in remote and extreme environments. Applying for the Remote Medicine BSc was an obvious choice, as it provided the opportunity to integrate my love of travel and adventure into my medical degree, and in March 2022, seven other students and I had the opportunity to carry out a research expedition to the Atlas Mountains in Morocco as part of our BSc projects.

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Consulting and involving the public in the first human COVID-19 human challenge study

How do you engage members of the public with medical research? Dr Emma Smith, HIC-Vac Network Manager, outlines how consulting the public was crucial during the world’s first COVID-19 human challenge study.

It is important that health and social care research aims to improve the overall well-being of the population, from advancing treatments for patients to helping us live healthier lives. People are at the heart of medical research and so engaging and involving them is an integral part of the research process and one that is mandated by most funders.

When we set up the world’s first COVID-19 human challenge study, acceptability of research to participants and society more broadly was particularly relevant because of the study’s ethically complex nature.

With volunteer participants being deliberately exposed to coronavirus (COVID-19) and the associated risk (albeit very small) of serious illness or death, the public’s perspectives were an important element of assessing if the study was acceptable and ethical (and was stated by the WHO1  as one of the key criteria for the ethical acceptability of COVID-19 human challenge). (more…)

Don’t let a fear of the unknown limit your ambitions – my experience of studying for a Master of Public Health during the pandemic

Graduating is a significant milestone, especially if your studies have been impacted by Covid-19.  Jasmin Adebisi, now an alumni of the Master of Public Health programme, shares what it meant to walk across the stage at the Royal Albert Hall.

Graduation represents the culmination of a journey and the attainment of a goal. It is an exciting period in any student’s life which brings a long journey of hard work to a close. Graduation day can be filled with an array of varying emotions, including feelings of joy, pride and contentment but also thoughts of anxiousness, worry and concern of what’s to come next.

Having been a part of the Covid cohort of 2021, I can say with confidence that I have also experienced these emotions during my time studying. Reflecting on the start of my journey, I was bursting with excitement on getting accepted to my master’s course but was also deeply concerned because of the pandemic and the future.

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Speaking authentically within higher education

How can we foster a sense of authenticity within ethnically minoritised students? Dr Zoe Moula, Teaching Fellow at the School of Public Health, aims to raise awareness of how we can promote a more inclusive educational environment and understand the barriers which can affect a student’s sense of authenticity within higher education.

The underrepresentation of ethnically minoritised students at university, and even more so in medicine, often results in identity suppression in order to ‘fit in’. Yet, this can lead to increased anxiety, and interferes with a student’s ability to succeed academically and professionally.  Societal, structural and institutional factors, such as racism, discrimination and socioeconomic inequalities may all play a part into why a student may not be able to express their true self.  It is therefore crucial that any effort to promote Equality, Diversity and Inclusion (EDI) must also protect and promote a student’s sense of authenticity. (more…)

Empowering women through the Elevat(Her) Podcast

PhD students Salina Nicoleau & Maike Haensel outline their vision for The Elevat(Her) Podcast and share the importance of highlighting positive female role models to empower other women to achieve their full potential.

Look around you – how many women are in senior positions across your university? Lucky you if you can count more than a couple. According to a recent report by the Higher Education Statistics Agency (HESA), women account for only 28% of professors in UK universities in 2020/21 (1). This is a recurring theme within many sectors, not just higher education, where there are fewer women than men in senior positions. In 2021, the number of female Fortune 500 CEOs was only 41. Yes, out of 500 CEOs, 459 were men (2).

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The trials and tribulations of applying for a PhD

Finding the right PhD programme can often be a time-consuming and lengthy exercise. Emre Yavuz, Translational Neuroscience Master’s student, shares his experience of applying for a PhD programme and the many challenges he faced along the way.

This September I’m going to be starting my PhD in Cognitive Neuroscience at UCL, supervised by Professor Hugo Spiers. Excited as I am about moving onto the next chapter of my career, choosing the right PhD for me was no easy process.

Choosing the right PhD programme comes down to many variables. When I had initially applied for several programmes in early December, I was excited by the possibility of travelling and living abroad after two years of lockdown. I had received interviews from places including Toronto, Montreal, Zurich, Lausanne and London. Although studying abroad seemed highly tempting at first, there were many other factors I had to take into account. (more…)

There is good evidence for the benefits of osteoarthritis treatment – but we should not accept the status quo

Following the publication of new draft guidance by NICE on the care and management of osteoarthritis, Dr Fiona Watt breaks down the misconceptions surrounding its impact on patients and healthcare professionals, and why developing effective treatments for the condition is more vital than ever.

8.75 million people live with osteoarthritis in the UK and the condition is the fourth leading cause of years lived with disability worldwide. Osteoarthritis commonly affects joints such as the knee, hip or hand, leading to progressive change and damage in joint tissues, frequently causing joint pain and functional difficulties. It is the leading cause of joint replacement. As an osteoarthritis researcher and someone who treats people with osteoarthritis in the NHS, I awaited the draft updated National Institute for Health & Care Excellence (NICE) guidance on the management of osteoarthritis with some anticipation. This guidance is important because it shapes (and restricts) the way that the NHS approaches advice and treatment, based on scientific evidence.

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Alzheimer’s disease: why your genes aren’t always your destiny

For Dementia Action Week, Kitty Murphy, second year PhD student at the UK DRI Centre at Imperial, shares the complex nature of Alzheimer’s disease and why there’s more to it than just our genes.

Dementia diagnosis rates are dropping for the first time ever. I wish I could tell you that this is due to less people developing dementia, and not because more people are living with it undiagnosed. According to research carried out by Alzheimer’s Society, many people are not being diagnosed due to the misconception that memory loss is a normal part of aging. However, memory loss is often an early sign of dementia, particularly in the most common cause known as Alzheimer’s disease. As a result, the Alzheimer’s Society’s Dementia Action Week, an annual awareness campaign, has made diagnosis their featured theme.

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